Mitogen-activated protein kinase 8 is a protein in humans that is encoded by MAPK8 gene. Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins.

MAPK8 Antibodies

MAPK8 Antibodies for Homo sapiens (Human)

MAPK8 Antibodies for Human

MAPK8 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

MAPK8 Proteins

MAPK8 Proteins for Homo sapiens (Human)

MAPK8 Proteins for Rattus norvegicus (Rat)

MAPK8 Proteins for Xenopus laevis (African clawed frog)

MAPK8 Proteins for Mus musculus (Mouse)

MAPK8 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

MAPK8 cDNA for Xenopus laevis (African clawed frog)

Code Product Name Vector Accession NO.
CSB-CL013466XBE mapk8 pUC NM_001086715.1

MAPK8 cDNA for Mus musculus (Mouse)

Code Product Name Vector Accession NO.
CSB-CL013466MO Mapk8 pUC NM_016700.4

MAPK8 cDNA for Danio rerio (Zebrafish) (Brachydanio rerio)

Code Product Name Vector Accession NO.
CSB-CL013466DIL mapk8b pUC NM_131721.1


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