A2M Research Reagents

Alpha-2-macroglobulin is a protein in humans that is encoded by A2M gene. Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

The following A2M reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

A2M Antibodies

A2M Antibodies for Homo sapiens (Human)

A2M Proteins

A2M Proteins for Rattus norvegicus (Rat)

A2M Proteins for Homo sapiens (Human)

A2M Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

A2M Proteins for Bos taurus (Bovine)

A2M Proteins for Mus musculus (Mouse)

A2M ELISA Kit

A2M ELISA Kit for Bos taurus (Bovine)

A2M ELISA Kit for Homo sapiens (Human)

A2M ELISA Kit for Rattus norvegicus (Rat)

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