The following MAPK8 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

MAPK8 Antibodies

MAPK8 Antibodies for Homo sapiens (Human)

MAPK8 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

MAPK8 Proteins

MAPK8 Proteins for Homo sapiens (Human)

MAPK8 Proteins for Rattus norvegicus (Rat)

MAPK8 Proteins for Xenopus laevis (African clawed frog)

MAPK8 Proteins for Mus musculus (Mouse)

MAPK8 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

MAPK8 Background

The MAPK8 gene encodes mitogen-activated protein kinase 8, an enzyme also known as JNK1 [1][2]. JNK1 is ubiquitously expressed [2]. As a serine/threonine-protein kinase, MAPK8/JNK1 is involved in various processes such as cell proliferation, differentiation, migration, transformation, and apoptosis. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1.
In turn, MAPK8/JNK1 phosphorylates many transcription factors, primarily components of AP-1 such as JUN, JDP2, and ATF2 and thus regulates AP-1 transcriptional activity, eventually inducing cell proliferation, differentiation and stress responses [3-6]. Recently, it was demonstrated that JNK1 signaling plays a crucial role in the central nervous system (CNS) and in the pituitary to control systemic glucose and lipid metabolism partially through regulation of hormones involved in growth and energy expenditure [7].

[1] Dérijard B, Hibi M, et al. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain [J]. Cell. 1994, 76 (6): 1025–37.
[2] Davis RJ. Signal transduction by the JNK group of MAP kinases [J]. Cell 2000;103:239–252.
[3] Gupta S, Barrett T, et al. Selective interaction of JNK protein kinase isoforms with transcription factors [J]. EMBO J. 1996, 15 (11): 2760–70.
[4] Dérijard B, Hibi M, et al. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain [J]. Cell 1994, 76: 1025–1037.
[5] Kyriakis J, Banerjee P, The stress-activated protein kinase subfamily of c-Jun kinases [J]. Nature 1994, 369: 156–160.
[6] Nishina H, Wada T, et al. Physiological roles of SAPK/JNK signaling pathway [J]. J Biochem. 2004 Aug;136(2):123-6.
[7] Belgardt BF1, Mauer J, et al. Novel roles for JNK1 in metabolism [J]. Aging (Albany NY). 2010 Sep;2(9):621-6.

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