Colony Stimulating Factor 1 (CSF1): Its Key Role in Diseases and New Progress in Targeted TherapyColony-stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a key cytokine that plays a central role in the proliferation, differentiation, survival, and functional regulation of mo...
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Targeting LRRC15: From tumor microenvironment regulation to fibrotic/infectious disease therapyLRRC15 (leucine-rich repeat protein 15) is a transmembrane protein that plays an important role in tumor microenvironment regulation, viral infection mechanism, and fibrotic diseases. This article systematically expounds...
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PTH1R: Key Therapeutic Target in Bone & Metabolic Health | CUSABIOParathyroid Hormone 1 Receptor (PTH1R), a key member of the Class B G protein-coupled receptor (GPCR) family, is widely distributed in various tissues such as bones, kidneys, brain, and heart. As a central regulator of c...
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Immune Battlefield's "Scout": Decoding the NCR3 TargetThe global tumor immunotherapy market is expected to exceed $200 billion by 2025, and NCR3, as a key "switch" for NK cell activation, has become a highly sought-after target for pharmaceutical companies. Multinational dr...
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CCL17: A Chemokine with Multiple Biological Functions1. Overview of CCL17 C-C motif chemokine 17 (also known as TARC) is a chemokine belonging to the CC subfamily, primarily involved in regulating immune cell migration, activation, and inflammato...
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How Do CTLA-4 Inhibitors Work? A Complete Guide for Early-Career ResearchersIn the 1990s, immunologists made an unexpected discovery: sometimes the most effective way to fight cancer isn't to boost immune responses, but to remove the natural controls that keep them in check. Think of th...
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Pioneering CAR-T Cell Therapy: Advancing Personalized Cancer TreatmentEmily Whitehead, diagnosed with relapsed acute lymphoblastic leukemia (ALL), was the first child to receive CAR-T therapy in 2012 after all standard treatments failed. The CAR-T cell therapy worked on Emily, and she is c...
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EDNRA: A Key Target for Disease-Associated Angioplasty, Tumor Invasion, and Metabolic Regulation1. About EDNRA Endothelin A receptor (Endothelin Receptor Type A, EDNRA), a member of the G protein-coupled receptor (GPCR) family, is mainly expressed in endothelial and smooth muscle cells an...
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DLL4: A Key Target for Angiogenesis RegulationRecently, Co.unlink Medicines and Compass Therapeutics announced that the phase II/III clinical trials of the VEGF/DLL4 bispecific antibody tovecimig (CTX-009/ES104) for second-line cholangiocarcinoma treatment have reac...
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Decoding Recombinant Protein Expression: Strategic Solutions & Practical InsightsRecombinant protein expression is a cornerstone of biotechnology. It powers drug development, studies in structural biology, and enzyme production. But let’s be honest, how many times have you stared at a gel showing n...
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