Recombinant Mouse Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Pik3cb), partial

1. The crucial role of p110beta and the more subtle role of p110alpha in the production of PIP3 molecular species following platelet stimulation has been demonstrated. PMID: 29902570
2. these results identify the PI3K-GSK3-SMAD1 axis as a central node integrating multiple signaling networks that govern bone formation and homeostasis. PMID: 26896753
3. Collectively, these findings provide a mechanistic account of how Rac1-dependent membrane raft localization regulates differential activation of distinct phosphoinositide 3-kinase isoforms and offer insight into why PTEN-deficient cancers depend on p110beta. PMID: 27700986
4. p110beta transduces GPCR signals in the context of coincident activation by an RTK. The p110beta-Gbetagamma interaction was also required for neutrophils to generate reactive oxygen species in response to the Fcgamma receptor-dependent recognition of immune complexes PMID: 27531651
5. PI3K signaling plays a modulatory role in the regulation of the transcriptional rhythm of the Dbp gene by targeting BMAL1 and CLOCK. PMID: 27022680
6. Myeloid neoplasia driven by PTEN loss is dependent on p110beta via p110beta-Rac-positive-feedback loop, and that disruption of this loop may offer a new and effective therapeutic strategy for PTEN-deficient leukaemia. PMID: 26442967
7. p110beta regulates the action of androgens, the male sex hormones, specifically in the Sertoli cells that surround the developing sperm, without affecting androgen action in other tissues. PMID: 26132308
8. Combined inhibition of PI3Kbeta and PI3Kgamma reduces fat mass by enhancing alpha-MSH-dependent sympathetic drive, thus perhaps a promising treatment for obesity. PMID: 25406378
9. These findings reveal a role for p110beta during myogenesis and demonstrate that long-term reduction of skeletal muscle p110beta impairs whole-body glucose tolerance without affecting skeletal muscle size or strength in old mice. PMID: 25605332
10. Platelet PI3Kbeta and GSK3 regulate thrombus stability at a high shear rate. PMID: 25398937
11. Pancreas-specific disruption of Pik3ca or Rac1, but not Pik3cb, prevented the development of pancreatic tumors in Kras(G12D/+);Ptf1a(Cre/+) mice. PMID: 25311989
12. Prostate tumor driven by polyomaviruses MT depends on p110alpha but not p110beta. PMID: 24991009
13. Both p110alpha and p110beta are involved in Akt signaling by IGF-1, but that it is the p110alpha isoform that is responsible for IGF-1-mediated potentiation of platelet function. PMID: 24903091
14. Genetic ablation of only 3 out of 4 PI3K p110 beta alleles is sufficient to block the development of skin hamartomas resulting from the complete loss of Pten in mice. PMID: 24131925
15. PTEN-null tumors appear to inherently depend on p110beta, the p110 isoform reliance of PTEN-deficient tumors may be altered by concurrent mutations that activate p110alpha. PMID: 24737887
16. p110beta subtype of PI3K, followed by activation of Ser473, may possibly participate in the regulation of macrophages activity by wear particles, ultimately resulting in the TNF-alpha secretion and osteolysis. PMID: 23584990
17. p110beta participated in CXCL12-mediated neural progenitor cell migration. PMID: 23606281
18. p110alpha acts as a negative regulator of beta cell exocytosis and insulin secretion, while p110beta is a positive regulator of insulin secretion through a mechanism separate from its catalytic activity PMID: 23568272
19. Activation of PI3K (p110beta and p85beta), and phospho-AKT (Ser473), participated in the regulation of activating macrophages by wear particles, ultimately resulting in the secretion of TNF-alpha. PMID: 23330804
20. Study investigated the regulation of the ubiquitous p110beta isoform of PI3K, implicated in G-protein-coupled receptor (GPCR) signaling, PTEN-loss-driven cancers, and thrombocyte function. Unexpectedly, RAS is unable to interact with p110beta, but instead RAC1 and CDC42 from the RHO subfamily of small GTPases bind and activate p110beta via its RAS-binding domain. PMID: 23706742
21. These results indicate that LPA-stimulated PKD2 phosphorylation requires PKCdelta and non-catalytic actions of PI3K p110beta, and provide new information with respect to GPCR-mediated signal transduction in myoblasts. PMID: 23252604
22. In mammalian cells, p110beta acts as a molecular sensor for growth factor availability and induces autophagy by activating a Rab5-mediated signaling cascade. PMID: 23434372
23. Phosphoinositide 3-kinase C2beta regulates RhoA and the actin cytoskeleton through an interaction with Dbl PMID: 22984590
