TNFSF15/TL1A: The Rise of the Next Billion-Dollar Target as Pharma Giants Stake Their ClaimsRecently, there has been a flurry of good news regarding TNFSF15/TL1A. Sansheng Guojian Pharmaceutical（Group）Co., Ltd.'s anti-TL1A monoclonal antibody SSGJ-627 injection has had its IND application accepted by the CD...
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How to Choose An Appropriate Isotype Control Antibody?Selecting the appropriate isotype control antibodies is a critical decision in experimental design, yet it often gets considerably less focus than other research components. For many researchers, isotype control is merel...
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Antigen Retrieval: Uncovering Antigen Masking to Improve Immunohistochemistry ResultsHave you ever handled fixed tissues? If you prepare tissue sections for immunohistochemistry (IHC), you probably have! In IHC experiments, tissue samples are often treated with chemical fix...
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Advancements in CDH6-Targeted Drug Research for Cancer TreatmentRecent advancements in CDH6-targeted drug research include First Three's initiation of the international multicenter Phase II/III clinical trial for its CDH6-targeted antibody-drug conjugate (ADC), R-DXd, marking it as t...
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TIGIT Targeted Immunotherapies Offer New Hope for Cancer TreatmentThe TIGIT target, once hailed as the "next PD-1", has garnered significant attention in the field of immunotherapy. However, its development journey has been fraught with challenges, with numerous pharmaceutical companie...
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How do we dissolve BSA?Bovine Serum Albumin (BSA) is a globulin found in bovine serum, containing 607 amino acid residues, with a molecular weight of 66.446 kDa. It plays significant roles in blood circulation, lipid metabolism, detoxification...
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A Comprehensive Guide to Monoclonal Antibody ProductionMonoclonal antibodies (mAbs) have revolutionized medicine, diagnostics, and research since their discovery. The monoclonal antibody market has seen remarkable growth, estimated to reach over $250 billion globally by 2028...
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ACVR2A and ACVR2B as Key Targets for Muscle Growth, Weight Loss, PHA in Drug Research！Lately, Supercede Therapeutics announced a $100 million partnership with Fudan University and East China Normal University to develop ActRII inhibitors for treating muscle atrophy, potentially in combination with GLP-1 d...
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What Is Compartment Modelling in Pharmacokinetics?In the intricate world of pharmacokinetics, understanding how drugs move through the body is akin to unraveling a complex mystery. Compartment modeling is the key that unlocks this enigma, allowing researchers to visuali...
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Glycolysis Pathway: The Essential Energy Source for Cells, Even in Low-Oxygen ConditionsThe glycolysis pathway is a fundamental metabolic process that breaks down glucose to generate energy, ensuring cell survival and function. This pathway is unique in its ability to produce ATP, the primary energy carrier...
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