ADIPOQ Antibody, Biotin conjugated

1. Serum adiponectin correlates negatively with bone density in type 2 diabetic osteoporotic postmenopausal women. PMID: 29853264
2. The 276G gene of adiponectin may be a susceptibility gene of CHD, and the genotype GG may be related to the severity of this disease. PMID: 30311881
3. Alongside insulin resistance, increased sympathetic activity is associated with and may modulate HMW adiponectin levels in women with polycystic ovary syndrome. PMID: 29428305
4. The adiponectin +276G/T polymorphism may be associated with the development of Kawasaki disease. PMID: 30022756
5. Genetic polymorphisms in the adiponectin gene of recipients (but not donors) are associated with early de novo posttransplant hepatic steatosis. PMID: 29863454
6. Expression of adiponectin inhibit the proliferation of colorectal cancer HCT116 cells and induce cell arrest at G1/G0 phase and promote apoptosis. PMID: 29773108
7. Adiponectin was negatively related only in obese subjects PMID: 30070872
8. ADIPOQ gene SNP rs182052 was associated with antipsychotic-induced weight gain. PMID: 28327672
9. the current study indicated that the adiponectin expression levels were higher in the osteoarthritis patients than in the healthy controls. PMID: 30115130
10. Serum total adiponectin and gender-specific ADIPOQ variants predict CHD and IS, but not HF, independently of other risk factors in community-based patients with T2D. PMID: 29969725
11. severely obese patients, adiponectin gene expression in visceral adipose tissue (VAT) is negatively correlated with serum levels of uric acid and is an independent determinant, together with anthropometric parameters of visceral obesity and serum adiponectin levels, of insulin resistance. PMID: 29645064
12. Adiponectin and colon cancer: evidence for inhibitory effects on viability and migration of human colorectal cell lines. PMID: 29446048
13. Our meta-analysis suggests that the rs1501299 polymorphism may play a protective role in hypertension in Caucasian subgroup PMID: 28181566
14. Studied the association of SNPs in the adiponectin gene with coronary artery disease in 277 Tunisian patients with angiographically confirmed coronary artery disease. PMID: 29633340
15. Increased cardiovascular disease risk is associated with ADIPOQ SNPs, rs266729 and rs2241766, but not associated with rs1501299 (meta-analysis). PMID: 29807528
16. High ADIPOQ expression is associated with hypothyroidism. PMID: 28728192
17. adiponectin 45T/G polymorphism is associated with diabetic cardiovascular complication in type 2 diabetes PMID: 29686595
18. preoperative adiponectin levels correlate with postoperative complications after cancer surgery PMID: 29141566
19. women with gestational diabetes showed significantly low adiponectin and high resistin levels when compared with control group. PMID: 29207892
20. Late improvement of low-density lipoprotein cholesterol and adiponectin after transplant suggested that kidney transplant recipients may still have risk of cardiovascular events, especially in the first years. PMID: 27267514
21. Findings suggest a significant association between variants in COL13A1, ADIPOQ, SAMM50, and PNPLA3, and risk of NAFLD/elevated transaminase levels in Mexican adults with an admixed ancestry. PMID: 29307798
22. fetuin a to adiponectin ratio is more strongly associated with metabolic syndrome and its components than fetuin-A or adiponectin alone PMID: 28779425
23. component of mid-trimester amniotic fluid; its concentration varies with maternal body mass index and subsequent development of preterm birth, fetal growth restriction, and respiratory distress syndrome PMID: 28708576
24. Data suggest that first trimester measurement of adiponectin and 1,5-anhydroglucitol are potential early serum biomarkers for later onset of gestational diabetes; both serum levels are lower in women who later develop gestational diabetes than in women who do not. This study was conducted in Dublin, Ireland. PMID: 29328940
25. Worse nutritional state in de novo heart failure patients is associated with higher adiponectin plasma levels. Their levels were upregulated in adipose cells after being nutrients-starved. These results may help us to understand the adiponectin paradox in heart failure. PMID: 29559829
