PIK3CB

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform is a protein in humans that is encoded by PIK3CB gene. Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation.

PIK3CB Antibodies

PIK3CB Antibodies for Homo sapiens (Human)

PIK3CB Proteins

PIK3CB Proteins for Homo sapiens (Human)

PIK3CB Proteins for Mus musculus (Mouse)

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