Recombinant Mouse C-C chemokine receptor type 7 (Ccr7)

Code CSB-CF004846MO
MSDS
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Source in vitro E.coli expression system
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Product Details

Target Names
Uniprot No.
Alternative Names
Ccr7; Cmkbr7; Ebi1; Ebi1h; C-C chemokine receptor type 7; C-C CKR-7; CC-CKR-7; CCR-7; Epstein-Barr virus-induced G-protein coupled receptor 1; EBI1; EBV-induced G-protein coupled receptor 1; MIP-3 beta receptor; CD antigen CD197
Species
Mus musculus (Mouse)
Expression Region
25-378
Target Protein Sequence
QDEVTDDYIGENTTVDYTLYESVCFKKDVRNFKAWFLPLMYSVICFVGLLGNGLVILTYI YFKRLKTMTDTYLLNLAVADILFLLILPFWAYSEAKSWIFGVYLCKGIFGIYKLSFFSGM LLLLCISIDRYVAIVQAVSAHRHRARVLLISKLSCVGIWMLALFLSIPELLYSGLQKNSG EDTLRCSLVSAQVEALITIQVAQMVFGFLVPMLAMSFCYLIIIRTLLQARNFERNKAIKV IIAVVVVFIVFQLPYNGVVLAQTVANFNITNSSCETSKQLNIAYDVTYSLASVRCCVNPF LYAFIGVKFRSDLFKLFKDLGCLSQERLRHWSSCRHVRNASVSMEAETTTTFSP
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Receptor for the MIP-3-beta chemokine.
Gene References into Functions
  1. Data report that CCR7 mediates CD11c+ cell migration from the CNS parenchyma to the meningeal lymphoid vessels and eventually to the deep cervical lymph nodes during neuroinflammation. In the absence of CCR7, dendritic cells are retained in the CNS and exacerbate neuroinflammation. PMID: 28216674
  2. Conditions for optimal dendritic cells guidance are perfectly provided by the CCL21 gradients measured in vivo. Furthermore, CCR7 signal termination by the G-protein-coupled receptor kinase 6 (GRK6) is crucial for haptotactic but dispensable for chemotactic CCL21 gradient sensing in vitro and confirm those observations in vivo. PMID: 28457871
  3. CCR7 deficiency results in apoptosis of Sirpa- dendritic cells, which is counterbalanced by expansion of immature Sirpa+ dendritic cells that efficiently induce Treg generation. PMID: 28978470
  4. These data show that CCR7-CCL19/CCL21 axis facilitates retention CD4(+) T lymphocytes at the site of collateral artery remodeling, which is essential for effective arteriogenesis. PMID: 28275068
  5. Results demonstrated that the deletion of CCR7 significantly decreases levels of activated Notch1, and provide evidence that crosstalk between CCR7 and Notch1 promotes stemness in mammary cancer cells ultimately potentiating mammary tumor progression. PMID: 28137279
  6. CCR7 deficiency lead to accumulation of CD8+ adipose tissue leukocytes, which was further exacerbated by HFD feeding. PMID: 27655794
  7. in the current study, we used interval mapping to validate a locus on Chr 15, named Ity8, linked to Salmonella resistance in AcB60 mice. Global gene expression analysis during infection identified AcB60-specific expression of genes involved in Ccr7 signaling, including downstream effector Mapk11 (mitogen-activated protein kinase 11), located within the Ity8 interval, and representing a potential positional candidate gene PMID: 27913859
  8. Taken together, these data suggest that CCR7 biases memory CD8 T cells toward IL-7-dependent niches over IL-15-dependent niches, which provides insight into the homeostatic regulation of different memory T-cell subsets. PMID: 27385825
  9. Prominent mucosal immune responses in CCR7-deficient mice increased the efficiency of bacteria clearance from the FRT(female reproductive tract) while reducing tissue-associated inflammation and pathology; increased numbers of lymphocytes within the FRT result in pathogen clearance with reduced immune-mediated pathology PMID: 28801359
  10. CCR7 is required to mount a robust immune response against enteropathogenic Y. pseudotuberculosis by promoting Th17-like responses in mesenteric lymph nodes. PMID: 28329174
  11. CCR7 overexpression and RelB knockdown (KD) in imDCs improve skin-graft survival in a murine skin-transplantation model. Transfection with Ad-CCR7 and RelB KD in imDCs may be an effective approach inducing immune tolerance, thus being potentially valuable for inhibiting allograft rejection. PMID: 28578354
  12. data point to Ccr7 as a critical host defense restriction factor limiting neuroinflammation during acute West Nile virus infection PMID: 28356527
  13. The results suggest that CCR7 plays a causal role in maintaining innate and adaptive immunity in obesity. PMID: 27207557
  14. these data indicate that CCR7 and BTLA cooverexpression imparts an intermediate immune phenotype in mmature dendritic cells when compared to that in CCR7- or BTLA-expressing counterparts that show a more immunocompetent or immunotolerant phenotype PMID: 28393074
  15. Results suggest that baicalin exerts an inhibitory effect on airway inflammation, and this effect may be associated with the inhibition of CCR7 and its ligands, CCL19 and CCL21, as well as on the nuclear factor-Kappa B (NF-kappaB) pathway in a mouse model of asthma. PMID: 27666000
  16. This study reveals a role for CCR7 in limiting Treg recirculation back to the thymus and enables separation of the mechanisms controlling Treg production and thymic recirculation. PMID: 26832402
  17. expression on antiviral T cells is mandatory to prevent lethal neuroinflammatory disease PMID: 26921107
  18. data reveal that CCR7 plays multifaceted roles in regulating collecting vessel permeability and fibrosis, with one of the key players being IRF4-dependent DCs. PMID: 26999610
