Chemokine Receptor CCR6: the Specific Receptor for CCL20, a Potential Target for Drug Research in Inflammatory Diseases and Gastrointestinal Cancer!On January 3, 2024, a recent review titled "Research progress on the role of tumor-associated macrophages in tumor development and their use as molecular targets" sheds light on the pivotal role of tumor-associated macro...
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ACVRL1 (Alk1): a Member of the TGF-β Receptor Family, a Novel Target for Anti-Angiogenic Drug Research!Lately, the journal Nature Communications published a paper entitled "Alk1 acts in non-endothelial VE-cadherin+ perineurial cells to maintain nerve branching during hair homeostasis" [1], emphasizing the importance of TG...
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Tetraspanin CD81: a Key Receptor for Hepatitis C Virus (HCV), an Established Exosome Marker, a Promising Target for Antiviral or Antitumor Research!The journal Cancers recently published a paper titled "Targeting of Tetraspanin CD81 with Monoclonal Antibodies and Small Molecules to Combat Cancers and Viral Diseases" [1]. This paper highlights CD81 as a crucial targe...
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CRTAM: Class I Restricted T cell-associated Molecule, an Intriguing New Member of the Ig-SF Family!CRTAM is a recently discovered member of the immunoglobulin superfamily (Ig-SF), a group of proteins crucial for immune system formation, response, and cell interactions. It functions as a cell-surface transmembrane prot...
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TM4SF1: a Member of the Transmembrane-4-Superfamily (L6), a New Vascular Therapeutic Target?In recent years, TM4SF1 has become a key target for many cancers. As part of the TM4SF protein family, TM4SF1 interacts within and outside cells, influencing vital processes like signaling and cell movement. Studies reve...
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Anti-Payload Antibody DXD: A Highly Potent Tool for ADCs Pharmacokinetic (PK) Analysis!Pharmacokinetic (PK) assays play a pivotal role in pharmacology, offering essential insights into how drugs are absorbed, distributed, metabolized, and excreted in the body. They provide crucial understanding regarding d...
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MAGEA4: a Member of the Melanoma-Associated Antigen (MAGE) Family, a Popular Target for Tumor-Specific Immune Research!At the AACR 2023 Annual Meeting, AbCellera, a Canadian biotech company, shows their latest research , focusing on MAGE-A4. They introduced the T cell inducer (TCE) platform, featuring a bispecific antibody that binds to ...
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CEACAM5: A Promising Member of CEACAM Family, A Potential Target for ADC Drug Research!CEACAM5, a prominent tumor marker on various solid tumors, was highlighted at the European Lung Cancer Congress 2023 (ELCC2023). The event revealed encouraging outcomes of CEACAM5-targeted drug Tusamitamab ravtansine (SA...
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ALPG: a Germ Cell-Associated Alkaline Phosphatase (ALP), a Highly Specific Cell Surface Antigen in Cancers!Early, the journal Nature Reviews Clinical Oncology published a review article titled "Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours", which summarizes the latest advancements in mitig...
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DSG3: An Emerging Tumor-Associated Adhesion Factor, a Specific Marker for the Clinical Diagnosis of Pemphigus Vulgaris (PV)!DSG3 is part of the DSGs family (DSG1, DSG2, DSG3, DSG4) within the calcineurin superfamily of cell adhesion molecules. Recent research has highlighted the significance of adhesion molecules in relation to tumors. These ...
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