CD69: a Classical Early Marker of Lymphocyte Activation, a Pivotal Regulator of Hematologic Diseases and Autoimmune Disorders!
CD69: a Classical Early Marker of Lymphocyte Activation, a Pivotal Regulator of Hematologic Diseases and Autoimmune Disorders!A research paper entitled “HSF1 promotes CD69+Treg differentiation to inhibit colitis progression” was recently published in the journal Theranostics [1]. The study found that knockdown of CD69 induced autoimmune dis...
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DSG2: a Vital Member of Desmosomal Cadherin Family, an Exciting New Target for Cardiomyopathy, Adenovirus, and Tumors!
DSG2: a Vital Member of Desmosomal Cadherin Family, an Exciting New Target for Cardiomyopathy, Adenovirus, and Tumors!DSG2 stands for desmoglein-2, which is a type of desmosomal cadherin protein. It is a well-established fact that mutations in a variety of desmogleins can lead to the development of cardiomyopathy, like Desmocollin-2, De...
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ULBP1: a Potent Member of NKG2D Ligands in CAR-T Therapy for Multiple Hematological and Solid Tumors!
ULBP1: a Potent Member of NKG2D Ligands in CAR-T Therapy for Multiple Hematological and Solid Tumors!Lately, the world-leading haematology journal the Lancet Haematology published a report [1], suggesting that administering multiple infusions of CYAD-01 without preconditioning exhibited both favorable efficacy and safet...
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IL-17A: A Major Cytokine of the IL-17 Family, a Key Inflammation Target in Skin Diseases, or Inflammation-Associated Cancers!
IL-17A: A Major Cytokine of the IL-17 Family, a Key Inflammation Target in Skin Diseases, or Inflammation-Associated Cancers!On March 25, 2023, China has achieved a significant milestone by successfully launching the first developed monoclonal antibody drug targeting IL-17A (Xeligekimab, GR1501). GR1501 is a human IL-17A-neutralizing IgG4 mono...
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Analysis of Factors Influencing ELISA Detection
Analysis of Factors Influencing ELISA DetectionELISA is a mature detection technology, which has been widely applied since its origin in the 19th century due to its unparalleled advantages. To achieve accurate, perfect, and reproducible experimental results, experime...
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Norwalk Virus
Norwalk VirusNorwalk virus, also known as Norovirus, is a common intestinal virus that can cause acute gastroenteritis. In recent years, Norwalk virus has become one of the main pathogens causing human gastrointestinal diseases, espe...
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Cadherin-17 (CDH17): A Viable Target in Bispecific Antibodies or CAR-T Therapy to Fight Many Gastrointestinal Cancers!
Cadherin-17 (CDH17): A Viable Target in Bispecific Antibodies or CAR-T Therapy to Fight Many Gastrointestinal Cancers!Recent years have seen an increasing research towards immunotherapy for gastrointestinal cancers (GICs), such as monoclonal antibodies, bispecific antibodies, and CAR-T cell therapy. Some targets identification lies at t...
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Exploring the Science of Influenza A Virus: What You Need to Know
Exploring the Science of Influenza A Virus: What You Need to KnowThe winter and spring seasons every year mark the peak period of influenza A virus outbreaks. Due to its numerous hosts in the natural environment and its high potential for mutation or recombination, each outbreak can c...
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LY6G6D (LY6-G): A New Member of Lymphocyte Antigen-6 Family Holds Big Opportunities in Bispecific Antibody for CRC Treatment!
LY6G6D (LY6-G): A New Member of Lymphocyte Antigen-6 Family Holds Big Opportunities in Bispecific Antibody for CRC Treatment!Genentech, an innovative leader in large molecule pharmaceuticals, has developed a anti-LY6G6D/CD3 bispecific antibody (LY6G6D-TDB) for colorectal cancer (CRC) treatment in its earlier days. With an elaborately design, L...
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CLDN3: Another Tight Junction Protein or New Drug Target, Interest in CLDN Family is Growing Fast!
CLDN3: Another Tight Junction Protein or New Drug Target, Interest in CLDN Family is Growing Fast!Now, as the Claudins continue to be explored, interest in emerging Claudins is growing fast! Claudins are the key constituent proteins of tight junction (TJ) proteins. TJ proteins play crucial roles of cell-cell adhesion...
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