Recombinant Human C-C motif chemokine 2 protein(CCL2) (Active)

Code CSB-AP000821HU
Product Type Chemokine
Size Pls inquiry other sizesPurchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P13500
Image
Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias HC11, Monocyte chemotactic and activating factor, MCAF, Monocyte chemotactic protein 1, MCP-1
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 10-100 ng/ml.
Purity >96% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSMDHLDKQ TQTPKT
Research Area Immunology
Source E.Coli
Gene Names CCL2
Expression Region 24-99aa
Product Info Tag-Free
Mol. Weight 8.7 kDa
Protein Description Full Length of Mature Protein
PubMed ID 2923622; 2513477; 2465924; 2518726; 2357211; 1661560; 8107690; 10918580; 14702039; 15489334; 2648385; 2322286; 2071154; 8195247; 8627182; 8898111; 9792674; 9837883; 10587439; 10529171; 15033992; 23233732; 1857712; 8639605; 8989326; 16352737
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Function Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
Subcellular location Secreted
Pathway Chemokine signaling pathway
TNF signaling pathway
IL-17 signaling pathway
NOD-like receptor signaling pathway
AGE-RAGE signaling pathway in diabetic complications

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