PIK3CB Research Reagents

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform is a protein in humans that is encoded by PIK3CB gene. Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation.

The following PIK3CB reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

PIK3CB Antibodies

PIK3CB Antibodies for Homo sapiens (Human)

PIK3CB Proteins

PIK3CB Proteins for Homo sapiens (Human)

PIK3CB Proteins for Mus musculus (Mouse)

PIK3CB Background

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform is a protein in humans that is encoded by PIK3CB gene [1]. PI3KB is a component of phosphoinositide 3-kinase (PI3K) important in signaling pathways involving receptors on the outer membrane of eukaryotic cells. PI3KB phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. PI3KB is involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. PI3KB may also act downstream receptor tyrosine kinases. And it is required in different signaling pathways for stable platelet adhesion and aggregation. PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. PIK3CB is altered in 1% of all cancers with colon adenocarcinoma, prostate adenocarcinoma, breast invasive ductal carcinoma, lung adenocarcinoma, and cutaneous melanoma having the greatest prevalence of alterations.

[1] Hu P, Mondino A, Skolnik EY, Schlessinger J (Jan 1994). "Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85". Mol Cell Biol. 13 (12): 7677–88.

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