26. Adiponectin may be considered a biomarker of metabolic compensation, inversely associated with chronic low-grade inflammation. Circulating adiponectin is also associated with lower risk of adverse cardivascular events in patients with severe carotid stenosis. PMID: 29305337
27. Review/Meta-analysis: circulating adiponectin levels were significantly higher in patients with rheumatoid arthritis, but there was no correlation with disease activity. PMID: 28205390
28. ADIPOQ rs1501299 gene polymorphism is associated with an increased risk of new-onset diabetes mellitus after liver transplantation. PMID: 29291779
29. Serum levels of adiponectin were significantly and negatively associated with bone mineral density in patients with knee osteoarthritis. PMID: 29343264
30. Data suggest that higher consumption of bread and dairy products along with low intake of rice may be associated with increased serum adiponectin in Japanese women. PMID: 28637371
31. Data suggest that plasma adiponectin levels in obese women with low REE (resting energy expenditure) are significantly lower compared to obese women with low REE and compared to normal weight women. PMID: 29017362
32. Elevated plasma adiponectin concentrations were associated with both clinical and radiological disease severity in knee osteoarthritis patients. PMID: 26544540
33. High ADIPOQ expression is associated with osteoporosis and arterial stiffness. PMID: 28646476
34. Higher adiponectin levels were associated with a more favourable development of cardiovascular autonomic function in individuals with type 2 diabetes independently of multiple confounders. PMID: 29195493
35. Low ADIPOQ expression is associated with obesity. PMID: 28087246
36. Findings indicate that blood adiponectin concentration is more likely to be an epiphenomenon in the context of metabolic disease than a key determinant. PMID: 29237687
37. elevated circulating total adiponectin levels were associated with lower 10-year cardiovascular disease risk in adults without previous cardiovascular disease PMID: 29039145
38. in lumbar facet joint osteoarthritis, expression in the subchrondral bone decreased as the degeneration increased PMID: 29100514
39. Data suggest that transient increases in plasma adiponectin levels and transient decreases in plasma leptin levels occur following high-intensity interval exercise in overweight and obese young women. These studies were conducted in Turkey in formerly sedentary women ages 20-30 years. PMID: 28857629
40. Adipolin and adiponectin are cytokines that exert substantial impact on obesity, progression of atherosclerosis, insulin resistance, and glucose metabolism. PMID: 29452073
41. This meta-analysis demonstrates that serum/plasma levels of adiponectin in type 1 diabetes mellitus, rheumatoid arthritis, and systemic lupus erythematosus patients were higher than those in normal controls, but not in ankylosing spondylitis patients. PMID: 28702765
42. Data suggest that, in overweight and obese subjects, weight reduction induces changes in chemerin serum levels in parallel with adiponectin plasma levels; chemerin is down-regulated and adiponectin is up-regulated in both insulin-resistant and insulin-sensitive subjects after weight reduction; however, only changes in chemerin in insulin-sensitive subjects were found to be statistically significant. PMID: 28323510
43. ADIPOQ rs182052 AA allele is associated with obesity. PMID: 28947843
44. The current investigation demonstrated that, unlike the reduction in the levels of all the adiponectin isoforms and the high molecular weight (HMW) / total adiponectin (TA) ratio, an increased low molecular weight (LMW) / TA ratio was associated with T2D through its relation to insulin resistance. PMID: 29494595
45. This study showed that homeostatic model assessment (HOMA)-insulin resistance (IR) but not HOMA-adiponectin was appropriate for diagnosing IR. PMID: 29217381
