Cdc42 Antibody

Code CSB-PA334771XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Cdc42 Polyclonal antibody
Uniprot No.
Target Names
Cdc42
Alternative Names
Cdc42 antibody; CG12530Cdc42 homolog antibody; EC 3.6.5.2 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Cdc42 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt and Frl, regulates photoreceptor cell morphogenesis. Together with Frl, has a role in the neuronal development of mushroom bodies.
Gene References into Functions
  1. Cdc42 controls protrusion formation in a cell non-autonomous manner. PMID: 28143705
  2. Cdc42 regulates binding of Crumbs protein to the Par-6 CRIB-PDZ module. PMID: 26894406
  3. We propose that the guanine nucleotide exchange factor GEFmeso is involved in a developmental process that requires the synergistic action of CDC42 and Rac1 during Drosophila development PMID: 25753922
  4. A proof-of-principle experiment in which the Cdc42 GTPase associates with its alleged partner WASp within neurons during the time and space that coincide with the newly developing CNS. PMID: 24586421
  5. The distinct buttoning mechanism we propose for dorsal vessel closure is elaborated through signaling pathways regulating Cdc42 activity in this cell type. PMID: 24949939
  6. Zir is necessary to activate the Rho-family GTPases Rac2 and Cdc42 during the Drosophila cellular immune response. PMID: 22634526
  7. Wsp activity in within the fly testis is mediated by the small GTPase Cdc42. PMID: 21652648
  8. Drosophila Rich (dRich), a conserved Cdc42-selective guanosine triphosphatase-activating protein (GAP), inhibits the Cdc42-Wsp pathway to stimulate postsynaptic Gbb release PMID: 21041451
  9. Recruitment of Cdc42 and Rac1 to the sites of filopodium and lamellipodium formation is Rab35 dependent and occurs by way of microtubule tracks. PMID: 20065041
  10. ACK family tyrosine kinase activity is a component of Dcdc42 signaling during dorsal closure in Drosophila melanogaster. PMID: 11997505
  11. Cdc42 is a regulator for multiple aspects of dendritic development in Drosophila PMID: 12716918
  12. Both Rac1 and Cdc42 activation induced large growth cones and long filopodia, but Cdc42 did so more efficiently than Rac1. Cdc42 is specifically involved in the regulation of actin filaments in growth cones. PMID: 14750960
  13. Rho GTPases may have partially overlapping functions during planar cell polarity generation PMID: 17616927
  14. Synaptic growth activated by growth factor signaling is controlled at an endosomal compartment via coordinated Nwk and Cdc42-dependent actin assembly. PMID: 18701694
  15. The Par complex acts as an effector for Cdc42 in controlling the endocytosis of apical proteins. PMID: 19064670
  16. we propose that Ephexin/Cdc42 couples synaptic Eph signaling to the modulation of presynaptic CaV2.1 channels PMID: 19249276
  17. study showed Cdc42 remains inactive in embryos during the 1st two-thirds of embryogenesis; in the central nervous system where Cdc42 activity first becomes upregulated, individual neurons display patterns restricted to specific subcellular compartments PMID: 19498173
  18. Cdc42 antagonizes Rho1 activity at adherens junctions to limit epithelial cell apical tension. PMID: 19805632

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Subcellular Location
Cell junction, adherens junction. Cell membrane; Lipid-anchor. Note=Adherens junctions of developing photoreceptor cells.
Protein Families
Small GTPase superfamily, Rho family, CDC42 subfamily
Database Links

KEGG: dme:Dmel_CG12530

STRING: 7227.FBpp0301153

UniGene: Dm.2867

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