Recombinant Human Tumor necrosis factor receptor superfamily member 10B protein(TNFRSF10B) (Active)

In Stock
Code CSB-AP002291HU
Product Type Tumor Necrosis Factor
Size US$112Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. O14763
Lead Time 5-10 business days
Image
Storage Buffer 0.2um filtered PBS, pH 7.4 ,lyophilized
Alias Death receptor 5, TRAIL receptor 2, TRAIL-R2, CD antigen CD262
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. rHusTRAIL-R2 reduced the production of LPS- induced TNF by its ability to neutralize endogenous TRAIL in fresh human PBMC. In this assay, endogenous TRAIL is induced during a 24 hour exposure to LPS (10 ng/mL) but in the presence of rHusTRAIL-R2, TRAIL-induced TNF is suppressed.
Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence ESALITQQDL APQQRAAPQQ KRSSPSEGLC PPGHHISEDG RDCISCKYGQ DYSTHWNDLL FCLRCTRCDS GEVELSPCTT TRNTVCQCEE GTFREEDSPE MCRKCRTGCP RGMVKVGDCT PWSDIECVHK ES
Research Area Cancer
Source E.coli
Gene Names TNFRSF10B
Expression Region 52-183aa
Tag Info Tag-Free
Mol. Weight 14.8 kDa
Protein Description Partial
PubMed ID 9285725; 9311998; 9373179; 9430227; 9325248; 9326928; 9242610; 9242611; 10072170; 12975309; 17974005; 16421571; 15489334; 14759258; 15322075; 23498957; 10549288; 10542098; 23555243
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Function Receptor for the cytotoxic ligand TNFSF10/TRAIL
Involvement in disease Squamous cell carcinoma of the head and neck (HNSCC)
Subcellular Location Membrane, Single-pass type I membrane protein
Tissue Specificity Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus,
Database Links

HGNC: 11905

OMIM: 275355

KEGG: hsa:8795

STRING: 9606.ENSP00000276431

UniGene: Hs.521456

Pathway p53 signaling pathway
Apoptosis
Necroptosis
Natural killer cell mediated cytotoxicity

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