Code | CSB-E14308r |
Size | 96T,5×96T,10×96T |
Price | Request a Quote or Start an on-line Chat |
Trial Size |
24T ELISA Kit Trial Size (Only USD$150/ kit) * The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now |
The product CSB-E14308r is a sandwich ELISA kit developed to measure levels of rat angiotensin-converting enzyme 2 (ACE2) in serum, plasma, or tissue homogenates. The enzyme-substrate chromogenic reaction is also used to amplify the signal and quantify the levels of the analyte through the intensity of the colored product. The color intensity positively correlates with the amount of ACE2 bound in the initial step.
ACE2 is a negative regulator of the renin-angiotensin system (RAS) and contributes to catalyzing the conversion of angiotensin II to angiotensin 1-7, thereby counterbalancing ACE activity. Increasing evidence demonstrates that the enzymatic activity of ACE2 plays a protective role in cardiovascular diseases. Loss of ACE2 can be detrimental, as it results in functional deterioration of the heart and progression of cardiac, renal, and vascular pathologies. ACE2 also acts as the key SARS coronavirus receptor and stabilizer of neutral amino acid transporters. ACE2 has recently been shown to act as a major receptor for the SARS-CoV-2 S protein enabling viral fusion and entry into the host cells.
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