ADIPOQ Antibody

Code CSB-PA618019YA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
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  • Western blot
    All lanes: ADIPOQ antibody at 2µg/ml
    Lane 1: NIH/3T3 whole cell lysate
    Lane 2: HL60 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 27 kDa
    Observed band size: 27 kDa

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA618019YA01HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) ADIPOQ Polyclonal antibody
Uniprot No. Q15848
Target Names ADIPOQ
Alternative Names 30 kDa adipocyte complement related protein antibody; 30 kDa adipocyte complement-related protein antibody; ACDC antibody; Acrp 30 antibody; ACRP30 antibody; ADIPO_HUMAN antibody; Adipocyte antibody; Adipocyte C1q and collagen domain containing protein antibody; Adipocyte complement related 30 kDa protein antibody; Adipocyte complement related protein of 30 kDa antibody; Adipocyte complement-related 30 kDa protein antibody; adipocyte-specific secretory protein antibody; Adiponectin antibody; Adiponectin precursor antibody; adiponectin; C1Q and collagen domain containing antibody; Adipoq antibody; Adipose most abundant gene transcript 1 antibody; Adipose most abundant gene transcript 1 protein antibody; Adipose specific collagen like factor antibody; ADIPQTL1 antibody; ADPN antibody; APM 1 antibody; apM-1 antibody; APM1 antibody; C1q and collagen domain-containing protein antibody; GBP 28 antibody; GBP28 antibody; Gelatin binding protein antibody; Gelatin binding protein 28 antibody; gelatin-binding protein 28 antibody; Gelatin-binding protein antibody; OTTHUMP00000210047 antibody
Raised in Rabbit
Species Reactivity Human, Mouse
Immunogen Recombinant Human Adiponectin protein (19-244AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

CXCR3 confers sorafenib resistance of HCC cells through regulating metabolic alteration and AMPK pathway. Y Ren,Am J Transl Res,2020

Applications: Western Blot
Sample type: Huh7 cells
Review: Compared to Huh7 cells, p-AMPKα/AMPKα ratio was significantly decreased, levels of adipocytokines including ACSBG1, ADIPOQ, ACSL4 were increased as well as intracellular level of lipid peroxidation product MDA was decreased in Huh7-SOR cells, as shown in above values.
PMID: 32269715

