FCRL6

Fc receptor-like 6 (FCRL6), also referred to as FCRH6, is a transmembrane member of the immunoglobulin superfamily. It is primarily expressed on natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). Its cytoplasmic domain harbors immunoreceptor tyrosine-based inhibitory motifs (ITIMs), which transduce inhibitory signals upon ligand engagement, modulating the effector functions of these immune cells.
FCRL6 dysregulation links to tumor immune evasion—elevated expression in the tumor microenvironment may dampen CTL/NK cell activity. Current drug development efforts target FCRL6 to reinvigorate anti-tumor immunity; monoclonal antibodies blocking FCRL6-ligand interactions are in preclinical studies to boost cytotoxic lymphocyte responses against various cancers.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP718779HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) FCRL6.

FCRL6 Antibody (CSB-PA718779ESR2HU)

Validated Data

Western blot
All lanes: FCRL6 antibody at 1.29μg/ml
Lane 1: Hela whole cell lysate
Lane 2: A549 whole cell lysate
Lane 3: Jurkat whole cell lysate
Lane 4: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 48, 46, 44, 35 kDa
Observed band size: 48 kDa

Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA718779ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA718779ESR2HU at dilution of 1:100

The following FCRL6 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

FCRL6 Antibodies

FCRL6 Proteins

FCRL6 Antibodies

FCRL6 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA718779LA01HU	FCRL6 Antibody	Human	ELISA
CSB-PA718779LB01HU	FCRL6 Antibody, HRP conjugated	Human	ELISA
CSB-PA718779LC01HU	FCRL6 Antibody, FITC conjugated	Human
CSB-PA718779LD01HU	FCRL6 Antibody, Biotin conjugated	Human	ELISA
CSB-PA718779ESR2HU	FCRL6 Antibody	Human	ELISA, WB, IHC

FCRL6 Proteins

FCRL6 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP718779HU	Recombinant Human Fc receptor-like protein 6 (FCRL6), partial	Yeast
CSB-EP718779HU	Recombinant Human Fc receptor-like protein 6 (FCRL6), partial	E.coli
CSB-BP718779HU	Recombinant Human Fc receptor-like protein 6 (FCRL6), partial	Baculovirus
CSB-MP718779HU	Recombinant Human Fc receptor-like protein 6 (FCRL6), partial	Mammalian cell

FCRL6 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF008559MO	Recombinant Mouse Fc receptor-like protein 6 (Fcrl6)	in vitro E.coli expression system
CSB-YP008559MO1 CSB-EP008559MO1 CSB-BP008559MO1 CSB-MP008559MO1 CSB-EP008559MO1-B	Recombinant Mouse Fc receptor-like protein 6 (Fcrl6), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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FCRL6

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