PCLAF

PCLAF (PCNA clamp associated factor), also known as KIAA0052, is a protein involved in DNA replication and repair. It acts as a binding partner of PCNA, enhancing its function in DNA synthesis and maintaining genomic stability. PCLAF participates in the Fanconi anemia/BRCA pathway, a key mechanism for DNA cross - link repair.
Mutations in PCLAF have been associated with certain types of cancers, including breast and ovarian cancer, due to its role in DNA damage response. In drug development, targeting PCLAF is a potential strategy for cancer treatment. By inhibiting its interaction with PCNA, it may disrupt cancer cell replication, though further research is still needed to develop effective drugs.