Target Data

Function Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
Gene References into Functions
  1. Serum adiponectin correlates negatively with bone density in type 2 diabetic osteoporotic postmenopausal women. PMID: 29853264
  2. The 276G gene of adiponectin may be a susceptibility gene of CHD, and the genotype GG may be related to the severity of this disease. PMID: 30311881
  3. Alongside insulin resistance, increased sympathetic activity is associated with and may modulate HMW adiponectin levels in women with polycystic ovary syndrome. PMID: 29428305
  4. The adiponectin +276G/T polymorphism may be associated with the development of Kawasaki disease. PMID: 30022756
  5. Genetic polymorphisms in the adiponectin gene of recipients (but not donors) are associated with early de novo posttransplant hepatic steatosis. PMID: 29863454
  6. Expression of adiponectin inhibit the proliferation of colorectal cancer HCT116 cells and induce cell arrest at G1/G0 phase and promote apoptosis. PMID: 29773108
  7. Adiponectin was negatively related only in obese subjects PMID: 30070872
  8. ADIPOQ gene SNP rs182052 was associated with antipsychotic-induced weight gain. PMID: 28327672
  9. the current study indicated that the adiponectin expression levels were higher in the osteoarthritis patients than in the healthy controls. PMID: 30115130
  10. Serum total adiponectin and gender-specific ADIPOQ variants predict CHD and IS, but not HF, independently of other risk factors in community-based patients with T2D. PMID: 29969725
  11. severely obese patients, adiponectin gene expression in visceral adipose tissue (VAT) is negatively correlated with serum levels of uric acid and is an independent determinant, together with anthropometric parameters of visceral obesity and serum adiponectin levels, of insulin resistance. PMID: 29645064
  12. Adiponectin and colon cancer: evidence for inhibitory effects on viability and migration of human colorectal cell lines. PMID: 29446048
  13. Our meta-analysis suggests that the rs1501299 polymorphism may play a protective role in hypertension in Caucasian subgroup PMID: 28181566
  14. Studied the association of SNPs in the adiponectin gene with coronary artery disease in 277 Tunisian patients with angiographically confirmed coronary artery disease. PMID: 29633340
  15. Increased cardiovascular disease risk is associated with ADIPOQ SNPs, rs266729 and rs2241766, but not associated with rs1501299 (meta-analysis). PMID: 29807528
  16. High ADIPOQ expression is associated with hypothyroidism. PMID: 28728192
  17. adiponectin 45T/G polymorphism is associated with diabetic cardiovascular complication in type 2 diabetes PMID: 29686595
  18. preoperative adiponectin levels correlate with postoperative complications after cancer surgery PMID: 29141566
  19. women with gestational diabetes showed significantly low adiponectin and high resistin levels when compared with control group. PMID: 29207892
  20. Late improvement of low-density lipoprotein cholesterol and adiponectin after transplant suggested that kidney transplant recipients may still have risk of cardiovascular events, especially in the first years. PMID: 27267514
  21. Findings suggest a significant association between variants in COL13A1, ADIPOQ, SAMM50, and PNPLA3, and risk of NAFLD/elevated transaminase levels in Mexican adults with an admixed ancestry. PMID: 29307798
  22. fetuin a to adiponectin ratio is more strongly associated with metabolic syndrome and its components than fetuin-A or adiponectin alone PMID: 28779425
  23. component of mid-trimester amniotic fluid; its concentration varies with maternal body mass index and subsequent development of preterm birth, fetal growth restriction, and respiratory distress syndrome PMID: 28708576
  24. Data suggest that first trimester measurement of adiponectin and 1,5-anhydroglucitol are potential early serum biomarkers for later onset of gestational diabetes; both serum levels are lower in women who later develop gestational diabetes than in women who do not. This study was conducted in Dublin, Ireland. PMID: 29328940
  25. Worse nutritional state in de novo heart failure patients is associated with higher adiponectin plasma levels. Their levels were upregulated in adipose cells after being nutrients-starved. These results may help us to understand the adiponectin paradox in heart failure. PMID: 29559829
  26. Adiponectin may be considered a biomarker of metabolic compensation, inversely associated with chronic low-grade inflammation. Circulating adiponectin is also associated with lower risk of adverse cardivascular events in patients with severe carotid stenosis. PMID: 29305337
  27. Review/Meta-analysis: circulating adiponectin levels were significantly higher in patients with rheumatoid arthritis, but there was no correlation with disease activity. PMID: 28205390
  28. ADIPOQ rs1501299 gene polymorphism is associated with an increased risk of new-onset diabetes mellitus after liver transplantation. PMID: 29291779
  29. Serum levels of adiponectin were significantly and negatively associated with bone mineral density in patients with knee osteoarthritis. PMID: 29343264
  30. Data suggest that higher consumption of bread and dairy products along with low intake of rice may be associated with increased serum adiponectin in Japanese women. PMID: 28637371
  31. Data suggest that plasma adiponectin levels in obese women with low REE (resting energy expenditure) are significantly lower compared to obese women with low REE and compared to normal weight women. PMID: 29017362
  32. Elevated plasma adiponectin concentrations were associated with both clinical and radiological disease severity in knee osteoarthritis patients. PMID: 26544540
  33. High ADIPOQ expression is associated with osteoporosis and arterial stiffness. PMID: 28646476
  34. Higher adiponectin levels were associated with a more favourable development of cardiovascular autonomic function in individuals with type 2 diabetes independently of multiple confounders. PMID: 29195493
  35. Low ADIPOQ expression is associated with obesity. PMID: 28087246
  36. Findings indicate that blood adiponectin concentration is more likely to be an epiphenomenon in the context of metabolic disease than a key determinant. PMID: 29237687
  37. elevated circulating total adiponectin levels were associated with lower 10-year cardiovascular disease risk in adults without previous cardiovascular disease PMID: 29039145
  38. in lumbar facet joint osteoarthritis, expression in the subchrondral bone decreased as the degeneration increased PMID: 29100514
  39. Data suggest that transient increases in plasma adiponectin levels and transient decreases in plasma leptin levels occur following high-intensity interval exercise in overweight and obese young women. These studies were conducted in Turkey in formerly sedentary women ages 20-30 years. PMID: 28857629
  40. Adipolin and adiponectin are cytokines that exert substantial impact on obesity, progression of atherosclerosis, insulin resistance, and glucose metabolism. PMID: 29452073
  41. This meta-analysis demonstrates that serum/plasma levels of adiponectin in type 1 diabetes mellitus, rheumatoid arthritis, and systemic lupus erythematosus patients were higher than those in normal controls, but not in ankylosing spondylitis patients. PMID: 28702765
  42. Data suggest that, in overweight and obese subjects, weight reduction induces changes in chemerin serum levels in parallel with adiponectin plasma levels; chemerin is down-regulated and adiponectin is up-regulated in both insulin-resistant and insulin-sensitive subjects after weight reduction; however, only changes in chemerin in insulin-sensitive subjects were found to be statistically significant. PMID: 28323510
  43. ADIPOQ rs182052 AA allele is associated with obesity. PMID: 28947843
  44. The current investigation demonstrated that, unlike the reduction in the levels of all the adiponectin isoforms and the high molecular weight (HMW) / total adiponectin (TA) ratio, an increased low molecular weight (LMW) / TA ratio was associated with T2D through its relation to insulin resistance. PMID: 29494595
  45. This study showed that homeostatic model assessment (HOMA)-insulin resistance (IR) but not HOMA-adiponectin was appropriate for diagnosing IR. PMID: 29217381
  46. Data suggest that vitamin D deficiency (indicated by low maternal 25(OH)D concentrations) in overweight/obese pregnant women at high-risk of gestational diabetes is associated with increased cardiometabolic risk during pregnancy and with adverse pregnancy outcomes; these associations may be mediated by HMW-adiponectin. PMID: 28741856
  47. The depigmenting effect of adiponectin was mediated via AMPK activation, which induced the inhibitory phosphorylation of CREB-regulated transcription co-activators (CRTCs) and subsequent suppression of the novel CRTC/CREB pathway in melanocytes. PMID: 28481450
  48. In anorexia nervosa subjects, TT genotype in ADIPOQ c.276 polymorphism was significantly more frequent than in control group. PMID: 28759190
  49. Our data suggest that adiponectin and resistin are altered in non-obese chronic migraineurs. PMID: 27553954
  50. An increased proportion of trunk fat is associated with decreased adiponectin in relatively overweight children, and also demonstrated that girls with a normal volume of body fat that follows a more centralized distribution show decreased adiponectin. PMID: 26655234
  51. Low ADIP [adiponectin] and high CRP [C-reactive protein] are associated with excessive %BF [body fat percent] and FG[fasting glucose] in AA [African Americans] women. ADIP/CRP, may be useful for detecting metabolic dysregulation. PMID: 29026382
  52. Adiponectin gene polymorphism (rs2241766) is a risk factor for type 2 diabetes mellitus in Iraqi population. The genotype distribution of rs2241766 SNP indicated a significant increase of carriers of the homozygous GG (OR: 5.04, CI95%: 2.27-11.19, P: 0.0001) and heterozygous TG (OR: 1.7, CI95%: 1.22-2.39, P: 0.002) variants . Results of rs822395 SNP failed to exhibit a significant difference PMID: 29627525
  53. The GG genotype of ADIPOQ gene variant (rs1501299) is associated with an increase in adiponectin levels and a decrease of insulin and HOMA-IR after weight loss. PMID: 29325772
  54. There was a direct association between the polymorphisms in LEP rs7799039 and ADIPOQ rs1501299 with overweight/obesity, and these genotypes affected the response to breast cancer chemotherapeutic treatment in Mexican women PMID: 28416193
