CD6 is a crucial type 1 transmembrane glycoprotein, with its extracellular portion consisting of three cysteine-rich scavenger receptor domains that are highly glycosylated. It interacts with the immunoglobulin superfamily molecule CD166 (ALCAM) as its primary ligand. When CD6 binds to ALCAM, it activates the mitogen-activated protein kinase (MAPK) pathway, which is associated with T-cell activation, proliferation, differentiation, and survival. This interaction plays a pivotal role in maintaining immune homeostasis, regulating T-cell function, and facilitating trafficking. Research has shown that blocking the CD6-ALCAM pathway can inhibit the activation and trafficking of pathogenic T-cells, providing a novel therapeutic strategy for related diseases. Additionally, CD6 is involved in the interaction between thymocytes and stromal cells, as well as processes such as autoimmunity and graft-versus-host disease.
Validated Data
All lanes: CD6 antibody at 4μg/ml
Lane 1: Hela whole cell lysate
Lane 2: Jurkat whole cell lysate
Lane 3: HT-29 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 72, 69, 64, 65, 59, 61 kDa
Observed band size: 72 kDa
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA326953ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human thymus tissue using CSB-PA326953ESR1HU at dilution of 1:100
The following Cd6 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
Cd6 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA134350 | CD6 Antibody |
Human | ELISA,WB |
CSB-PA326953ESR1HU | CD6 Antibody |
Human | ELISA, WB, IHC |
CSB-PA326953ESR2HU | CD6 Antibody |
Human | ELISA, IHC |
CSB-PA006156 | CD6 Antibody |
Human | WB, ELISA |
CSB-PA070265 | CD6 Antibody |
Human | WB, ELISA |
Cd6 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP326953HU1 CSB-EP326953HU1 CSB-BP326953HU1 CSB-MP326953HU1 CSB-EP326953HU1-B |
Recombinant Human T-cell differentiation antigen CD6 (CD6), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |