Recombinant Human C-C motif chemokine 2(CCL2)

Code CSB-EP004783HU
Product Type Recombinant Protein
Size US$1726
Uniprot No. P13500
Relevance Chotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Alias HC11Monocyte chemoattractant protein 1Monocyte chemotactic and activating factor ;MCAFMonocyte chemotactic protein 1 ;MCP-1Monocyte secretory protein JESmall-inducible cytokine A2
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence QPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT
Source E.coli
Gene Names CCL2
Expression Region 24-99aa
Tag Info N-terminal GST-tagged
Mol. Weight 35.7kDa
Protein Description Full Length of Mature Protein
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
Subcellular Location Secreted
Protein Families Intercrine beta (chemokine CC) family
Tissue Specificity Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level).
Database Links

HGNC: 10618

OMIM: 158105

KEGG: hsa:6347

STRING: 9606.ENSP00000225831

UniGene: Hs.303649

Pathway Chemokine signaling pathway
TNF signaling pathway
IL-17 signaling pathway
NOD-like receptor signaling pathway
AGE-RAGE signaling pathway in diabetic complications

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