CNR1

The CNR1 gene encodes cannabinoid receptor 1 (CB1), a key G protein-coupled receptor (GPCR) in the endocannabinoid system. Common aliases include CB-R and type 1 cannabinoid receptor. Predominantly expressed in the central nervous system (hippocampus, cerebellum), CB1 mediates endogenous cannabinoids (anandamide, 2-AG) to regulate neurotransmitter release (GABA, glutamate), controlling appetite, pain perception, mood, and motor function.
CB1 signals via Gαi/o pathways, inhibiting adenylate cyclase (reducing cAMP) and activating MAPK cascades. Dysregulation links to obesity (appetite dyscontrol), neuro病理性 pain, anxiety, and addiction. Drug development: rimonabant (anti-obesity reverse agonist) was withdrawn for psychiatric side effects, but newer peripheral CB1 modulators (avoiding central impacts) are explored for metabolic syndrome and non-alcoholic fatty liver disease.

Validated Data

CSB-MP005678HU is detected by Mouse anti-6*His monoclonal antibody.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CNR1 at 10 μg/ml can bind Anti-CNR1 recombinant antibody (CSB-RA005678MA01HU), the EC₅₀ is 41.72-63.54 ng/mL.

CNR1 Recombinant Monoclonal Antibody (CSB-RA005678MA01HU)

Validated Data

The Binding Activity of Huamn CNR1 with Anti-CNR1 recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CNR1(CSB-MP005678HU) at 10 μg/mL can bind Anti-CNR1 recombinant antibody, the EC₅₀ is 41.72-63.54 ng/mL.

The following CNR1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CNR1 Antibodies

CNR1 Proteins

CNR1 Antibodies

CNR1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA005678GA01HU	CNR1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA007048	CNR1 Antibody	Human,Mouse,Rat,Monkey	WB, IHC, IF, ELISA
CSB-PA005678LA01HU	CNR1 Antibody	Human	ELISA, WB
CSB-PA005678LB01HU	CNR1 Antibody, HRP conjugated	Human	ELISA
CSB-PA005678LC01HU	CNR1 Antibody, FITC conjugated	Human
CSB-PA005678LD01HU	CNR1 Antibody, Biotin conjugated	Human	ELISA
CSB-RA005678MA01HU	CNR1 Recombinant Monoclonal Antibody	Human	ELISA

CNR1 Antibodies for Zea mays (Maize)

Code	Product Name	Species Reactivity	Application
CSB-PA469624XA01ZAX	CNR1 Antibody	Zea mays (Maize)	ELISA, WB (ensure identification of antigen)

CNR1 Proteins

CNR1 Proteins for Zea mays (Maize)

Code	Product Name	Source
CSB-CF469624ZAX	Recombinant Zea mays Cell number regulator 1 (CNR1)	in vitro E.coli expression system
CSB-YP469624ZAX1 CSB-EP469624ZAX1 CSB-BP469624ZAX1 CSB-MP469624ZAX1 CSB-EP469624ZAX1-B	Recombinant Zea mays Cell number regulator 1 (CNR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CNR1 Proteins for Pelophylax esculentus (Edible frog) (Rana esculenta)

Code	Product Name	Source
CSB-CF657029RAW	Recombinant Rana esculenta Cannabinoid receptor 1 (cnr1)	in vitro E.coli expression system
CSB-YP657029RAW1 CSB-EP657029RAW1 CSB-BP657029RAW1 CSB-MP657029RAW1 CSB-EP657029RAW1-B	Recombinant Rana esculenta Cannabinoid receptor 1 (cnr1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CNR1 Proteins for Xenopus laevis (African clawed frog)

Code	Product Name	Source
CSB-CF770415XBE	Recombinant Xenopus laevis Cannabinoid receptor 1 (cnr1)	in vitro E.coli expression system
CSB-YP770415XBE1 CSB-EP770415XBE1 CSB-BP770415XBE1 CSB-MP770415XBE1 CSB-EP770415XBE1-B	Recombinant Xenopus laevis Cannabinoid receptor 1 (cnr1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CNR1 Proteins for Pan troglodytes (Chimpanzee)

Code	Product Name	Source
CSB-CF683301EQV	Recombinant Pan troglodytes Cannabinoid receptor 1 (CNR1)	in vitro E.coli expression system
CSB-YP683301EQV1 CSB-EP683301EQV1 CSB-BP683301EQV1 CSB-MP683301EQV1 CSB-EP683301EQV1-B	Recombinant Pan troglodytes Cannabinoid receptor 1 (CNR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CNR1 Proteins for Macaca mulatta (Rhesus macaque)

Code	Product Name	Source
CSB-CF758268MOW	Recombinant Macaca mulatta Cannabinoid receptor 1 (CNR1)	in vitro E.coli expression system
CSB-YP758268MOW1 CSB-EP758268MOW1 CSB-BP758268MOW1 CSB-MP758268MOW1 CSB-EP758268MOW1-B	Recombinant Macaca mulatta Cannabinoid receptor 1 (CNR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CNR1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF005678HU	Recombinant Human Cannabinoid receptor 1 (CNR1)	in vitro E.coli expression system
CSB-YP005678HU1 CSB-EP005678HU1 CSB-BP005678HU1 CSB-MP005678HU1 CSB-EP005678HU1-B	Recombinant Human Cannabinoid receptor 1 (CNR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP005678HU	Recombinant Human Cannabinoid receptor 1 (CNR1)-VLPs (Active)	Mammalian cell

CNR1 Proteins for Felis catus (Cat) (Felis silvestris catus)

Code	Product Name	Source
CSB-CF005678CA	Recombinant Cat Cannabinoid receptor 1 (CNR1)	in vitro E.coli expression system
CSB-YP005678CA1 CSB-EP005678CA1 CSB-BP005678CA1 CSB-MP005678CA1 CSB-EP005678CA1-B	Recombinant Cat Cannabinoid receptor 1 (CNR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CNR1 Proteins for Taricha granulosa (Roughskin newt)

Code	Product Name	Source
CSB-CF874041TAX	Recombinant Taricha granulosa Cannabinoid receptor 1 (CNR1)	in vitro E.coli expression system
CSB-YP874041TAX1 CSB-EP874041TAX1 CSB-BP874041TAX1 CSB-MP874041TAX1 CSB-EP874041TAX1-B	Recombinant Taricha granulosa Cannabinoid receptor 1 (CNR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CNR1 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF005678RA	Recombinant Rat Cannabinoid receptor 1 (CNR1)	in vitro E.coli expression system
CSB-YP005678RA1 CSB-EP005678RA1 CSB-BP005678RA1 CSB-MP005678RA1 CSB-EP005678RA1-B	Recombinant Rat Cannabinoid receptor 1 (Cnr1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CNR1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF005678MO	Recombinant Mouse Cannabinoid receptor 1 (Cnr1)	in vitro E.coli expression system
CSB-YP005678MO1 CSB-EP005678MO1 CSB-BP005678MO1 CSB-MP005678MO1 CSB-EP005678MO1-B	Recombinant Mouse Cannabinoid receptor 1 (Cnr1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CNR1 Proteins for Taeniopygia guttata (Zebra finch) (Poephila guttata)

Code	Product Name	Source
CSB-CF005678TKW	Recombinant Taeniopygia guttata Cannabinoid receptor 1 (CNR1)	in vitro E.coli expression system
CSB-YP005678TKW1 CSB-EP005678TKW1 CSB-BP005678TKW1 CSB-MP005678TKW1 CSB-EP005678TKW1-B	Recombinant Taeniopygia guttata Cannabinoid receptor 1 (CNR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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