  55. 16 studies containing 4,113 MS cases and 3,637 healthy controls indicated a weak positive association between ADIPOQ +45 T>G polymorphism and the metabolic syndrome in the dominant genetic model, which was also validated by stratified subgroup analyses. There was a strong association with metabolic-related disease. Adiponectin level was not a causal factor of increasing stroke risk. PMID: 27578536
  56. Genetic variation at the adiponectin gene, which influences adiponectin level, does not impact MS risk. PMID: 27903934
  57. We enrolled 43 stable coronary artery disease (CAD) male patients to examine the relationship between cystatin C-adiponectin (CysC-APN) complex and coronary plaque characteristics. In multivariate analysis, CysC-APN complex levels were identified as the strongest negative factor for fibrotic components and the strongest positive factor for both necrotic and lipidic plus necrotic components. PMID: 28321013
  58. High ADIPOQ expression is associated with ST-Segment Elevation Myocardial Infarction. PMID: 28100880
  59. Polymorphisms in rs1501299 and rs2241766, and their additional interactions between rs1501299 and smoking were associated with increased CHD risks: polymorphism in rs7649121 was associated with decreased CHD risks. PMID: 28737466
  60. data indicate that ADIPOQ rs266729 C>G polymorphism may contribute to the genetic risk of pre-diabetes and provide preliminary data useful in genetic screening for pre-diabetes among Thais. PMID: 29634196
  61. these data uncover that ADIPOQ/adiponectin induces autophagic cell death in breast cancer and provide in vitro and in vivo evidence for the integral role of STK11/LKB1-AMPK-ULK1 axis in ADIPOQ/adiponectin-mediated cytotoxic autophagy. PMID: 28696138
  62. Two polymorphisms, rs2241766 in ADIPOQ gene and rs10773989 in ADIPOR2 gene, especially under the recessive model of inheritance, played independent leading roles in susceptibility to myocardial infarction in Han Chinese. PMID: 29524572
  63. Non-T allele of ADIPOQ gene variant (rs1501299) is associated with increases in adiponectin levels and better improvements of insulin and HOMA-IR after biliopancreatic diversion surgery massive weight loss in morbid obesity. PMID: 28601987
  64. Severe, but not partial growth hormone deficiency impairs adiponectin production in the adipose tissue that is compensated by the increase of fat mass. PMID: 28650604
  65. Data suggest that, among patients with type 2 diabetes plus recent acute coronary syndrome, those with highest baseline adiponectin plasma levels are at highest risk of death from a cardiovascular event. PMID: 28195387
  66. Studied adiponectin (ADIPOQ), leptin (LEP), leptin receptor (LEPR), and resistin (RETN) single nucleotide polymorphisms and their association in obesity. Results showed that ADIPOQ 4522CPMID: 28195351
  67. Results show that adiponectin, resistin and visfatin are present in osteophytes but have no direct influence on osteophyte development. Although these adipokines induce several inflammatory mediators, they do not affect osteoblast- or chondrocyte-related mechanisms of osteophyte development. PMID: 27884778
  68. the association between adipokine levels and bone mineral density varies according to the menopause and central obesity status. PMID: 27873074
  69. In patients with chronic kidney disease, serum adiponectin concentration significantly correlated with aortic stiffness. PMID: 27514393
  70. This is the first study regarding the relationship of PPARGC1A and ADIPOQ polymorphisms, and the aggressiveness of prostate cancer in men with overweight or obesity. PMID: 28453464
  71. the SNPs +45T>G (rs2241766), -4034A>C (rs822395), and -11391G>A (rs17300539) were linked to Coronary Artery Disease development; +276G>T (rs1501299) SNP was associated with a decreased susceptibility to Coronary Artery Disease among Caucasians (Meta-Analysis) PMID: 28617663
  72. Dementia of neurodegenerative origin is characterized by elevated adiponectin levels. PMID: 28421328
  73. Frequency of ADIPOQ -11377 risk allele is low and does not functionally affect the serum adiponectin levels; hence, ADIPOQ C-11377G SNPis not a risk factor for T2DM in Pakistani Punjabi Rajput patients. PMID: 29056124
  74. results suggest weak associations between the studied variations in LEPR, RARRES2, and RETN genes and hand OA in Finnish women, and that the associations are modified by BMI PMID: 28812414
  75. The IL-6 and adiponectin concentrations were not significantly different between the two groups PMID: 28534699
  76. The development of type 2 Diabetes Mellitus in the Kyrgyz population is genetically determined by ADIPOQ (G276T) gene polymorphism with the predisposing value of the T allele of the heterozygous G276T genotype in the ADIPOQ gene. PMID: 29171469
  77. Endurance training was associated with increased insulin sensitivity in adipose tissue as well as skeletal muscle without changes in circulating adiponectin young, normal-weight Japanese women. PMID: 28318384
  78. analysis of naturally occurring mutations in ADIPOQ reveal insights into adiponectin biology including a possible compensatory mechanism to explain the clinically normal phenotype in G45R and R55C carriers who lack the HMW isoform PMID: 28643464
  79. Recombinant human globular adiponectin suppressed lipopolysaccharide (LPS)-primed inflammasomes activation in murine peritoneal macrophages judged by prevention of interleukin-1beta (IL-1beta) maturation, caspase-1 activation, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) speck formation, and pyroptotic cell death. PMID: 28617316
