Neurogenic locus notch homolog protein 2 is a protein in humans that is encoded by NOTCH2 gene. Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells

NOTCH2 Antibodies

NOTCH2 Antibodies for Homo sapiens (Human)

NOTCH2 Proteins

NOTCH2 Proteins for Homo sapiens (Human)

NOTCH2 Proteins for Mus musculus (Mouse)

NOTCH2 Proteins for Rattus norvegicus (Rat)


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