Ager Research Reagents

Advanced glycosylation end product-specific receptor is a protein in humans that is encoded by AGER gene. Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity).

The following Ager reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

Ager Antibodies

Ager Antibodies for Homo sapiens (Human)

Ager Proteins

Ager Proteins for Mus musculus (Mouse)

Ager Proteins for Rattus norvegicus (Rat)

Ager Proteins for Homo sapiens (Human)

Ager Proteins for Bos taurus (Bovine)

Ager ELISA Kit

Ager ELISA Kit for Homo sapiens (Human)

Ager ELISA Kit for Mus musculus (Mouse)

Ager ELISA Kit for Rattus norvegicus (Rat)

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