Technical Articles

Technical Support

In this part of technical support, you can find some articles about experimental techniques and experimental tools, involving the related topic of ELISA, protein, antibody and so on.

ELISA

• ELISA Data Analysis
• How to Do The Pre-experiment before Your ELISA Experiment
• Four Types of ELISA
• 11 tips for choosing your right ELISA kit
• Do you Often Trouble in These Problems of ELISA?
• Problems and Solutions in ELISA Experiments

Protein

• CUSABIO's Five Expression Systems
• General Information of Different Tags
• How to express a protein with bioactivity?
• How to choose a suitable expression vector?
• Applications of recombinant proteins
• Production of Recombinant Protein
• Protein Acetylation: An Important Post-translational Modification in Eukaryotic Cells

Antibody

• How to choose an antibody for scientific research?
• What is antibody?
• The difference between primary antibody and secondary antibody
• The meaning of irregular antibody screening
• Tag Antibodies, Your Good Partner in Protein Research
• How to Choose the Loading Control Antibodies?
• Neutralizing Antibody Stands Out Among Antiviral Therapies

Pathway Research

On this part of pathway research, you can find the picture of signaling pathway, research overviews, relevant products, and other articles about special topic.

Please click here to view all pathways.

Apoptosis

• Apoptosis mediated by mitochondria
• Apoptosis mediated by endoplasmic reticulum
• Apoptosisi mediated by death receptor
• Aesthetic Appreciation of Apoptosis Signal Pathway

TGF-β Signaling Pathway

• The Overview of TGF-β Signaling Pathway
• Do You Really Know TGF-β Superfamily?
• Double-Edged Sword: TGF-β

Autophagy

• The Overview of Autophagy
• Crosstalk Between Autophagy and Apoptosis

Wnt Signaling Pathway

• The Overview of Wnt Signaling Pathway

PI3-Akt Signaling Pathway

• The Overview of PI3-Alt Signaling Pathway

Hippo

• The Overview of Hippo Signaling Pathway

Cytokines

Cytokines are a large group of proteins that are important in cell signaling. Their release has an effect on the behavior of cells around them. It can be said that cytokines are involved in autocrine signaling, paracrine signaling and endocrine signaling as immunomodulating agents. Cytokines may include growth factors, chemokines, interferons, interleukins, colony-stimulating factors, and tumour necrosis factors(despite some overlap in the terminology). Cytokines are produced by a broad range of cells, including immune cells like macrophages, B lymphocytes, T lymphocytes and mast cells, as well as endothelial cells, fibroblasts, and various stromal cells; a given cytokine may be produced by more than one type of cell.

Tumour Necrosis Factor

• The Overview of Tumour Necrosis Factor
• Related Products

Chemokine

• The Overview of Chemokine
• Related Products

Interleukin

• The Overview of Interleukin
• Related Products

Colony-stimulating Factor

• The Overview of Colony Stimulating Factors
• Related Products

Interferon

• The Overview of Interferon
• Related Products

Growth Factor

• The Overview of Growth Factor
• Related Products

Cancer

Cancer is a group of diseases that involve abnormal cell growth with the potential to invade or spread to other parts of the body. They form a subset of neoplasms. Comparing with benign tumors, which do not spread to other parts of the body. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often form a mass or lump, but may be distributed diffusely.

Click the following link to view related targets of cancer therapy: https://www.cusabio.com/drug-target-protein.html.

Melanoma

• Melanoma, the Most Serious Type of Skin Cancer

Leukemia

• Leukemia, Why is it So Common?

Endometrial Cancer

• Endometrial Cancer, a Female Killer That is Easily Ignored

Bladder Cancer

• Bladder Cancer, A Malignancy that Favors Men

Cervical Cancer

• Cervical Cancer, One of the Most Common Killers of Women

Ovarian Cancer

• Ovarian Cancer -- The Silent Killer

Tumor Marker

• The Overview of Tumor Markers
• Oncogenes and Cancer

Pancreatic Cancer

• FAP may be a drug target for pancreatic cancer

Prostate Cancer

• Role of non-coding RNA in prostate cancer progression

Breast Cancer

• Breast Cancer Signaling Pathway
• The Overview of Breast cancer-Related Signaling Pathways, Therapeutic Targets

Colorectal Cancer

• TASIN represents a promising approach for prevention of colorectal cancer

Hepatocellular Carcinoma

• Don't Let Hepatocellular Carcinoma "Favor" You
• Introduction of Hepatocellular Carcinoma Related Signaling Pathways

Gastric Cancer

• The Overview of Gastric Cancer

Lung Cancer

• What You Have To Know about Lung Cancer

Thyroid Tumor

• About Thyroid Tumor, This Information You Must Know!

