Recombinant Human Tumor necrosis factor ligand superfamily member 13B protein(TNFSF13B) (Active)

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Code CSB-AP002191HU
Product Type Tumor Necrosis Factor
Size US$112Purchase it in Cusabio online store
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Uniprot No. Q9Y275
Lead Time 5-10 business days
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Storage Buffer 0.2 μm filtered PBS, pH7.4, with 0.02 % Tween-20 ,lyophilized
Alias B lymphocyte stimulator, B-cell-activating factor, BAFF, Dendritic cell-derived TNF-like molecule, TNF- and APOL-related leukocyte expressed ligand 1
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a mouse splenocyte survival assay is 0.5-2 ug/ml.
Purity >95% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence M+AVQGPEETV TQDCLQLIAD SETPTIQKGS YTFVPWLLSF KRGSALEEKE NKILVKETGY FFIYGQVLYT DKTYAMGHLI QRKKVHVFGD ELSLVTLFRC IQNMPETLPN NSCYSAGIAK LEEGDELQLA IPRENAQISL DGDVTFFGAL KLL
Research Area Cancer
Source E.coli
Gene Names TNFSF13B
Expression Region 234-285aa
Tag Info Tag-Free
Mol. Weight 17.2 kDa
Protein Description Partial
PubMed ID 10331498; 10359578; 10398604; 12867412; 22749832; 12975309; 15057823; 15489334; 10973284; 11853672; 11827482; 11862220
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Function Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
Subcellular Location Cell membrane, Single-pass type II membrane protein, SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily member 13b, soluble form: Secreted
Protein Families Tumor necrosis factor family
Tissue Specificity Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver,
Database Links

HGNC: 11929

OMIM: 603969

KEGG: hsa:10673

STRING: 9606.ENSP00000365048

UniGene: Hs.525157

Pathway NF-kappa B signaling pathway

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