Protein Tyrosine Kinases: Anti-tumor Targets to be Explored Urgently
Protein Tyrosine Kinases: Anti-tumor Targets to be Explored UrgentlyIn 2001, the first kinase inhibitor imatinib was approved by the FDA and successfully marketed, representing an important breakthrough of kinase drugs in the field of molecular targeted cancer treatment. Recently, an art...
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Tuberculosis--A Resurgent
Tuberculosis--A Resurgent When it comes to tuberculosis, the first thing that comes to mind may be "Sister Lin" in the "A Dream in Red Mansions", or perhaps it is Lin Huiyin, the goddess of the Republic of China who is both talented and beautiful...
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SLC7A11: a New Potential Therapeutic Target via Induced Ferroptosis in Tumors!
SLC7A11: a New Potential Therapeutic Target via Induced Ferroptosis in Tumors!Lately, Cell (Impact Factor=66.850) released "Ferroptosis" review to mark the ten-year anniversary of the discovery of ferroptosis [1]! The article focuses on the key regulators of this form of cell death, which promise ...
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A Review of WFDC8 Antibody
A Review of WFDC8 AntibodyProduct Name: WFDC8 antibody Code:  CSB-PA818226LA01HU I am Dr. Ferran Barrachina, currently a postdoctoral fellow at the Massachusetts General Hospital and Harvard Medical School in Boston (United States). My r...
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A Review of A Human NGAL ELISA Kit
A Review of A Human NGAL ELISA KitProduct Name: Human neutrophil gelatinase-associated lipocalin, NGAL ELISA Kit Code: CSB-E09408h We used the Elisa kit CSB-E09408h for the assessment of NGAL concentration in urine samples of children, adults and chr...
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CLDN4: A Potential Prognostic Indicator and Therapeutic Target in Tumors!
CLDN4: A Potential Prognostic Indicator and Therapeutic Target in Tumors!Presently, a paper entitled "TGF-β induces GBM mesenchymal transition through upregulation of CLDN4 and nuclear translocation to activate TNF-α/NF-κB signal pathway" was published on Cell Death & Disease. The stud...
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Intestinal Mucosal Barrier Bodyguard --ALPi
Intestinal Mucosal Barrier Bodyguard --ALPiAlkaline phosphatase: Alkaline phosphatase (AKP/ALP/AP) is a monobasic phosphohydrolase that widely distributes in human liver, bone, intestine, kidney, placenta and other tissues, and is excreted out of the gallbladd...
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ZG16B: A New Tumor Biomarker Offers Important Insights for Drug Development in Pancreatic Cancer!
ZG16B: A New Tumor Biomarker Offers Important Insights for Drug Development in Pancreatic Cancer!ZG16B has recently emerged as a novel oncogene based on comprehensive bioinformatics analysis. Apparently, treatment of malignancies has experienced immense progress through immunotherapy. But the success of immunotherap...
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Proteolysis Targeting Chimera (PROTAC): A
Proteolysis Targeting Chimera (PROTAC): A Today, progress is widely being made in targeted cancer therapy. Most current drug targets are G-protein coupled receptors, nuclear receptors, ion channels or enzymes. Nevertheless, up to 80% of proteins remain “undrug...
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How to Validate An Antibody?
How to Validate An Antibody?With the progress of science and medicine, antibodies have become potent tools to recognize, detect, isolate, or visualize their corresponding antigens in basic science research and clinical assays. Whether or not antibo...
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