Code | CSB-MA442659 |
Size | US$166 |
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Application | Recommended Dilution |
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IHC | 1:20-1:200 |
The production of this ESR1 monoclonal antibody involved the use of hybridoma technology. B cells were first isolated from the spleen of a mouse that was immunized with the synthesized peptide derived from human ESR1. These B cells were then fused with myeloma cells to form hybridomas. The hybridomas were screened to select the one that produces ESR1-specific antibodies continuously and then cultured in the mouse abdominal cavity. The ESR1 monoclonal antibody was purified from mouse ascites by affinity-chromatography, using a specific immunogen, to ensure high purity. This purified ESR1 monoclonal antibody has been validated for its effectiveness in ELISA and IHC applications.
ESR1 plays a crucial role in the regulation of the female reproductive system, bone metabolism, and cardiovascular system. ESR1 binds to estrogen and forms a complex that regulates the expression of target genes involved in cell proliferation, differentiation, and apoptosis. Dysregulation of ESR1 has been linked to various diseases, including breast cancer and osteoporosis.
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