ULBP1: a Potent Member of NKG2D Ligands in CAR-T Therapy for Multiple Hematological and Solid Tumors!Lately, the world-leading haematology journal the Lancet Haematology published a report [1], suggesting that administering multiple infusions of CYAD-01 without preconditioning exhibited both favorable efficacy and safet...
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IL-17A: A Major Cytokine of the IL-17 Family, a Key Inflammation Target in Skin Diseases, or Inflammation-Associated Cancers!On March 25, 2023, China has achieved a significant milestone by successfully launching the first developed monoclonal antibody drug targeting IL-17A (Xeligekimab, GR1501). GR1501 is a human IL-17A-neutralizing IgG4 mono...
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Analysis of Factors Influencing ELISA DetectionELISA is a mature detection technology, which has been widely applied since its origin in the 19th century due to its unparalleled advantages. To achieve accurate, perfect, and reproducible experimental results, experime...
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Norwalk VirusNorwalk virus, also known as Norovirus, is a common intestinal virus that can cause acute gastroenteritis. In recent years, Norwalk virus has become one of the main pathogens causing human gastrointestinal diseases, espe...
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Cadherin-17 (CDH17): A Viable Target in Bispecific Antibodies or CAR-T Therapy to Fight Many Gastrointestinal Cancers!Recent years have seen an increasing research towards immunotherapy for gastrointestinal cancers (GICs), such as monoclonal antibodies, bispecific antibodies, and CAR-T cell therapy. Some targets identification lies at t...
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Exploring the Science of Influenza A Virus: What You Need to KnowThe winter and spring seasons every year mark the peak period of influenza A virus outbreaks. Due to its numerous hosts in the natural environment and its high potential for mutation or recombination, each outbreak can c...
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LY6G6D (LY6-G): A New Member of Lymphocyte Antigen-6 Family Holds Big Opportunities in Bispecific Antibody for CRC Treatment!Genentech, an innovative leader in large molecule pharmaceuticals, has developed a anti-LY6G6D/CD3 bispecific antibody (LY6G6D-TDB) for colorectal cancer (CRC) treatment in its earlier days. With an elaborately design, L...
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CLDN3: Another Tight Junction Protein or New Drug Target, Interest in CLDN Family is Growing Fast!Now, as the Claudins continue to be explored, interest in emerging Claudins is growing fast! Claudins are the key constituent proteins of tight junction (TJ) proteins. TJ proteins play crucial roles of cell-cell adhesion...
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PROM1 (CD133): A New Cell Surface Marker of Cancer Stem Cells (CSCs), A More Significant Target for Immunotherapy!A study published in Science Translational Medicine recently made a big splash. The article entitled "Intracavity generation of glioma stem cell-specific CAR macrophages primes locoregional immunity for postoperative gli...
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TPBG/5T4: the Oncofetal Protein, an Appealing Target for ADC or Vaccine Therapeutics in Tumors!TPBG/5T4 has been so appealing recently to pharmaceutical companies as it yields encouraging results in tumor therapies. ClinicalTrial noted that there are over 10 TPBG-targeted drugs in clinical development. Notably, Ox...
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