ERO1B Antibody

Code CSB-PA774834LA01HU
Size US$166
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  • Western blot
    All lanes: ERO1B antibody at 3.2µg/ml
    Lane 1: MCF-7 whole cell lysate
    Lane 2: U251 whole cell lysate
    Lane 3: Mouse liver tissue
    Lane 4: U87 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 54, 17 kDa
    Observed band size: 54 kDa

  • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA774834LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA774834LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ERO1B Polyclonal antibody
Uniprot No.
Target Names
ERO1B
Alternative Names
Endoplasmic oxidoreductin-1-like protein B antibody; Endoplasmic reticulum oxidoreductin-1-like protein B antibody; ERO1; S. cerevisiae; homolog of; beta antibody; ERO1-L-beta antibody; ERO1-like beta (S. cerevisiae) antibody; ERO1-like protein beta antibody; ERO1B_HUMAN antibody; Ero1lb antibody; Oxidoreductin-1-L-beta antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human ERO1-like protein beta protein (101-400AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ERO1B Antibody (Product code: CSB-PA774834LA01HU) is Non-conjugated. For ERO1B Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA774834LB01HU ERO1B Antibody, HRP conjugated ELISA
FITC CSB-PA774834LC01HU ERO1B Antibody, FITC conjugated
Biotin CSB-PA774834LD01HU ERO1B Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis.
Gene References into Functions
  1. This peptide, Ac-VDTTD-AFC, was efficiently cleaved by purified caspase-2 and auto-activating caspase-2 in mammalian cells, and exhibited better selectivity for caspase-2 relative to caspase-3 than reagents that are currently available. PMID: 27919037
  2. GJB2 and ERO1LB are implicated in pancreatic cancer progression and can be used to predict patient survival PMID: 28177904
  3. upregulated in pancreatic neuroendocrine tumors PMID: 26765469
  4. In the present work, it was shown that recombinant human Ero1beta is twice as active as Ero1alpha in enzymatic assays. PMID: 21091435
  5. glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum PMID: 15161913
  6. analysis of Ero1beta tissue distribution and dimerization PMID: 16012172
  7. Ero1alpha and Ero1beta are retained in the endoplasmic reticulum by interactions with PDI and ERp44 PMID: 16677073
  8. the Ero FAD binding domain is critical for conformational stability, allowing Ero proteins to withstand stress conditions that cause client proteins to misfold PMID: 16822866
  9. The lack of correlation between changes in SAT adiponectin gene and protein expression and its circulating levels suggests that adipose tissue synthesis and release of adiponectin are highly regulated pathways. PMID: 18996753

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Subcellular Location
Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Note=The association with ERP44 may be essential for its retention in the endoplasmic reticulum.
Protein Families
EROs family
Tissue Specificity
Highly expressed in the digestive tract, including the duodenum and lower digestive tract. In the stomach, highly expressed in enzyme-producing chief cells (at protein level). In the pancreas, expressed in islets of Langerhans and, at lower levels, in enz
Database Links

HGNC: 14355

OMIM: 615437

KEGG: hsa:56605

STRING: 9606.ENSP00000346635

UniGene: Hs.558519

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