ULBP1 Recombinant Monoclonal Antibody

Code CSB-RA446786A0HU
Size US$210
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  • Western Blot
    Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, Raji whole cell lysate, HEK293 whole cell lysate
    All lanes: ULBP1 antibody at 1:1000
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 28 kDa
    Observed band size: 36-50 kDa
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Product Details

Uniprot No.
Target Names
Alternative Names
UL16-binding protein 1 (ALCAN-beta) (NKG2D ligand 1) (N2DL-1) (NKG2DL1) (Retinoic acid early transcript 1I), ULBP1, N2DL1 RAET1I
Species Reactivity
Human
Immunogen
A synthesized peptide derived from human ULBP1
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Monoclonal
Isotype
Rabbit IgG
Clone No.
13C8
Purification Method
Affinity-chromatography
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

The ULBP1 recombinant monoclonal antibody was generated using the synthesized peptide derived from human ULBP1 protein as the immunogen. To obtain the DNA sequence of the SLC39A6 monoclonal antibody, the cDNA was sequenced and the gene was cloned into a plasmid vector. The plasmid vector containing the ULBP1 monoclonal antibody gene was then transfected into a host cell using an appropriate transfection method. The resulting ULBP1 recombinant monoclonal antibody underwent affinity-chromatography purification and was tested for specificity in an ELISA and WB applications. It can react with human ULBP1 protein.

ULBP1 is a glycoprotein that functions as a ligand for the NKG2D receptor, a type of immune cell receptor that is primarily expressed on the surface of natural killer (NK) cells and a subset of T cells. ULBP1 is expressed on the surface of stressed or infected cells and plays an important role in the immune system's ability to recognize and eliminate infected or abnormal cells. When binding to NKG2D on the surface of NK cells, ULBP1 triggers a series of events that ultimately result in the activation of the NK cell and the destruction of the target cell.

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Target Background

Function
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Gene References into Functions
  1. we show that Simian Virus 40 (SV40)...evades NK cell attack through the down regulation of...ULBP1 PMID: 26992229
  2. ATF4 drives ULBP1 gene expression in cancer cell lines, while the RNA-binding protein RBM4 supports ULBP1 expression by suppressing a novel alternatively spliced isoform of ULBP1 mRNA. PMID: 26565589
  3. expression determines intrinsic acute myeloid leukemia susceptibility to allogeneic V[gamma]9V[delta]2 T cells PMID: 24911793
  4. recurrence-free survival of patients with ULBP1-negative hepatocellular carcinoma (HCC) was significantly shorter than that of patients with ULBP1-positive HCC PMID: 21756848
  5. recombinant ULBP1 fused to CD45 caused a reduction in cytotoxicity and degranulation by NK cells, implying a role for receptor ligand distribution in the activation of NK cell responses PMID: 21464092
  6. Data show that ULBP1, TFR2 and IFITM1 were associated with increased susceptibility to Vgamma9Vdelta2 T-cell cytotoxicity. PMID: 20220060
  7. These results identify Mult1 as a target for the MARCH family of E3 ligases PMID: 20870941
  8. As NKG2D ligand, ULBP1 are expressed on immature dendritic cells and plays an important role in the cytotoxic effect of NK cells against iDC. PMID: 18394338
  9. Data show that the protease NS3/4A of HCV down-regulates ULBP1 expression by inhibiting the transcription of ULBP1. PMID: 19500498
  10. ULBP1 binds to the NKG2D receptor and activates multiple signaling pathways in primary natural killer cells. PMID: 11777960
  11. The NKG2D ligand ULBP1 is up-regulated and readily detectable intracellularly in the endoplasmic reticulum of human cytomegalovirus-infected fibroblasts, where it colocalizes with viral protein UL16. PMID: 12847260
  12. ULBP1 is a human ligand of the NKG2D receptor PMID: 16901903
  13. The selective induction of ULBP1 expression by proteasome inhibitor drugs, along with variable NKG2D ligand expression by human tumor cells, indicates that NKG2D ligand genes are independently regulated. PMID: 19414815

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Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor. Endoplasmic reticulum.
Protein Families
MHC class I family
Tissue Specificity
Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.
Database Links

HGNC: 14893

OMIM: 605697

KEGG: hsa:80329

STRING: 9606.ENSP00000229708

UniGene: Hs.653255

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