BDCA2/CLEC4C: a Novel Plasma Cell-Like Dendritic Cell (pDC) Marker and Potent Inhibitor of IFN-I that Blocks SLE Development!Recently, Rheumatology published a research paper entitled "An immunomodulatory antibody-drug conjugate (ADC) targeting BDCA2 strongly suppresses pDC function and glucocorticoid responsive genes. glucocorticoid responsiv...
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GLP-1R: An Energy Metabolism Regulator of GPCR Family, an Effective Drug Target for Type 2 Diabetes Therapy!GLP-1R, a member of the GPCR family B, has become a prominent focus in drug discovery due to its remarkable ability to regulate glucose and energy metabolism. Its pivotal role in managing diabetes and obesity, with benef...
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DKK1: a Well-Characterized Wnt Inhibitor, a Multifunctional Regulator in Multiple Cancers!Recently, DKK1 has garnered attention in tumor therapy due to promising clinical studies. Junshi Biosciences' JS015 injection, a humanized anti-DKK1 monoclonal antibody for advanced malignant solid tumors, received IND a...
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CEACAM6: a Potent CEA Family Molecule, a New Tumor Marker or Anti-Cancer Target!A recent article published in the American Journal of Respiratory and Critical Care Medicine reveals that CEACAM6 is a key inhibitor of HO-1 inhibitor that contributes to the development of lung disease [1]. Carcinoembry...
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MYL9: a New Member of Myosin Motors, a Key Driver of Cancer Cell Dynamic Regulation?MYL9, the regulatory light chain of myosin, is essential for cell movement by activating myosin motility. It has been shown that MYL9 promotes cancer cell migration and is implicated in tumor development and progression....
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SIGIRR: A Novel Member of the TIR Superfamily Acts as the Anti-Inflammatory 'Brake' to Control Immune Response in Various Diseases!Lately, the journal Seminars in Immunology published an intriguing article titled "IL-1R8: A Molecular Brake for Anti-Tumor and Anti-Viral Activity of NK Cells and ILCs" [1]. The study highlights the significance of IL-1...
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The Power and Promise of Stable Cell LinesThe HeLa cell line, the first immortalized human cell line, was established in 1951 [1]. In 1975, hybridoma technology enabled the generation of stable hybridoma cell lines producing monoclonal antibodies [2]. Recombinan...
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TFR1 (TFRC): a Stimulator of Fe Transport Affects Anemia, Neurodegenerative Disorders and Cancers!Transferrin receptor TFR1 is one of the key members mediating the entry of iron ions into cellular channels and plays a critical role in regulating cellular iron metabolism and maintaining iron homeostasis. Cancer cells ...
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GIPR: the Crucial Regulator of Glucose and Lipid Metabolism in Diabetes and Obesity!GIPR has garnered significant attention lately. According to Pharmsnap clinical database, a GIPR target drug (Tirzepatide) has already entered the market in China for treating type 2 diabetes, obesity, and cardiovascular...
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Microglial Markers: Insights into Microglial Activation and FunctionGerman physician and psychiatrist Pío del Río-Hortega first discovered microglia in 1919. Initially thought to be static and supportive cells in the central nervous system (CNS), subsequent research revealed their dyna...
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