TNFRSF10B Antibody, HRP conjugated

Datasheet
Code CSB-PA08165B0Rb
Size US$299
Uniprot No. O14763
Protocols ELISA Protocol
Immunogen Recombinant Human Tumor necrosis factor receptor superfamily member 10B protein (56-210AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262), TNFRSF10B, DR5 KILLER TRAILR2 TRICK2 ZTNFR9
Immunogen Species Human
Research Area Cell Biology
Target Names TNFRSF10B
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Receptor for the cytotoxic ligand TNFSF10/TRAIL
Involvement in disease Squamous cell carcinoma of the head and neck (HNSCC)
Subcellular Location Membrane, Single-pass type I membrane protein
Tissue Specificity Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus,
Database Links

HGNC: 11905

OMIM: 275355

KEGG: hsa:8795

STRING: 9606.ENSP00000276431

UniGene: Hs.521456

Pathway p53 signaling pathway
Apoptosis
Necroptosis
Natural killer cell mediated cytotoxicity

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