CEACAM1: An Emerging Multifunctional Target for Cancer-Immune ModulationCarcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1), also known as CD66a or Biliary Glycoprotein (BGP), belongs to the immunoglobulin superfamily and is widely present in various cells. It has multiple bi...
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MSTN: A Key Target for Targeted Therapy in Muscle Diseases​Recently, Keros Therapeutics, Inc. announced positive results from the Phase I clinical trial of KER-065 in patients with Duchenne muscular dystrophy, which for the first time confirmed its safety in patients with neurom...
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How the Tumor Microenvironment Fuels Cancer's Deadly EvolutionCancer is not an isolated collection of mutated cells. It exists and evolves within a highly dynamic and interactive ecosystem known as the tumor microenvironment (TME). The TME surrounds and sustains tumors, playing a c...
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PVR (CD155): A Key Factor in Tumor Immune Evasion and a Novel Therapeutic Target1. Background and Basic Functions of PVR PVR (CD155), a member of the immunoglobulin superfamily, is a cell surface glycoprotein initially identified as the receptor for poliovirus, hence its n...
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TNFRSF13C (BAFF-R): A Key Target for Immune Regulation and Disease TreatmentTNFRSF13C (BAFF-R), a member of the TNF receptor superfamily, is pivotal for immune regulation. This review delves into its background, mechanisms, signaling pathways, associated diseases, and drug development progress. ...
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How to Choose the Right Recombinant Protein for Your Experimental Model?Recombinant proteins play a critical role in modern biological research, with increasingly extensive applications ranging from basic studies and disease modeling to drug research and development. The ability to produce a...
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IL-6: A Central Factor in Cytokine Storms and a Health Alert for Infections and DiseasesInterleukin-6 (IL-6) is a cytokine with diverse biological activities, involved in immune regulation and inflammatory responses [1]. Research into IL-6's properties and its role in diseases is crucial for developing new ...
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How AI is Reshaping Biological Research? A Comprehensive Guide to Tools and Practical StrategiesThe rapid evolution of artificial intelligence (AI) technologies, particularly large language models (LLMs) like ChatGPT [1,2], Claude, Gemini [3], and Deepseek, has profoundly influenced all facets of life, including bi...
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TNFSF18: Unlocking New Frontiers in Cancer ImmunotherapyCAR-T cell therapy has shown remarkable efficacy in treating hematologic malignancies but faces challenges in solid tumors due to the immunosuppressive tumor microenvironment, which limits CAR-T cell proliferation, persi...
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CSF2/GM-CSF: A Key Molecule in Immune Regulation and Disease TreatmentIn recent years, CSF2 (Granulocyte-Macrophage Colony-Stimulating Factor, GM-CSF) has garnered significant attention in biomedical research. CSF2 plays a crucial role in immune regulation, inflammatory responses, and tumo...
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