46. Data suggest that vitamin D deficiency (indicated by low maternal 25(OH)D concentrations) in overweight/obese pregnant women at high-risk of gestational diabetes is associated with increased cardiometabolic risk during pregnancy and with adverse pregnancy outcomes; these associations may be mediated by HMW-adiponectin. PMID: 28741856
47. The depigmenting effect of adiponectin was mediated via AMPK activation, which induced the inhibitory phosphorylation of CREB-regulated transcription co-activators (CRTCs) and subsequent suppression of the novel CRTC/CREB pathway in melanocytes. PMID: 28481450
48. In anorexia nervosa subjects, TT genotype in ADIPOQ c.276 polymorphism was significantly more frequent than in control group. PMID: 28759190
49. Our data suggest that adiponectin and resistin are altered in non-obese chronic migraineurs. PMID: 27553954
50. An increased proportion of trunk fat is associated with decreased adiponectin in relatively overweight children, and also demonstrated that girls with a normal volume of body fat that follows a more centralized distribution show decreased adiponectin. PMID: 26655234
51. Low ADIP [adiponectin] and high CRP [C-reactive protein] are associated with excessive %BF [body fat percent] and FG[fasting glucose] in AA [African Americans] women. ADIP/CRP, may be useful for detecting metabolic dysregulation. PMID: 29026382
52. Adiponectin gene polymorphism (rs2241766) is a risk factor for type 2 diabetes mellitus in Iraqi population. The genotype distribution of rs2241766 SNP indicated a significant increase of carriers of the homozygous GG (OR: 5.04, CI95%: 2.27-11.19, P: 0.0001) and heterozygous TG (OR: 1.7, CI95%: 1.22-2.39, P: 0.002) variants . Results of rs822395 SNP failed to exhibit a significant difference PMID: 29627525
53. The GG genotype of ADIPOQ gene variant (rs1501299) is associated with an increase in adiponectin levels and a decrease of insulin and HOMA-IR after weight loss. PMID: 29325772
54. There was a direct association between the polymorphisms in LEP rs7799039 and ADIPOQ rs1501299 with overweight/obesity, and these genotypes affected the response to breast cancer chemotherapeutic treatment in Mexican women PMID: 28416193
55. 16 studies containing 4,113 MS cases and 3,637 healthy controls indicated a weak positive association between ADIPOQ +45 T>G polymorphism and the metabolic syndrome in the dominant genetic model, which was also validated by stratified subgroup analyses. There was a strong association with metabolic-related disease. Adiponectin level was not a causal factor of increasing stroke risk. PMID: 27578536
56. Genetic variation at the adiponectin gene, which influences adiponectin level, does not impact MS risk. PMID: 27903934
57. We enrolled 43 stable coronary artery disease (CAD) male patients to examine the relationship between cystatin C-adiponectin (CysC-APN) complex and coronary plaque characteristics. In multivariate analysis, CysC-APN complex levels were identified as the strongest negative factor for fibrotic components and the strongest positive factor for both necrotic and lipidic plus necrotic components. PMID: 28321013
58. High ADIPOQ expression is associated with ST-Segment Elevation Myocardial Infarction. PMID: 28100880
59. Polymorphisms in rs1501299 and rs2241766, and their additional interactions between rs1501299 and smoking were associated with increased CHD risks: polymorphism in rs7649121 was associated with decreased CHD risks. PMID: 28737466
60. data indicate that ADIPOQ rs266729 C>G polymorphism may contribute to the genetic risk of pre-diabetes and provide preliminary data useful in genetic screening for pre-diabetes among Thais. PMID: 29634196
61. these data uncover that ADIPOQ/adiponectin induces autophagic cell death in breast cancer and provide in vitro and in vivo evidence for the integral role of STK11/LKB1-AMPK-ULK1 axis in ADIPOQ/adiponectin-mediated cytotoxic autophagy. PMID: 28696138
62. Two polymorphisms, rs2241766 in ADIPOQ gene and rs10773989 in ADIPOR2 gene, especially under the recessive model of inheritance, played independent leading roles in susceptibility to myocardial infarction in Han Chinese. PMID: 29524572
