Don't Let Hepatocellular Carcinoma "Favor" YouHepatocellular carcinoma (HCC) refers to cancer that originates in the liver, which is distinguished from "secondary" liver cancer that spreads from other organs to the liver. Hepatocellular carcinoma, which accounts for...
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A Switch that Controls the Entry and Exit of IonsIon channels are pore-forming proteins. It is a passive transport pathway for various inorganic ions across the membrane and an important way for living cells to carry out metabolic activities and material exchange. Ion ...
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G protein-Coupled Receptor - Targets for Drug TherapyG protein-coupled receptor (GPCR) is a general term for a large class of membrane protein receptors, which also known as seven α-helices transmembrane segment receptors (7TM receptors). It binds to extracellular molecul...
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The Overview of Fc Receptors- Classification, Related Signaling Pathways and ApplicationIn the global bio-pharmaceutical market and research & development, monoclonal antibody drugs are one of the most important categories. Monoclonal antibodies are characterized by high specificity, strong targeting and lo...
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A transport machine -- ATP-binding cassetteFigure 1 The Structure of ATP-binding cassette The picture is from wikipedia ATP-binding cassette (ABC) transporters are the largest known transmembrane protein superfamily, widely distributed in eukar...
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Human Leukocyte Antigen: Distinguish between Friend and FoeMHC proteins are found in all higher vertebrates. The glycoprotein encoded by human MHC is called human leukocyte antigen (HLA), which specifically presents short peptides to T cells and haves a key role in the immune de...
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CD Antigens - From Leucocytes Surface Markers to Diagnostic Markers for CancerCD antigens, also known as cell surface antigens of leukocytes or cluster of differentiation, are molecules originally defined as being present on the cell surface of leucocytes and recognized by specific antibody molecu...
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The Rare Disease-Huntington's DiseaseHuntington's disease (HD) is also known as "hereditary chorea" and "chronic progressive chorea" [1]. Huntington's disease is a hereditary neurodegenerative disease caused by an autosomal dominant mutation that causes the...
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Ice Bucket Challenge – Pay your attention to amyotrophic lateral sclerosisAmyotrophic lateral sclerosis (ALS) is a rapidly progressing, inevitably fatal neurological disease that attacks nerve cells responsible for the voluntary muscles. It is characterized by rapid degeneration and selective ...
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What Is Immune Checkpoint Therapy?Immune checkpoint therapy, mainly including anti‑CTLA‑4 therapy and anti‑PD‑1/PD‑L1 therapy, which targets regulatory pathways in T cells to enhance antitumor immune responses by blocking the inhibitory signals...
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