UL16-binding protein-1 (ULBP1), also known as NKG2DL, is a member of the ULBPs family and one of the ligands of NKG2D. NKG2D is an activating receptor expressed on immune effector cells, which can recognize different MHC-I related molecules (such as MHCA, MHCB) and another MHC-I related molecule ULBPs. These ligands are uncommon in normal cells, and their expression is induced under conditions such as viral infection and malignant transformation of tumors. ULBP1 ligands activate NKG2D receptors on natural killer cells (NK) and CD8+ T cells, thereby triggering immune killing. The researchers found that the high expression of ULBP1 in peripheral blood exosomes of patients with preeclampsia (PE) may provide a basis for the diagnosis and treatment of PE. In addition, relevant experimental data indicate that ULBP1 is abundantly expressed in human hepatocellular carcinoma (HCC). And the expression of NKG2D receptor and ULBP1 is closely related to the existence of HCC inflammatory cells. Another study suggested that early recurrence after hepatectomy was closely related to the loss of ULBP1 expression. Therefore, ULBP1 is expected to be a molecular target for HCC immunotherapy.
● Recombinant Human UL16-binding protein 1(ULBP1) (Active) (CSB-MP887177HU)
Validated Data
Greater than 90% as determined by SDS-PAGE.
Immobilized KLRK1 (CSB-MP012474HU1) at 10 μg/ml can bind human ULBP1, the EC50 of human ULBP1 protein is 228.5-427.6 ng/ml.
Human KLRK1 protein captured on COOH chip can bind Human ULBP1 protein with an affinity constant of 2.27 nM as detected by LSPR Assay.
● Recombinant Human UL16-binding protein 1(ULBP1),Biotinylated (Active) (CSB-MP887177HUj1-B)
Validated Data
Greater than 95% as determined by SDS-PAGE.
Immobilized KLRK1 (CSB-MP012474HU1) at 10 μg/ml can bind human Biotinylated ULBP1, the EC50 is 4.254-7.295 ng/ml.
The following ULBP1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
ULBP1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA025609GA01HU | ULBP1 Antibody |
Human | ELISA,WB,IHC |
CSB-PA887177LA01HU | ULBP1 Antibody |
Human | ELISA, IHC, IF |
CSB-PA887177LB01HU | ULBP1 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA887177LC01HU | ULBP1 Antibody, FITC conjugated |
Human | |
CSB-PA887177LD01HU | ULBP1 Antibody, Biotin conjugated |
Human | ELISA |
ULBP1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP887177HU CSB-EP887177HU CSB-BP887177HU CSB-EP887177HU-B |
Recombinant Human NKG2D ligand 1(ULBP1) |
Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-MP887177HU | Recombinant Human UL16-binding protein 1(ULBP1) (Active) |
Mammalian cell |
CSB-MP887177HUj1-B | Recombinant Human UL16-binding protein 1(ULBP1),Biotinylated (Active) |
Mammalian cell |