TROP2

TROP2, trophoblast cell surface antigen 2, is a glycoprotein encoded by the TACSTD2 gene located on chromosome 1.TROP2 is overexpressed in a wide range of tumour cells and is involved in intracellular signalling pathways such as the MAPK/PI3K/AKT pathway, which promotes cancer cell proliferation, migration, and invasion.TROP2's regulatory roles in embryonic development and its role in tumour growth and metastasis make TROP2 a potential target for cancer therapy.