Does Antibody-dependent Enhancement Occur in SARS-CoV-2 Infection?In 1964, Hawkes et al. demonstrated enhanced infectivity of viruses, including arboviruses, Murray Valley encephalitis virus, West Nile virus (WNV), Japanese encephalitis virus (JEV), and Getah viruses in the presence of...
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The Overview of Cell ViabilityCell-based assays are generic tools for measuring numerous biochemical or cellular functions. Bioassays can study various events including cell proliferation, morphology, migration, apoptosis, genetics, and signal tran...
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Histones and Their Roles in DiseasesMost cells in the human body (except germ cells) are diploid and contain approximately 6 billion base pairs of DNA. Each base pair is about 0.34 nanometers long, so the total length of human diploid DNA is around 2 m. Ho...
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Claudin 18.2, is a 'Dark Horse' in Anti-tumour Therapy?In May, 2020, the world's first CAR-T therapy targeting Claudin 18.2 was approved in the US; in June, 2020, the world's first Claudin 18.2/PD-L1 bispecific antibody preclinical data was presented at the AACR; and on July...
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GPC3: The Next-Promising Target in Cancer ImmunotherapyRecently, 2021 American Society of Clinical Oncology (ASCO) Annual Meeting announced the abstract of a fourth generation of GPC3 CAR-T (4G-CAR-GPC3 T) cells therapy. The abstract suggested that 4G-CAR-GPC3 T cells treatm...
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Neuronal Markers and Neurodegenerative DiseasesNeurons are highly specialized nerve cells that receive and transmit electrical or chemical signals to coordinate all of the necessary functions for life. Neurons are typically composed of a cell body, dendrites, an ax...
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Oncogenes and CancerIn fact, everyone has genes that possess the ability to cause cancer. These genes are known as proto-oncogenes, which are expressed to control normal cell processes such as proliferation, differentiation, and apoptosis. ...
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Protein Acetylation: An Important Post-translational Modification in Eukaryotic CellsAs is well-known, post-translational modifications (PTMs) are essential mechanisms for eukaryotic cells to diversify protein functions and dynamically coordinate signaling networks. Vincent Allfrey and colleagues first...
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A Group of Promising Proteins - Cell Cycle MarkersMost eukaryotic cells depends on an internal clock for survival; they proceed through a sequential event known as the cell cycle . The cell cycle allows multicellular organisms to grow and divide and single-celled orga...
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The Oncogene HER2: a New Target for Drug-Resistant TumorsOn March 17, 2021, a research paper entitled "Targeting transcription of MCL-1 sensitizes HER2-amplified breast cancers to HER2 inhibitors" [1] has attracted attention. Researchers found that the combination of MCL-1 inh...
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