24. a novel p110beta-based regulatory role in receptor-mediated PI3K activity and identify p110alpha as an important target for treatment of HER2-positive disease. PMID: 22802530
25. In primary and immortalized mouse fibroblast cell lines, both p110alpha and p110beta controlled steady-state PtdIns(3,4,5)P3 levels and Akt signalling induced by heterozygous PTEN loss. PMID: 22150431
26. data show that p110beta is essential for the ATP- and statin-induced effects and support a role of nuclear pAkt in cancer development. PMID: 22074824
27. results suggest that PI3K signaling in LepR PMV neurons is essential for leptin-induced alteration in cellular activity. PMID: 21917798
28. study shows that p110beta nuclear localization signal and p85beta nuclear export sequence regulate p85beta/p110beta nuclear localization, supporting the idea that nuclear, but not cytoplasmic, p110beta controls cell survival PMID: 21383062
29. PI3K p110-alpha, and not p110-beta, promotes liver steatosis in mice fed an HFD. PMID: 21464441
30. Neutrophil NADPH oxidase activation by Aspergillus fumigatus hyphal reactive oxygen species (ROS) responses is dependent on class IA phosphoinositide 3-kinase (PI3K)beta and PI3Kdelta catalytic subunits. PMID: 21257963
31. lipid kinase p110beta/p85beta elucidates an unusual SH2-domain-mediated inhibitory mechanism PMID: 21362552
32. Results unveil a previously unknown function for p110-beta as a positive regulator of autophagy in multicellular organisms. PMID: 21059846
33. activation of the p110beta PI3K isoform by c-Kit is required during spermatogenesis, thus opening the way to new treatments for c-Kit positive testicular cancers PMID: 20053680
34. In IL3-dependent hemopoietic progenitor cells (which express all four class I PI3K isoforms), genetic inactivation of either p110alpha or p110delta did not affect cell proliferation or survival or sensitize to p110beta or p110gamma inactivation PMID: 20534549
35. prostate-specific expression of a p110beta allele activated by myristoylation induces prostate intraepithelial neoplasia PMID: 20534477
36. role of p110beta isoform of PI3K in hypothalamic energy regulation PMID: 19883613
37. Overall, our results provide new evidence for the roles of p110 isoforms in promoting cellular proliferation and homeostasis, IGF-IR internalization, and in opposing apoptosis. PMID: 19834495
38. class I PI3Kbeta is a critical sensor of genomic integrity PMID: 20368419
39. PI3Kbeta is a potential target for antithrombotic drugs. PMID: 20065293
40. important role for PI3K p110 beta in regulating the avidity of high affinity integrin alpha(IIb)beta(3) receptors, necessary for the cellular transmission of contractile forces PMID: 19940148
41. Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase PMID: 11919689
42. p110beta is the major class I catalytic isoform required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by primary macrophages PMID: 12869549
43. p85 and p110 subunits of PI3-kinase play a role in NF-kappaB activation through interaction with tyrosine-phosphorylated I(kappa)B-alpha and contribute to tyrosine phosphorylation of p65 NF-kappaB PMID: 12870650
44. Type Ia phosphoinositide 3-kinase (PI3K) p110beta isoform has a key role in regulating the formation and stability of integrin alpha(IIb)beta(3) adhesion bonds, necessary for shear activation of platelets. PMID: 15834429
45. PI3Kalpha and -beta present distinct activation requirements and kinetics in G(1) phase, with a selective action of PI3Kalpha at the G(0)/G(1) phase transition PMID: 18285463
46. p110beta, which shows a much broader tissue distribution than the leukocyte-restricted p110gamma, could thus provide a conduit for GPCR-linked PI3K signaling in the many cell types where p110gamma expression is low or absent. PMID: 18544649
47. ablation of p110beta in the livers of the resulting mice leads to impaired insulin sensitivity and glucose homeostasis, while having little effect on phosphorylation of Akt PMID: 18594509
48. p110beta catalytic activity is required for PI3K signaling as well as to sustain long-term insulin signaling. In addition, PIK3CB(K805R) mice were protected in a model of ERBB2-driven tumor development. PMID: 18780892
49. PI3K isoforms can be differentially regulated in distinct cellular contexts, with the dominant role of the p110delta isoform in Akt phosphorylation and proliferation being lost upon cell immortalisation PMID: 19033389
50. These results show a selective function of PI3Kbeta in the control of DNA replication. PMID: 19416922

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KEGG: mmu:74769

STRING: 10090.ENSMUSP00000035037

UniGene: Mm.213128