  80. During HCV infection, adiponectin affects insulin sensitivity through triglycerides and after viral clearance, adiponectin levels were directly associated with insulin sensitivity and decreased upon improved hepatic fibrosis. PMID: 28267407
  81. The current knowledge on regulation and function of adiponectin in obesity, insulin resistance, and cardiovascular disease is summarized in this review. [review] PMID: 28635626
  82. WZ4003 and SB203580 could suppress the APN-induced overexpression of CXCL1 and CXCL8. The results of the transwell chemotaxis assay also supported the above results. Our data suggest that APN can promote h-JBMMSC chemotaxis by up-regulating CXCL1 and CXCL8. PMID: 28176455
  83. Cord blood adiponectin is a useful biomarker for the prediction of adiposity at the age of 5 y. Plasma HMW adiponectin levels do not predict body fat distribution between 3-5 y. PMID: 28052063
  84. In a summary instrumental variable analysis (based on previously published data) with higher statistical power, no association between genetically determined twofold higher adiponectin and risk of colorectal cancer was observed (0.99, 95% CI 0.93, 1.06 in women and 0.94, 95% CI 0.88, 1.01 in men). Thus, our study does not support a causal effect of circulating adiponectin on colorectal cancer risk. PMID: 28550647
  85. Adiponectin and pro-inflammatory cytokines are associated with type 2 diabetes mellitus, and might serve as a prognostic marker and a therapeutic intervention for overweight-related type 2 diabetes mellitus. PMID: 27684566
  86. Decreased serum adiponectin levels were associated with risk factor for progression of pre-diabetes and type 2 diabetes in subjects. PMID: 28236525
  87. Serum adiponectin levels are inversely associated with cardiorespiratory fitness in nonoverweight, but not in overweight adolescents. In nonoverweight adolescents, those with highest levels of cardiorespiratory fitness (above healthy zone) presented lower levels of adiponectin compared with those in under and healthy cardiorespiratory fitness zones. PMID: 27834578
  88. Our results demonstrated that G allele of 211377C.G for adiponectin may be responsible for the decreased level of serum adiponectin which may apply as a potential index for the pathology for aneurysmal subarachnoid hemorrhage PMID: 26760913
  89. Data suggest that, compared to non-diabetic subjects, adults with type 1 diabetes had significantly higher levels of circulating adiponectin. PMID: 27368123
  90. the severity of metabolic syndrome exhibits long-term links to levels of insulin and adiponectin, suggesting potential genetic and environmental influences on insulin resistance over time PMID: 27133621
  91. Review/Meta-analysis: genetic polymorphisms in leptin, adiponectin and their receptors affect the development and progression of prostate cancer. PMID: 27768592
  92. The expression levels of adiponectin was significantly decreased in keloid fibroblasts. Adiponectin suppressed the CTGF-induced keloid fibroblast proliferation, migration and ECM production. PMID: 28498357
  93. The G allele of rs266729 in adiponectin gene increases the risk of type 2 diabetes mellitus through an additive genetic model with an effect of 1.13 PMID: 29381968
  94. Lower adiponectin levels together with higher blood pressure were independently associated with elevated carotid intima media thickness. Adiponectin concentration may be an independent marker of early structural damage in individuals at low-to-moderate cardiovascular risk. PMID: 27550907
  95. CRT inhibition significantly blunted APN's anti-oxidative action (evidenced by gp91(phox) expression and superoxide generation). However, CRT inhibition did not attenuate AMPK phosphorylation by APN administration in NCM. Therefore, these novel findings strongly indicate that APN exerts cardioprotective effects against I/R injury partially via CRT mediated anti-apoptotic and anti-oxidative actions. PMID: 27757734
  96. Lower plasma adiponectin levels were associated with major depressive disorder development in chronic hepatitis C patients. PMID: 27035148
  97. serum concentration correlated with blood pressure in obese children and increased in response to lifestyle intervention PMID: 27882931
  98. These findings are consistent with higher levels of serum leptin being associated with asthma regardless of age, and low adiponectin levels being associated with asthma in adults only. PMID: 27473714
  99. Greater than twofold likelihood of a Metabolically Unhealthy profile among the T allele carries of the adiponectin T45 T polymorphism relative to the G allele carriers was found in adults with Abdominal Obesity. PMID: 28593612
  100. To the best of our knowledge, the results showed that decreased adiponectin-mediated activity is associated with PTSD. Future studies are necessary to identify the causative role of adiponectin for PTSD as well as any possible covariates. PMID: 28662456

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Involvement in disease Adiponectin deficiency (ADPND); Diabetes mellitus, non-insulin-dependent (NIDDM)
Subcellular Location Secreted
Tissue Specificity Synthesized exclusively by adipocytes and secreted into plasma.
Database Links

HGNC: 13633

OMIM: 125853

KEGG: hsa:9370

STRING: 9606.ENSP00000320709

UniGene: Hs.80485

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