Transmembrane Proteins

Transmembrane proteins are a group of integral membrane proteins that attach the biological membrane permanently. Many transmembrane proteins function as gateways to permit specific substances to across the biological membrane. They frequently undergo significant conformational changes to move a substance through the membrane.

Aquaporin

• The Nature of Detergent and Its Application in Membrane Proteins
• The Application of Nanodiscs in Membrane Proteins
• Transmembrane protein series one: Aquaporin

Ion Channels

• A Switch that Controls the Entry and Exit of Ions
• Transmembrane protein series two: Ion Channels

G protein-Coupled Receptor

• G protein-Coupled Receptor - Targets for Drug Therapy
• Transmembrane protein series three: G protein-Coupled Receptor

ATP-binding Cassette

• A Transport Machine -- ATP-binding Cassette
• Transmembrane protein series four: ATP-binding cassette transporters

Human Leukocyte Antigen

• Human Leukocyte Antigen: Distinguish between Friend and Foe
• Transmembrane protein series five: Human leukocyte antigen (HLA)

Chemokine Receptors

• Related Products of CUSABIO Chemokine Receptor
• Chemokine Receptors – One Kind of Powerful Seven Transmembrane Spanning G Protein-coupled Receptor

Transmembrane Proteins

• A Resume for Transmembrane Proteins

Neurological Research

Neuroscience, also known as a science of nervous system, is a branch of medicine dealing with disorders of the nervous system. Neurology deals with the diagnosis and treatment of all categories of conditions and disease involving the central and peripheral nervous systems (and their subdivisions, the autonomic and somatic nervous systems), including their coverings, blood vessels, and all effector tissue, such as muscle.

Nerve Markers

• Do You Really Know Neurons and Glia Cells in Nerve System?
• Neuronal Markers and Neurodegenerative Diseases

Neurodegeneration

• What You Should Know the Common Sense of Neurodegeneration

Alzheimer's disease

• The Memory thief - Alzheimer's disease

Parkinson's disease

• A "trembling" Parkinson's Disease

Amyotrophic Lateral Sclerosis

• Ice Bucket Challenge – Pay your attention to amyotrophic lateral sclerosis

Huntington's disease

• The Rare Disease - Huntington's Disease

Infectious Disease

Infectious disease, also known as transmissible disease or communicable disease, is illness resulting from an infection. Infections are caused by infectious agents including viruses, viroids, prions, bacteria, nematodes such as parasitic roundworms and pinworms, arthropods such as ticks, mites, fleas, and lice, fungi such as ringworm, and other macroparasites such as tapeworms and other helminths.

Common Virus

• The Encyclopedia of Common Virus

Influenza

• Please Take It Seriously-Influenza

Hepatitis

• Understanding Hepatitis, Fighting Hepatitis

Human Immunodeficiency Virus

• One World, One Hope—What Can We Do about AIDS?

Streptococcus Pneumoniae

• Streptococcus pneumoniae, a Primary Cause of Pneumonia

2019 Novel Coronavirus

• 2019 Novel Coronavirus
• What You Have to Know about Cytokine Storm and Virus Infection
• ACE2, The Hottest Target of SARS-CoV-2 Invasion
• CD147, a New Target of SARS-CoV-2 Invasion
• Nanobody, what a Powerful Novel Antibody!
• TMPRSS2, an Activator for SARS-CoV-2 Invasion
• The Recently Emerged New Swine Influenza Virus -- G4 EA-H1N1
• New Mechanism, NRP1 Enhances the Ability of SARS-CoV-2 Infection

Databases

In the section of databases, you can find series of useful databases based your research direction, involving KEGG, Uniprot, TCGA and so on.