  19. the graft site microenvironment plays a critical role in alloimmunity by determining DC trafficking through the CCR7-CCL19/21 axis. PMID: 27031839
  20. reduced expression in mononuclear inflammatory cells isolated from the brain during active stage of experimental autoimmune encephalomyelitis PMID: 25957582
  21. The results highlight a novel role of CCR7 in regulating effector CD8 T cell migration in the spleen and demonstrate differential requirement of CCR7 for primary and secondary CD8 T cell responses to infection. PMID: 26500349
  22. mucosal draining lymph nodes express CCR7, which has a role in trafficking of RORgamma innate lymphoid cells PMID: 25575242
  23. results demonstrate a contribution of CCR7 to STAP-2-dependent enhancement of BCR-ABL-mediated cell growth in Ba/F3 cells PMID: 26102025
  24. CCR7 increases the secretion of nitric oxide and modulates the T cell immune response. PMID: 25549354
  25. Results suggest that Mfn2 and OPA1 are upregulated during bone marrow progenitor differentiation and promote the migration of immature dendritic cells by regulating the expression of CCR7. PMID: 25387754
  26. CCR7 regulates the intestinal TH1/TH17/Treg balance during Crohn's-like murine ileitis. PMID: 25637591
  27. Rescue with both CCR7 and ICAM-1 reverses impaired DC homing to lymph nodes in vivo when FOXO1 is deleted. PMID: 25786691
  28. Ccr7 is gradually silenced during the differentiation of monocytes to monocyte-derived dendritic cells. PMID: 25297875
  29. CCR7 is required for a protective immune response to intracellular L. major infection. PMID: 24205367
  30. CCR7 guides migration of mesenchymal stromal cells to secondary lymphoid organs and thus highly intensify their in vivo immunomodulatory effects. PMID: 24496849
  31. The involvement of DCs and their expression of CCR7 in corneal and ocular surface diseases such as in ocular allergy, dry eye disease, immune rejection and more, are also reviewed here. PMID: 24725321
  32. CCR7 directs the recruitment of T cells into inflamed pancreatic islets of nonobese diabetic (NOD) mice PMID: 24687731
  33. Results suggest reduced interest in social novelty in response to maternal separation in CCR7-/-, but not wild-type mice PMID: 24503116
  34. The results of this study suggest that ccr7 may play a role in cognition and learning behaviour, as well as anxiety and other behaviours. PMID: 24333375
  35. Novel roles for CCR7 are identified during intrathymic T cell development, highlighting its importance in enabling multiple alphabetaT cell lineages to access the adult thymic medulla. PMID: 24990081
  36. Immunohistology revealed that CCR7 and CCR9 expression was important for gammadelta T-cell localization within thymic medulla or cortex, respectively PMID: 24500801
  37. results indicate that CCR7 must be expressed on dendritic cells, as well as peripheral cells, to allow an efficient immune response to Leishmania major PMID: 24410820
  38. Post-thrombotic vein wall remodeling is impaired in CCR7(-/-) mice, with a profibrotic phenotype, is dependent on the thrombotic mechanism, and is mediated by circulating CCR7(+) cells. PMID: 24311382
  39. CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets. PMID: 24378538
  40. TSLP activated a subset of CD11b(+) DCs in the skin to produce CCL17, upregulate CCR7, and migrate to the draining lymph node to initiate Th2 differentiation. PMID: 24123684
  41. Chromatin immunoprecipitation sequencing revealed the transcription factor Tcf7 and the chemokine receptor Ccr7 as Foxo1-bound target genes, which have critical functions in central-memory T cell differentiation and trafficking. PMID: 23932570
  42. our findings do not support the notion that CCR7 plays a discernable role in the trafficking of Ag-experienced CD4 T cells to the lymph nodes PMID: 23935190
  43. Genetic deletion of Ccr7 exacerbates atherosclerosis by increasing T cell accumulation in atherosclerotic lesions. PMID: 23180724
  44. Data indicate that naive lung CD4 cells supply the draining lymph nodes through a CD62L-independent, CCR7-dependent pathway. PMID: 23319636
  45. Exposure to CCR7 in a model of contact hypersensitivity following sublethal total body irradiation results in diminished immunosurveillance in the skin, a mechanism which could render the host more susceptible to pathogens. PMID: 23002435
  46. these data imply a causal link between CCR7 expression, IL-1beta level, and Na malabsorption owing to altered ENaC expression and diarrhea. PMID: 22395421
  47. Phosphatidylinositol 3-kinase and NF-kappa B signaling pathways play a critical role in CCR7-mediated IL-23 production by murine dendritic cells. PMID: 22591694
  48. Plasmacytoid dendritic cells (pDCs) trafficking to the splenic white pulp require CCR7 signaling. PMID: 22634622
  49. CCR7 expression contributes to the immunopathogenesis of allergic conjuctivitis, thereby allowing significant inhibition of this experimental condition via topical CCR7 antibody blockade. PMID: 22507838
  50. Cell sorting highlighted the involvement of CD11c(+) cells in the CCR7-independent transport. PMID: 22622847

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family
Database Links
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