ULBP1, also known as UL16 binding protein 1, is a protein coding gene that encodes a ligand for the NKG2D receptor on NK cells and T-cells. It plays a crucial role in the immune system by activating multiple signaling pathways, including JAK2, STAT5, ERK, and PI3K kinase/Akt. ULBP1 is highly expressed in various hematologic and solid tumors, making it a potential target for cancer immunotherapy. The protein's interaction with NKG2D leads to the activation of NK cells and T-cells, which can target and eliminate abnormal or infected cells.
In terms of drug development, there are ongoing clinical trials for drugs targeting ULBP1, such as the CAR-T therapy CYAD-01, which has shown promising results in treating hematologic malignancies. Additionally, an anti-ULBP1 monoclonal antibody is in the drug discovery phase, offering new opportunities for the treatment of multiple hematological and solid tumors.
Recombinant Human UL16-binding protein 1 (ULBP1) (Active) (CSB-MP887177HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized KLRK1 (CSB-MP012474HU1) at 10 μg/ml can bind human ULBP1, the EC50 of human ULBP1 protein is 228.5-427.6 ng/ml.
Human KLRK1 protein Fc tag (CSB-MP012474HU1) captured on COOH chip can bind Human ULBP1 protein Fc/myc tag (CSB-MP887177HU) with an affinity constant of 2.27 nM as detected by LSPR Assay.
ULBP1 Recombinant Monoclonal Antibody (CSB-RA446786A0HU)
Validated Data
Western Blot
Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, Raji whole cell lysate, HEK293 whole cell lysate
All lanes: ULBP1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 28 kDa
Observed band size: 36-50 kDa
The following ULBP1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
ULBP1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA025609GA01HU | ULBP1 Antibody | Human | ELISA,WB,IHC |
CSB-PA887177LA01HU | ULBP1 Antibody | Human | ELISA, IHC, IF |
CSB-PA887177LB01HU | ULBP1 Antibody, HRP conjugated | Human | ELISA |
CSB-PA887177LC01HU | ULBP1 Antibody, FITC conjugated | Human | |
CSB-PA887177LD01HU | ULBP1 Antibody, Biotin conjugated | Human | ELISA |
CSB-RA446786A0HU | ULBP1 Recombinant Monoclonal Antibody | Human | ELISA, WB |
ULBP1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP887177HU CSB-EP887177HU CSB-BP887177HU CSB-EP887177HU-B |
Recombinant Human NKG2D ligand 1 (ULBP1) | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-MP887177HU | Recombinant Human UL16-binding protein 1 (ULBP1) (Active) | Mammalian cell |
CSB-MP887177HUj1-B | Recombinant Human UL16-binding protein 1 (ULBP1),Biotinylated (Active) | Mammalian cell |