Code | CSB-RA023072MA1HU |
Size | US$210 |
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The TROP2 monoclonal antibody was produced by immunizing with recombinant human TROP2 protein. The gene encoding the TROP2 monoclonal antibody was cloned into a plasmid vector after sequencing the cDNA. Transfection of the host cell with the plasmid vector containing the TROP2 monoclonal antibody gene was performed using a suitable transfection method. The affinity chromatography purification of the resulting TROP2 recombinant monoclonal antibody was carried out, and its specificity was tested in ELISA. This TROP2 recombinant monoclonal antibody showed the ability to bind specifically to recombinant human TROP2 (CSB-MP023072HU1d7) with an EC50 range of 0.7284-1.075 ng/mL. It can react with human TROP2 protein.
TROP2, also known as TACSTD2, is a transmembrane glycoprotein expressed in various human tissues and plays a role in cell adhesion, migration, and proliferation. It is involved in the regulation of cell growth and differentiation and has been shown to be upregulated in many types of cancer, including breast, colorectal, lung, and ovarian cancer. TROP2 overexpression is associated with tumor growth, metastasis, and poor patient prognosis. Additionally, TROP2 has been identified as a target for cancer immunotherapy.
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