Recombinant Human C-C motif chemokine 2 protein(CCL2) (Active)

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Code CSB-AP000821HU
Product Type Chemokine
Size US$112Purchase it in Cusabio online store
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Uniprot No. P13500
Lead Time 5-10 business days
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Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias HC11, Monocyte chemotactic and activating factor, MCAF, Monocyte chemotactic protein 1, MCP-1
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 10-100 ng/ml.
Purity >96% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSMDHLDKQ TQTPKT
Research Area Immunology
Source E.coli
Gene Names CCL2
Expression Region 24-99aa
Tag Info Tag-Free
Mol. Weight 8.7 kDa
Protein Description Full Length of Mature Protein
PubMed ID 2923622; 2513477; 2465924; 2518726; 2357211; 1661560; 8107690; 10918580; 14702039; 15489334; 2648385; 2322286; 2071154; 8195247; 8627182; 8898111; 9792674; 9837883; 10587439; 10529171; 15033992; 23233732; 1857712; 8639605; 8989326; 16352737
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Function Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
Subcellular Location Secreted
Protein Families Intercrine beta (chemokine CC) family
Tissue Specificity Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level).
Database Links

HGNC: 10618

OMIM: 158105

KEGG: hsa:6347

STRING: 9606.ENSP00000225831

UniGene: Hs.303649

Pathway Chemokine signaling pathway
TNF signaling pathway
IL-17 signaling pathway
NOD-like receptor signaling pathway
AGE-RAGE signaling pathway in diabetic complications

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