63. Non-T allele of ADIPOQ gene variant (rs1501299) is associated with increases in adiponectin levels and better improvements of insulin and HOMA-IR after biliopancreatic diversion surgery massive weight loss in morbid obesity. PMID: 28601987
64. Severe, but not partial growth hormone deficiency impairs adiponectin production in the adipose tissue that is compensated by the increase of fat mass. PMID: 28650604
65. Data suggest that, among patients with type 2 diabetes plus recent acute coronary syndrome, those with highest baseline adiponectin plasma levels are at highest risk of death from a cardiovascular event. PMID: 28195387
66. Studied adiponectin (ADIPOQ), leptin (LEP), leptin receptor (LEPR), and resistin (RETN) single nucleotide polymorphisms and their association in obesity. Results showed that ADIPOQ 4522CPMID: 28195351
67. Results show that adiponectin, resistin and visfatin are present in osteophytes but have no direct influence on osteophyte development. Although these adipokines induce several inflammatory mediators, they do not affect osteoblast- or chondrocyte-related mechanisms of osteophyte development. PMID: 27884778
68. the association between adipokine levels and bone mineral density varies according to the menopause and central obesity status. PMID: 27873074
69. In patients with chronic kidney disease, serum adiponectin concentration significantly correlated with aortic stiffness. PMID: 27514393
70. This is the first study regarding the relationship of PPARGC1A and ADIPOQ polymorphisms, and the aggressiveness of prostate cancer in men with overweight or obesity. PMID: 28453464
71. the SNPs +45T>G (rs2241766), -4034A>C (rs822395), and -11391G>A (rs17300539) were linked to Coronary Artery Disease development; +276G>T (rs1501299) SNP was associated with a decreased susceptibility to Coronary Artery Disease among Caucasians (Meta-Analysis) PMID: 28617663
72. Dementia of neurodegenerative origin is characterized by elevated adiponectin levels. PMID: 28421328
73. Frequency of ADIPOQ -11377 risk allele is low and does not functionally affect the serum adiponectin levels; hence, ADIPOQ C-11377G SNPis not a risk factor for T2DM in Pakistani Punjabi Rajput patients. PMID: 29056124
74. results suggest weak associations between the studied variations in LEPR, RARRES2, and RETN genes and hand OA in Finnish women, and that the associations are modified by BMI PMID: 28812414
75. The IL-6 and adiponectin concentrations were not significantly different between the two groups PMID: 28534699
76. The development of type 2 Diabetes Mellitus in the Kyrgyz population is genetically determined by ADIPOQ (G276T) gene polymorphism with the predisposing value of the T allele of the heterozygous G276T genotype in the ADIPOQ gene. PMID: 29171469
77. Endurance training was associated with increased insulin sensitivity in adipose tissue as well as skeletal muscle without changes in circulating adiponectin young, normal-weight Japanese women. PMID: 28318384
78. analysis of naturally occurring mutations in ADIPOQ reveal insights into adiponectin biology including a possible compensatory mechanism to explain the clinically normal phenotype in G45R and R55C carriers who lack the HMW isoform PMID: 28643464
79. Recombinant human globular adiponectin suppressed lipopolysaccharide (LPS)-primed inflammasomes activation in murine peritoneal macrophages judged by prevention of interleukin-1beta (IL-1beta) maturation, caspase-1 activation, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) speck formation, and pyroptotic cell death. PMID: 28617316
80. During HCV infection, adiponectin affects insulin sensitivity through triglycerides and after viral clearance, adiponectin levels were directly associated with insulin sensitivity and decreased upon improved hepatic fibrosis. PMID: 28267407
81. The current knowledge on regulation and function of adiponectin in obesity, insulin resistance, and cardiovascular disease is summarized in this review. [review] PMID: 28635626
82. WZ4003 and SB203580 could suppress the APN-induced overexpression of CXCL1 and CXCL8. The results of the transwell chemotaxis assay also supported the above results. Our data suggest that APN can promote h-JBMMSC chemotaxis by up-regulating CXCL1 and CXCL8. PMID: 28176455
