Recombinant Human Tumor necrosis factor receptor superfamily member 10B(TNFRSF10B),partial

In Stock
Code CSB-AP004921HU
Product Type Tumor Necrosis Factor
Size US$65Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. O14763
Lead Time 5-10 business days
Storage Buffer Lyophilized from a 0.2 μm filtered 20 mM PB, 150 mM NaCl, pH 7.4
Alias Tumor Necrosis Factor Receptor Superfamily Member 10B; Death Receptor 5; TNF-Related Apoptosis-Inducing Ligand Receptor 2; TRAIL Receptor 2; TRAIL-R2; CD262; TNFRSF10B; DR5; KILLER; TRAILR2; TRICK2; ZTNFR9
Species Homo sapiens (Human)
Biological_Activity The ED50 as determined by its ability to inhibit TRAIL-mediated cytotoxicity using L?929 mouse fibroblast cells treated with TRAIL is typically 23 ng/mL.
Purity Greater than 95% as determined by SDS-PAGE.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Research Area Cancer
Source Mammalian cell
Gene Names TNFRSF10B
Expression Region 56-182aa
Tag Info C-terminal 6xHis-FC-tagged
Mol. Weight 42.2 kDa
Protein Description Partial
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Function Receptor for the cytotoxic ligand TNFSF10/TRAIL
Involvement in disease Squamous cell carcinoma of the head and neck (HNSCC)
Subcellular Location Membrane, Single-pass type I membrane protein
Tissue Specificity Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus,
Database Links

HGNC: 11905

OMIM: 275355

KEGG: hsa:8795

STRING: 9606.ENSP00000276431

UniGene: Hs.521456

Pathway p53 signaling pathway
Natural killer cell mediated cytotoxicity

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