What Are the Best Antibody Purification Methods for Your Research Needs?Antibodies are indispensable tools in biological research, medicine, and various industrial applications. Highly pure antibodies give rise to reliable experimental outcomes and rigorous clinical data, ensuring safety and...
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CT83/KK-LC-1: a Promising Therapeutic Target of CTAs Family, Currently in Clinical Research for Breast, Lung, Gastric Cancers, and Beyond!Cancer Testis Antigens (CTAs) are proteins primarily expressed in testicular tissue but not in other normal tissues. However, CTAs show heightened expression in various tumors, with many having tumorigenic properties. Am...
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IL-6: an Important Participant in the Inflammatory Cascade, One of the Most Functional Cytokines in Various Diseases Research!On February 22, 2024, Cell Reports published a significant article titled "Insights into IL-6 Signaling Inhibition with Therapeutic Antibodies." This study highlights how antibodies like Tocilizumab and Sarilumab block t...
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Exploring Protein-Protein Interactions: A Comprehensive Guide to Understanding and Utilizing ItProteins, the executor of life activities, efficiently execute cellular functions through interactions, frequently in the form of protein-protein interactions. Understanding any cellular process requires knowing which pr...
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Interleukin 4 receptor (IL-4R/IL-4Ra): a Multifunctional Target of Cytokines, Suggesting Diverse Potential in Asthma, Rhinitis, Viral, and Tumor Research!On January 26, 2024, a pharmaceutical company license two promising products: an anti-TSLP monoclonal antibody and an anti-IL-4Ra monoclonal antibody. These aim to treat respiratory disorders like asthma and chronic obst...
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In Vivo vs. In Vitro: Choosing the Right Experimental Model for Your ResearchResearchers conduct experiments using various experimental models, which can be categorized into two main types: in vivo and in vitro based on where the research is conducted and the type of biological system being studi...
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Dipeptidase 3 (DPEP3): an Emerging Member of the DPEP Family, a Potential Therapeutic Target in Male Fertility or Tumor Research!On March 15, 2024, the Journal of Affective Disorders published a study delving into the molecular mechanisms of post-traumatic stress disorder (PTSD) and major depression (MDD). The research revealed a notable decrease ...
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CEACAM8: a Member of CEA Family, Emerging as a Vital Player in Gynaecological or Gastrointestinal Cancer Research!In February 2024, the Elsevier database published a article based on bioinformatics analysis. This study identified 42 differentially expressed genes through transcriptomic analysis of multiple sclerosis patients during ...
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CD70 (CD27L/TNFSF7): a TNF Receptor Member, a “Star” Target for Clinical Research in Systemic Lupus Erythematosus (SLE), Arthritis, and Tumors!On January 27, 2024, a study published in the Journal of Autoimmunity explored the impact of CD70 methylation on systemic lupus erythematosus (SLE), revealing elevated levels in SLE patients' CD4+ T cells, potentially li...
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Serotransferrin/TF: a Major Transferrin in Plasma, a Novel TF-Modified Nanoparticle for Tumor-Targeting Research!In January 2024, a research paper titled "Remyelinating effect driven by transferrin-loaded extracellular vesicles" was included in the Scholar database [1]. The study explored using extracellular vesicles (EVs) as carri...
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