Tetraspanin CD81: a Key Receptor for Hepatitis C Virus (HCV), an Established Exosome Marker, a Promising Target for Antiviral or Antitumor Research!The journal Cancers recently published a paper titled "Targeting of Tetraspanin CD81 with Monoclonal Antibodies and Small Molecules to Combat Cancers and Viral Diseases" [1]. This paper highlights CD81 as a crucial targe...
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CRTAM: Class I Restricted T cell-associated Molecule, an Intriguing New Member of the Ig-SF Family!CRTAM is a recently discovered member of the immunoglobulin superfamily (Ig-SF), a group of proteins crucial for immune system formation, response, and cell interactions. It functions as a cell-surface transmembrane prot...
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TM4SF1: a Member of the Transmembrane-4-Superfamily (L6), a New Vascular Therapeutic Target?In recent years, TM4SF1 has become a key target for many cancers. As part of the TM4SF protein family, TM4SF1 interacts within and outside cells, influencing vital processes like signaling and cell movement. Studies reve...
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Anti-Payload Antibody DXD: A Highly Potent Tool for ADCs Pharmacokinetic (PK) Analysis!Pharmacokinetic (PK) assays play a pivotal role in pharmacology, offering essential insights into how drugs are absorbed, distributed, metabolized, and excreted in the body. They provide crucial understanding regarding d...
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MAGEA4: a Member of the Melanoma-Associated Antigen (MAGE) Family, a Popular Target for Tumor-Specific Immune Research!At the AACR 2023 Annual Meeting, AbCellera, a Canadian biotech company, shows their latest research , focusing on MAGE-A4. They introduced the T cell inducer (TCE) platform, featuring a bispecific antibody that binds to ...
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CEACAM5: A Promising Member of CEACAM Family, A Potential Target for ADC Drug Research!CEACAM5, a prominent tumor marker on various solid tumors, was highlighted at the European Lung Cancer Congress 2023 (ELCC2023). The event revealed encouraging outcomes of CEACAM5-targeted drug Tusamitamab ravtansine (SA...
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ALPG: a Germ Cell-Associated Alkaline Phosphatase (ALP), a Highly Specific Cell Surface Antigen in Cancers!Early, the journal Nature Reviews Clinical Oncology published a review article titled "Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours", which summarizes the latest advancements in mitig...
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DSG3: An Emerging Tumor-Associated Adhesion Factor, a Specific Marker for the Clinical Diagnosis of Pemphigus Vulgaris (PV)!DSG3 is part of the DSGs family (DSG1, DSG2, DSG3, DSG4) within the calcineurin superfamily of cell adhesion molecules. Recent research has highlighted the significance of adhesion molecules in relation to tumors. These ...
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ENPP3 (CD203c): An Extracellular Enzyme, a Regulator for Nucleotide and Energy, an Indicator for Allergies, an Effective Target for RCC Therapy!Lately, Xencor, Inc. has launched a clinical drug called AGS-16M8F12 (ENPP3 x CD3) to target ENPP3 in patients with metastatic renal cell carcinoma (RCC). This drug is being evaluated for its safety, pharmacokinetics, an...
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CNR1 (CB1): A Crucial Receptor of Endocannabinoid System Offers Potential Treatments for Tumors and Glycolipid Metabolism Disorders!Denmark's Novo Nordisk recently acquired Canadian biotech firm Inversago Pharma for up to $1.075 billion. The acquisition is focused on Inversago Pharma's innovative CB1 receptor (CB1R)-based therapy, INV-202. This move ...
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