Code | CSB-RA022814A694phHU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
The rabbit IgG recombinant phospho-STAT5A (Y694) monoclonal antibody specifically targets the phosphorylated STAT5A at Tyr 694. The DNA encoding the phospho-STAT5A (Y694) monoclonal antibody was inserted into the plasmid and subsequently transfected into the cell line for expression. The product was purified through the affinity-chromatography method to get the pY694-STAT5A recombinant antibody. This phospho-STAT5A (Y694) antibody shows reactivity with human samples. It has been validated for ELISA, WB, and IHC applications.
STAT5, frequently activated in hematological malignancies, is a critical signaling node downstream of the BCR-ABL oncogene. STAT5 is typically activated when phosphorylated at Tyr 694 residue in the C-terminus by receptor-associated Jaks. In certain malignancies of both hematopoietic and non-hematopoietic origin, phosphorylation of STAT5 at Tyr 694 is required for cell survival, proliferation, angiogenesis, and metastasis.
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