Microglial Markers: Insights into Microglial Activation and FunctionGerman physician and psychiatrist Pío del Río-Hortega first discovered microglia in 1919. Initially thought to be static and supportive cells in the central nervous system (CNS), subsequent research revealed their dyna...
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What Do You Need to Know Before Researching Human Metapneumovirus?Human metapneumovirus (hMPV) is a respiratory virus that was first identified in 2001. It belongs to the Paramyxoviridae family and the Pneumovirus genus, which also includes respiratory syncytial virus (RSV). Human meta...
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Protein Phosphorylation: The Dynamic Language of Cellular RegulationProtein phosphorylation, the reversible addition of a phosphate group to specific amino acid residues in proteins, is a fundamental post-translational modification (PTM) that regulates numerous cellular processes. This e...
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CADM1: an Immunoglobulin Superfamily Molecule, a New Tumor Suppressor Gene!CADM1 is a cell adhesion molecule that belongs to the immunoglobulin superfamily, and it has a ubiquitous presence in the human body. Apart from its abundance in multiple normal tissues where it serves various functions,...
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CD69: a Classical Early Marker of Lymphocyte Activation, a Pivotal Regulator of Hematologic Diseases and Autoimmune Disorders!A research paper entitled “HSF1 promotes CD69+Treg differentiation to inhibit colitis progression” was recently published in the journal Theranostics [1]. The study found that knockdown of CD69 induced autoimmune dis...
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DSG2: a Vital Member of Desmosomal Cadherin Family, an Exciting New Target for Cardiomyopathy, Adenovirus, and Tumors!DSG2 stands for desmoglein-2, which is a type of desmosomal cadherin protein. It is a well-established fact that mutations in a variety of desmogleins can lead to the development of cardiomyopathy, like Desmocollin-2, De...
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ULBP1: a Potent Member of NKG2D Ligands in CAR-T Therapy for Multiple Hematological and Solid Tumors!Lately, the world-leading haematology journal the Lancet Haematology published a report [1], suggesting that administering multiple infusions of CYAD-01 without preconditioning exhibited both favorable efficacy and safet...
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IL-17A: A Major Cytokine of the IL-17 Family, a Key Inflammation Target in Skin Diseases, or Inflammation-Associated Cancers!On March 25, 2023, China has achieved a significant milestone by successfully launching the first developed monoclonal antibody drug targeting IL-17A (Xeligekimab, GR1501). GR1501 is a human IL-17A-neutralizing IgG4 mono...
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Analysis of Factors Influencing ELISA DetectionELISA is a mature detection technology, which has been widely applied since its origin in the 19th century due to its unparalleled advantages. To achieve accurate, perfect, and reproducible experimental results, experime...
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Norwalk VirusNorwalk virus, also known as Norovirus, is a common intestinal virus that can cause acute gastroenteritis. In recent years, Norwalk virus has become one of the main pathogens causing human gastrointestinal diseases, espe...
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