SIGIRR: A Novel Member of the TIR Superfamily Acts as the Anti-Inflammatory 'Brake' to Control Immune Response in Various Diseases!Lately, the journal Seminars in Immunology published an intriguing article titled "IL-1R8: A Molecular Brake for Anti-Tumor and Anti-Viral Activity of NK Cells and ILCs" [1]. The study highlights the significance of IL-1...
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The Power and Promise of Stable Cell LinesThe HeLa cell line, the first immortalized human cell line, was established in 1951 [1]. In 1975, hybridoma technology enabled the generation of stable hybridoma cell lines producing monoclonal antibodies [2]. Recombinan...
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TFR1 (TFRC): a Stimulator of Fe Transport Affects Anemia, Neurodegenerative Disorders and Cancers!The transferrin receptor 1 (TFR1) controls systemic iron homeostasis, which mediates cellular iron uptake through endocytosis of iron-loaded transferrin (Tf). Iron is an indispensable element required for cell growth and...
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GIPR: the Crucial Regulator of Glucose and Lipid Metabolism in Diabetes and Obesity!GIPR has garnered significant attention lately. According to Pharmsnap clinical database, a GIPR target drug (Tirzepatide) has already entered the market in China for treating type 2 diabetes, obesity, and cardiovascular...
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Microglial Markers: Insights into Microglial Activation and FunctionGerman physician and psychiatrist Pío del Río-Hortega first discovered microglia in 1919. Initially thought to be static and supportive cells in the central nervous system (CNS), subsequent research revealed their dyna...
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What Do You Need to Know Before Researching Human Metapneumovirus?Human metapneumovirus (hMPV) is a respiratory virus that was first identified in 2001. It belongs to the Paramyxoviridae family and the Pneumovirus genus, which also includes respiratory syncytial virus (RSV). Human meta...
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Protein Phosphorylation: The Dynamic Language of Cellular RegulationProtein phosphorylation, the reversible addition of a phosphate group to specific amino acid residues in proteins, is a fundamental post-translational modification (PTM) that regulates numerous cellular processes. This e...
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CADM1: an Immunoglobulin Superfamily Molecule, a New Tumor Suppressor Gene!CADM1 is a cell adhesion molecule that belongs to the immunoglobulin superfamily, and it has a ubiquitous presence in the human body. Apart from its abundance in multiple normal tissues where it serves various functions,...
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CD69: a Classical Early Marker of Lymphocyte Activation, a Pivotal Regulator of Hematologic Diseases and Autoimmune Disorders!A research paper entitled “HSF1 promotes CD69+Treg differentiation to inhibit colitis progression” was recently published in the journal Theranostics [1]. The study found that knockdown of CD69 induced autoimmune dis...
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DSG2: a Vital Member of Desmosomal Cadherin Family, an Exciting New Target for Cardiomyopathy, Adenovirus, and Tumors!DSG2 stands for desmoglein-2, which is a type of desmosomal cadherin protein. It is a well-established fact that mutations in a variety of desmogleins can lead to the development of cardiomyopathy, like Desmocollin-2, De...
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