NRAS Research Reagents

GTPase NRas is a protein in humans that is encoded by NRAS gene. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

The following NRAS reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

NRAS Antibodies

NRAS Antibodies for Homo sapiens (Human)

NRAS Antibodies for Rattus norvegicus (Rat)

NRAS Antibodies for Xenopus laevis (African clawed frog)

NRAS Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

NRAS Proteins

NRAS Proteins for Cavia porcellus (Guinea pig)

NRAS Proteins for Mus musculus (Mouse)

NRAS Proteins for Homo sapiens (Human)

NRAS Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

NRAS Proteins for Sus scrofa (Pig)

NRAS Proteins for Gallus gallus (Chicken)

NRAS Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

NRAS Proteins for Xenopus laevis (African clawed frog)

NRAS Proteins for Monodelphis domestica (Gray short-tailed opossum)

NRAS Background

The NRAS gene provides instructions for making a protein called NRAS that is involved primarily in regulating cell division [1][2]. Through a process known as signal transduction, NRAS relays signals from outside the cell to the cell's nucleus. These signals instruct the cell to grow and divide (proliferate) or to mature and take on specialized functions (differentiate). The NRAS protein is a GTPase, which means it converts a molecule called GTP into another molecule called GDP. The NRAS protein acts as a switch, and it is turned on and off by the GTP and GDP molecules. To transmit signals, the NRAS protein must be turned on by binding to a molecule of GTP. The NRAS protein is inactive when it converts the GTP to GDP. When the protein is bound to GDP, it does not relay signals to the cell's nucleus. The NRAS gene belongs to a class of genes known as oncogenes belonging to the Ras family of oncogenes, which also includes two other genes: HRAS and KRAS. When mutated, oncogenes have the potential to cause normal cells to become cancerous. These proteins play important roles in cell division, cell differentiation, and apoptosis.

[1] Marshall CJ, Hall A, et al. A transforming gene present in human sarcoma cell lines [J]. Nature. 1982, 299 (5879): 171–3.
[2] Shimizu K, Goldfarb M, et al. Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line [J]. PNAS. 1983, 80 (2): 383–7.

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