Bladder Cancer, A Malignancy that Favors MenBladder cancer is a common malignancy in women and is the fourth most common malignancy in men [1]. Men's risk is 3-4 times that of women. In 2020, the American Cancer Society estimates that there will have been approxim...
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The Metabolic Phenotype of Tumor-Associated Macrophages in the Tumor MicroenvironmentIt is well-recognized that inflammation and immune escape are two hallmarks of tumors. Importantly, tumor-associated macrophages (TAMs), tumor-associated neutrophils (TANs), and bone marrow-derived suppressor cells (MDSC...
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Endometrial Cancer, a Female Killer That is Easily IgnoredThe uterus is the hollow, pear-shaped pelvic organ where fetal development occurs. It is very vulnerable to various diseases. Endometrial cancer is one of them, a malignant tumor that occurs in the uterus. It is one of t...
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Osteoprotegerin (OPG): What is Its Potential as a Biomarker or Therapeutic Target?On July 22, 2020, a study published in the journal Cell Death & Differentiation reveals a new regulation mechanism in terms of the osteoprotegerin (OPG). The research implies for the first time that osteoprotegerin (OPG)...
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Streptococcus pneumoniae, a Primary Cause of PneumoniaStreptococcus pneumoniae (S. pneumoniae) is a major cause of pneumonia, meningitis, sepsis and other serious illnesses worldwide. In November 2010, the WHO announced that between 700,000 and 1 million children under the ...
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The Multifunctional Enzyme CD38: A Target for Immunotherapeutic Approaches in CancerRecently, CD38 causes fresh concerns in the field of anti-aging because two articles published in Nature Metabolis point that CD38 attributes to the NAD+ consumption [1-2]. NAD support is called by some as the "immortali...
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Cervical Cancer, One of the Most Common Killers of WomenCancer of the uterine cervix, also called cervical cancer, is among the most preventable human malignancies, yet it remains a leading cause of death among women worldwide [1] [2]. According to the data from World Health ...
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An Overview of CD226 and Its Promising Role in Cancer ImmunotherapyNowadays, ample evidence has shown the roles of immune checkpoints in cancer immunotherapy. Intriguingly, CD226, a well-known active receptor, it is increasingly being recognized and researched through the two articles p...
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CD73, What a Powerful Therapy Target in Tumor ImmuneOn October 27, 2020, Akeso, Inc. announced the completion of its first clinical trial in New Zealand for its innovative drug candidate CD73 monoclonal antibody named AK119, which was administered to healthy subjects. AK1...
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With the High Potential in Cancer Immunotherapy, CD40 Is Triggering AttentionLast month saw the newest FDA-approved orphan drug APX005M, an anti-CD40 agonist antibody. The company Apexigen announced that FDA has granted orphan drug designation status to APX005M for the treatment esophageal and ga...
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