MAPK8

Mitogen-activated protein kinase 8 is a protein in humans that is encoded by MAPK8 gene. Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins.

MAPK8 Antibodies

MAPK8 Antibodies for Homo sapiens (Human)

Code Product Name Species Reactivity Application
CSB-PA013466GA01HU MAPK8 Antibody Human,Mouse,Rat ELISA,WB,IHC
CSB-PA222139 MAPK8 Antibody Human,Mouse,Rat ELISA,WB
CSB-PA236755 MAPK8 Antibody Human,Mouse,Rat ELISA,WB
CSB-PA176985 MAPK8 Antibody Human,Rat ELISA,WB,IHC
CSB-PA282702 MAPK8 Antibody Human,Mouse,Rat ELISA,WB,IHC

MAPK8 Antibodies for Human

Code Product Name Species Reactivity Application
CSB-PA16759A0Rb MAPK8 Antibody Human ELISA, WB, IHC, IF
CSB-PA16759B0Rb MAPK8 Antibody, HRP conjugated Human ELISA
CSB-PA16759C0Rb MAPK8 Antibody, FITC conjugated Human ELISA
CSB-PA16759D0Rb MAPK8 Antibody, Biotin conjugated Human ELISA

MAPK8 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

Code Product Name Species Reactivity Application
CSB-PA013466XA01DIL MK08 Antibody Danio rerio (Zebrafish) (Brachydanio rerio) ELISA, WB (ensure identification of antigen)

MAPK8 Proteins

MAPK8 Proteins for Homo sapiens (Human)

Code Product Name Source
CSB-YP013466HU Recombinant Human Mitogen-activated protein kinase 8(MAPK8),Yeast Yeast
CSB-BP013466HU Recombinant Human Mitogen-activated protein kinase 8(MAPK8),partial Baculovirus
CSB-EP013466HU Recombinant Human Mitogen-activated protein kinase 8(MAPK8),Escherichia Coli E.coli
CSB-MP013466HU Recombinant Human Mitogen-activated protein kinase 8(MAPK8),Mammalian cell Mammalian cell

MAPK8 Proteins for Rattus norvegicus (Rat)

Code Product Name Source
CSB-YP013466RA Recombinant Rat Mitogen-activated protein kinase 8(Mapk8),Yeast Yeast
CSB-EP013466RA Recombinant Rat Mitogen-activated protein kinase 8(Mapk8),Escherichia Coli E.coli
CSB-BP013466RA Recombinant Rat Mitogen-activated protein kinase 8(Mapk8),Baculovirus Baculovirus
CSB-MP013466RA Recombinant Rat Mitogen-activated protein kinase 8(Mapk8),Mammalian cell Mammalian cell

MAPK8 Proteins for Xenopus laevis (African clawed frog)

Code Product Name Source
CSB-YP013466XBE Recombinant Xenopus laevis Mitogen-activated protein kinase 8(mapk8),Yeast Yeast
CSB-EP013466XBE Recombinant Xenopus laevis Mitogen-activated protein kinase 8(mapk8),Escherichia Coli E.coli
CSB-BP013466XBE Recombinant Xenopus laevis Mitogen-activated protein kinase 8(mapk8),Baculovirus Baculovirus
CSB-MP013466XBE Recombinant Xenopus laevis Mitogen-activated protein kinase 8(mapk8),Mammalian cell Mammalian cell

MAPK8 Proteins for Mus musculus (Mouse)

Code Product Name Source
CSB-YP013466MO Recombinant Mouse Mitogen-activated protein kinase 8(Mapk8),Yeast Yeast
CSB-EP013466MO Recombinant Mouse Mitogen-activated protein kinase 8(Mapk8),Escherichia Coli E.coli
CSB-BP013466MO Recombinant Mouse Mitogen-activated protein kinase 8(Mapk8),Baculovirus Baculovirus
CSB-MP013466MO Recombinant Mouse Mitogen-activated protein kinase 8(Mapk8),Mammalian cell Mammalian cell

MAPK8 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

Code Product Name Source
CSB-YP013466DIL Recombinant Danio rerio Mitogen-activated protein kinase 8(mapk8),Yeast Yeast
CSB-EP013466DIL Recombinant Danio rerio Mitogen-activated protein kinase 8(mapk8),Escherichia Coli E.coli
CSB-BP013466DIL Recombinant Danio rerio Mitogen-activated protein kinase 8(mapk8),Baculovirus Baculovirus
CSB-MP013466DIL Recombinant Danio rerio Mitogen-activated protein kinase 8(mapk8),Mammalian cell Mammalian cell

MAPK8 cDNA

MAPK8 cDNA for Xenopus laevis (African clawed frog)

Code Product Name Vector Accession NO.
CSB-CL013466XBE mapk8 pUC NM_001086715.1

MAPK8 cDNA for Mus musculus (Mouse)

Code Product Name Vector Accession NO.
CSB-CL013466MO Mapk8 pUC NM_016700.4

MAPK8 cDNA for Danio rerio (Zebrafish) (Brachydanio rerio)

Code Product Name Vector Accession NO.
CSB-CL013466DIL mapk8b pUC NM_131721.1

MAPK8 cDNA for Rattus norvegicus (Rat)

Code Product Name Vector Accession NO.
CSB-CL013466RA Mapk8 pUC NM_053829.1

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