TNFRSF13C (BAFF-R): A Key Target for Immune Regulation and Disease TreatmentTNFRSF13C (BAFF-R), a member of the TNF receptor superfamily, is pivotal for immune regulation. This review delves into its background, mechanisms, signaling pathways, associated diseases, and drug development progress. ...
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How to Choose the Right Recombinant Protein for Your Experimental Model?Recombinant proteins play a critical role in modern biological research, with increasingly extensive applications ranging from basic studies and disease modeling to drug research and development. The ability to produce a...
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IL-6: A Central Factor in Cytokine Storms and a Health Alert for Infections and DiseasesInterleukin-6 (IL-6) is a cytokine with diverse biological activities, involved in immune regulation and inflammatory responses [1]. Research into IL-6's properties and its role in diseases is crucial for developing new ...
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How AI is Reshaping Biological Research? A Comprehensive Guide to Tools and Practical StrategiesThe rapid evolution of artificial intelligence (AI) technologies, particularly large language models (LLMs) like ChatGPT [1,2], Claude, Gemini [3], and Deepseek, has profoundly influenced all facets of life, including bi...
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TNFSF18: Unlocking New Frontiers in Cancer ImmunotherapyCAR-T cell therapy has shown remarkable efficacy in treating hematologic malignancies but faces challenges in solid tumors due to the immunosuppressive tumor microenvironment, which limits CAR-T cell proliferation, persi...
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CSF2/GM-CSF: A Key Molecule in Immune Regulation and Disease TreatmentIn recent years, CSF2 (Granulocyte-Macrophage Colony-Stimulating Factor, GM-CSF) has garnered significant attention in biomedical research. CSF2 plays a crucial role in immune regulation, inflammatory responses, and tumo...
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The Structure, Function, and Research Progress of Lymphotoxin β Receptor (LTBR) in Disease and Drug DevelopmentLymphotoxin β Receptor (LTBR), also known as Tumor Necrosis Factor Receptor Superfamily Member 3 (TNFRSF3), plays a crucial role in the immune system and is vital for maintaining immune balance and overall health. As re...
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CD79A and CD79B: Key Targets in B Cell Signaling Pathways and Therapeutic PotentialAs crucial components of the B-cell receptor (BCR), CD79A and CD79B play a pivotal role in B-cell signal transduction and have garnered extensive attention in the field of blood cancer treatment. In recent years, signifi...
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TNFSF15/TL1A: The Rise of the Next Billion-Dollar Target as Pharma Giants Stake Their ClaimsRecently, there has been a flurry of good news regarding TNFSF15/TL1A. Sansheng Guojian Pharmaceutical（Group）Co., Ltd.'s anti-TL1A monoclonal antibody SSGJ-627 injection has had its IND application accepted by the CD...
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How to Choose An Appropriate Isotype Control Antibody?Selecting the appropriate isotype control antibodies is a critical decision in experimental design, yet it often gets considerably less focus than other research components. For many researchers, isotype control is merel...
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