SLC39A6 Recombinant Monoclonal Antibody

Code CSB-RA621669MA1HU
Size US$210
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  • The Binding Activity of SLC39A6 with anti-SLC39A6 antibody
    Activity: Measured by its binding ability in a functional ELISA. Immobilized Human SLC39A6(CSB-BP621669HU) at 1 μg/ml can bind Anti-SLC39A6-1 recombinant antibody, the EC50 is 0.6873-0.9010 ng/mL.
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Product Details

Uniprot No.
Target Names
Alternative Names
Estrogen regulated protein LIV 1 6 antibody; Estrogen-regulated protein LIV-1 antibody; LIV 1 antibody; LIV 1 protein, estrogen regulated antibody; S39A6_HUMAN antibody; SLC39A6 antibody; Solute carrier family 39 (metal ion transporter), member 6 antibody; solute carrier family 39 (zinc transporter), member 6 antibody; Solute carrier family 39 member 6 antibody; Zinc transporter ZIP6 antibody; ZIP 6 antibody; ZIP-6 antibody; Zrt and Irt like protein 6 antibody; Zrt- and Irt-like protein 6 antibody
Species Reactivity
Human
Immunogen
Recombinant Human SLC39A6 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Monoclonal
Isotype
hIgG1
Clone No.
13F1
Purification Method
Affinity-chromatography
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

The SLC39A6 monoclonal antibody was generated using recombinant human SLC39A6 protein as the immunogen. The SLC39A6 monoclonal antibody's DNA sequence was obtained through cDNA sequencing and cloned into a plasmid vector, which was then transfected into a host cell for expression. The resulting SLC39A6 recombinant monoclonal antibody was purified using affinity chromatography and its specificity was confirmed through ELISA. It only shows reactivity with human SLC39A6 protein. It demonstrated high affinity binding to the recombinant human SLC39A6 protein (CSB-BP621669HU) with an EC50 range of 0.6873-0.9010 ng/mL.

The SLC39A6 protein, also known as ZIP6, plays a crucial role in the cellular uptake and distribution of zinc, which is essential for various cellular processes such as DNA synthesis, immune function, and cell division. SLC39A6 is expressed in a variety of tissues, including the liver, kidney, and brain, and has been implicated in the development and progression of several diseases, including cancer and neurodegenerative disorders.

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Target Background

Function
May act as a zinc-influx transporter.
Gene References into Functions
  1. ZIP6 deficiency disturbs intracellular Zn2+ homeostasis, leading to increased cell survival in hypoxia and reduced E-cadherin expression, indicating that decreased ZIP6 expression is strongly associated with resistance to hypoxia. PMID: 28833062
  2. SLC39A6 promotes aggressiveness of esophageal carcinoma cells by increasing intracellular levels of zinc, activating phosphatidylinositol 3-kinase signaling, and up-regulating genes that regulate metastasis. PMID: 28209530
  3. Upregulation of SLC39A6 is associated with hepatocellular carcinoma. PMID: 26684241
  4. SLC39A6 may have a tumor promoting role in esophageal carcinoma PMID: 26444413
  5. Knock-down of ZIP6 but not ZIP7 in MIN6 beta cells impaired the protective effects of GLP-1 on fatty acid-induced cell apoptosis, possibly via reduced activation of the p-ERK pathway PMID: 25969539
  6. drug resistance of ovarian cancer cells to trichostatin A may be related to expression of the LIV1 gene PMID: 25420545
  7. Zinc and its transporters, ZIP6 and ZIP10, are required for the breast cancer cells motility stimulated with high glucose level, such as in diabetes. PMID: 24587242
  8. a causative role for ZIP6 in cell motility and migration PMID: 23919497
  9. Down-regulated LIV-1 cells showed significant inhibition of proliferation in vitro and reduction of tumor growth in vivo. Furthermore, E-cadherin expression increased in LIV-1 siRNA expressing Hep-G2. PMID: 23437163
  10. SLC39A6 has an important role in the prognosis of esophageal squamous-cell carcinoma and may be a potential therapeutic target. PMID: 23644492
  11. Some studies correlate LIV-1 expression with a more aggressive cancer phenotype and increased likelihood for metastasis to lymph nodes. In contrast, other evidence suggests this transporter is associated with a more favorable prognosis. [review] PMID: 22852056
  12. The results of this study showed evidence for a positive correlation between LIV1 and ZnT6 insuperior temporal, occipital, and frontal gyri in patient with alzheimer disease. PMID: 22349685
  13. LIV-1 is involved in prostate cancer progression as an intracellular target of growth factor receptor signaling which promoted EMT and cancer metastasis PMID: 22110740
  14. LIV-1 mRNA upregulation is associated with the progression of cervical cancer but not with the development of endometrial carcinoma. PMID: 17959546
  15. The present study identifies LIV1 as a critical mediator responsible for HDACi-induced apoptosis. The effect of LIV1 is, at least in part, mediated by affecting intracellular zinc homeostasis. PMID: 19887557
  16. Zip6 over-expression is not an underlying mechanism initiating breast cancer, but in fact may play a "tumor-constraining" role. PMID: 19852955
  17. Structure-function analysis of LIV-1. PMID: 12839489
  18. data suggest that LIV-1 protein is a promising candidate for a novel marker for breast cancer patients with better outcome PMID: 15986450
  19. regulation of LIV-1 protein in human breast cancer xenografts PMID: 17786585
  20. Hence, our data provide the first evidence that LIV-1 mRNA is overexpressed in cervical cancer in situ and is involved in invasion of cervical cancer cells through targeting MAPK-mediated Snail and Slug expression. PMID: 17825787
  21. LIV-1 may be a regulator of E-cadherin PMID: 18330719
  22. Single nucleotide polymorphism in SLC39A6 gene is associated with acute lymphoblastic leukemia. PMID: 19066393
  23. LIV-1 enhances the aggressive phenotype through the induction of epithelial to mesenchymal transition in human pancreatic carcinoma cells. PMID: 19724917
  24. LIV-1 co-clusters with estrogen receptor alpha in microarray analysis of breast cancer biopsies. PMID: 11911440
  25. Review of LIV-1 and other LZT proteins. PMID: 12659941
  26. LIV-1, a member of the ZIP family of zinc transporters, is an integral plasma membrane protein that transports zinc into cells. PMID: 12839489
  27. LIV-1 is coregulated with estrogen receptor in some breast cancers. PMID: 12960427

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
ZIP transporter (TC 2.A.5) family
Tissue Specificity
Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma.
Database Links

HGNC: 18607

OMIM: 608731

KEGG: hsa:25800

STRING: 9606.ENSP00000269187

UniGene: Hs.79136

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