KEGG Database

• How to Inquire and Utilize the Signal Pathway on KEGG

SWISS-PROT Database

• SWISS-PROT: When and How to Use It

Tumor Databases

• These Tumor Databases You Have To Know

Fundamental Research Database

• Tools You Need For Fundamental Research

TCGA Database

• TCGA Database- A Good Partner of Researchers

Model Organism Database

• What Powerful Model Organism Databases

Cell Markers

Cell markers, also known as cell surface antigens, serve as monograms to help identify and classify cells. This section includes several types of cell, involving stem cells, macrophages, lymphocytes and so on.

Stem Cells

• Stem Cell-What a Miraculous Resource in Human Body

Macrophages

• Two Types of Macrophages: M1 and M2 Macrophages

Lymphocytes

• These Surface Markers Help You Identify Lymphocytes

Th17 Cells

• Differentiation of Th17 Cells

Th1 and Th2 Cells

• How Do Th1 and Th2 Cells Differentiate?

NK cells

• Surface Markers of Natural Killer Cells

Hematopoietic Stem Cell

• Hematopoietic Stem Cell Surface Marker

Treg Cell

• Identify Treg Cells. You Can Do This.

Mesenchymal Stem Cell

• Surface Markers of Mesenchymal Stem Cells

Cell Cycle

• A Group of Promising Proteins - Cell Cycle Markers

Therapeutic Targets

Therapeutic Targets refer to a series of specific molecular targets that are associated with cancer. Knowledge of these targets is helpful for molecular dissection of the mechanism of action of drugs, and these knowledge gives assistance to guide new drug design and the search of new targets.

SEMA4D

• SEMA4D/CD100: As an Important Immuno-regulator to Improve Immunotherapy

HER2

• The Oncogene HER2: a New Target for Drug-Resistant Tumors

STAT3

• STAT3: a Key Transcriptional Regulator in Cancer

ERBB3

• ERBB3/HER3: a New Target for Tumor Therapy, a Driver Gene of Multi-Tumors

MUC16

• MUC16 (CA125): a Promising Predictive Marker and Therapeutic Target in Cancer

TNFR1

• TNFR1: A Multifaceted Molecule in Cancer, Another Promising Therapeutic Target for COVID-19

NRG1

• NRG1 or NRG1 Fusions: an Intriguing Therapeutic Target in Diseases

CD47

• CD47, A New Target for Tumor Immune

ROR1

• ROR1, an Emerging Target for Tumor Immunotherapy

CD40

• With the High Potential in Cancer Immunotherapy, CD40 Is Triggering Attention

CD73

• CD73, What a Powerful Therapy Target in Tumor Immune

CD226

• An Overview of CD226 and Its Promising Role in Cancer Immunotherapy

CD38

• The Multifunctional Enzyme CD38: A Target for Immunotherapeutic Approaches in Cancer

OPG

• Osteoprotegerin (OPG): What is Its Potential as a Biomarker or Therapeutic Target?

G protein-Coupled Receptor

• G protein-Coupled Receptor - Targets for Drug Therapy

Transthyretin

• Knowledge about Transthyretin

Follicle-stimulating hormone receptor

• Effects of FSHR on Fertility and Tumors

Tumor Suppressor Gene p53

• The True Face of Tumor Suppressor Gene p53

CD46

• CD46, A Complement Regulator

B7 homolog 3 protein

• Costimulatory/Coinhibitory: Is B7-H3 An Enemy or A Friend?

Programmed death-1

• PD-1-- An Important Immune Checkpoint

CD22

• CD22- What A Powerful Co-receptor of B Cell Receptor

TNFRSF14

• Dual Role of TNFRSF14 in Immunology

CD14

• CD14-- A Membrane Receptor for Bacterial Lipopolysaccharides

CD31

• CD31- A Complex Function Molecule

EphA3

• EphA3-A Regulator of Cell Adhesion and Migration

MOA1

• MOA1-A Potential Cancer Therapy Target

Mesothelin

• Mesothelin: A Rising Star of Cancer Immunotherapy

CD146

• CD146, A Powerful Tumor Marker