Interleukin-2 (IL2): The "Double-Edged Sword" of the Immune System1. What is Interleukin-2 (IL2)? Interleukin-2 (IL2) is a key immunoregulatory cytokine initially discovered for its ability to promote T cell proliferation. It plays a “double-edged sword” role in th...
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TSLP: A Key Target in Allergic and Inflammatory DiseasesThymic Stromal Lymphopoietin (TSLP) is a pleiotropic cytokine primarily secreted by epithelial cells in response to environmental stimuli such as allergens, viruses, or pollutants. It plays a pivotal role in immune regul...
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LYPD3: An Emerging Star in Solid Tumor Therapy1. Overview of LYPD3 LYPD3 (Ly6/PLAUR Domain-Containing Protein 3), also known as C4.4A, is a glycosylphosphatidylinositol (GPI)-anchored cell membrane protein that plays a key role in tumor progression,...
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MICA: key regulatory molecule for tumor immune surveillance and its therapeutic target potential1. What is MICA MICA (Major Histocompatibility Complex Class I-Related Chain A) is an important stress-inducing cell surface glycoprotein belonging to the MHC class I related protein family. The gene is ...
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MICB: a key molecule that bridges cellular stress and immune responses1. What is MICB 1.1 Molecular structure and localization Major histocompatibility complex class I chain-related protein B (MICB) is located on the short arm of human chromosome 6...
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B7-H6: A Key Ligand of NK Cell Immune Checkpoints Reshaping the Landscape of Tumor ImmunotherapyB7-H6, also known as Natural Cytotoxicity Triggering Receptor 3 Ligand 1 (NCR3LG1), is a unique member of the B7 co-stimulatory/inhibitory molecule family. It is not constitutively expressed in normal tissues but is sign...
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Colony Stimulating Factor 1 (CSF1): Its Key Role in Diseases and New Progress in Targeted TherapyColony-stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a key cytokine that plays a central role in the proliferation, differentiation, survival, and functional regulation of mo...
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Targeting LRRC15: From tumor microenvironment regulation to fibrotic/infectious disease therapyLRRC15 (leucine-rich repeat protein 15) is a transmembrane protein that plays an important role in tumor microenvironment regulation, viral infection mechanism, and fibrotic diseases. This article systematically expounds...
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PTH1R: Key Therapeutic Target in Bone & Metabolic Health | CUSABIOParathyroid Hormone 1 Receptor (PTH1R), a key member of the Class B G protein-coupled receptor (GPCR) family, is widely distributed in various tissues such as bones, kidneys, brain, and heart. As a central regulator of c...
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Immune Battlefield's "Scout": Decoding the NCR3 TargetThe global tumor immunotherapy market is expected to exceed $200 billion by 2025, and NCR3, as a key "switch" for NK cell activation, has become a highly sought-after target for pharmaceutical companies. Multinational dr...
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