83. Cord blood adiponectin is a useful biomarker for the prediction of adiposity at the age of 5 y. Plasma HMW adiponectin levels do not predict body fat distribution between 3-5 y. PMID: 28052063
84. In a summary instrumental variable analysis (based on previously published data) with higher statistical power, no association between genetically determined twofold higher adiponectin and risk of colorectal cancer was observed (0.99, 95% CI 0.93, 1.06 in women and 0.94, 95% CI 0.88, 1.01 in men). Thus, our study does not support a causal effect of circulating adiponectin on colorectal cancer risk. PMID: 28550647
85. Adiponectin and pro-inflammatory cytokines are associated with type 2 diabetes mellitus, and might serve as a prognostic marker and a therapeutic intervention for overweight-related type 2 diabetes mellitus. PMID: 27684566
86. Decreased serum adiponectin levels were associated with risk factor for progression of pre-diabetes and type 2 diabetes in subjects. PMID: 28236525
87. Serum adiponectin levels are inversely associated with cardiorespiratory fitness in nonoverweight, but not in overweight adolescents. In nonoverweight adolescents, those with highest levels of cardiorespiratory fitness (above healthy zone) presented lower levels of adiponectin compared with those in under and healthy cardiorespiratory fitness zones. PMID: 27834578
88. Our results demonstrated that G allele of 211377C.G for adiponectin may be responsible for the decreased level of serum adiponectin which may apply as a potential index for the pathology for aneurysmal subarachnoid hemorrhage PMID: 26760913
89. Data suggest that, compared to non-diabetic subjects, adults with type 1 diabetes had significantly higher levels of circulating adiponectin. PMID: 27368123
90. the severity of metabolic syndrome exhibits long-term links to levels of insulin and adiponectin, suggesting potential genetic and environmental influences on insulin resistance over time PMID: 27133621
91. Review/Meta-analysis: genetic polymorphisms in leptin, adiponectin and their receptors affect the development and progression of prostate cancer. PMID: 27768592
92. The expression levels of adiponectin was significantly decreased in keloid fibroblasts. Adiponectin suppressed the CTGF-induced keloid fibroblast proliferation, migration and ECM production. PMID: 28498357
93. The G allele of rs266729 in adiponectin gene increases the risk of type 2 diabetes mellitus through an additive genetic model with an effect of 1.13 PMID: 29381968
94. Lower adiponectin levels together with higher blood pressure were independently associated with elevated carotid intima media thickness. Adiponectin concentration may be an independent marker of early structural damage in individuals at low-to-moderate cardiovascular risk. PMID: 27550907
95. CRT inhibition significantly blunted APN's anti-oxidative action (evidenced by gp91(phox) expression and superoxide generation). However, CRT inhibition did not attenuate AMPK phosphorylation by APN administration in NCM. Therefore, these novel findings strongly indicate that APN exerts cardioprotective effects against I/R injury partially via CRT mediated anti-apoptotic and anti-oxidative actions. PMID: 27757734
96. Lower plasma adiponectin levels were associated with major depressive disorder development in chronic hepatitis C patients. PMID: 27035148
97. serum concentration correlated with blood pressure in obese children and increased in response to lifestyle intervention PMID: 27882931
98. These findings are consistent with higher levels of serum leptin being associated with asthma regardless of age, and low adiponectin levels being associated with asthma in adults only. PMID: 27473714
99. Greater than twofold likelihood of a Metabolically Unhealthy profile among the T allele carries of the adiponectin T45 T polymorphism relative to the G allele carriers was found in adults with Abdominal Obesity. PMID: 28593612
100. To the best of our knowledge, the results showed that decreased adiponectin-mediated activity is associated with PTSD. Future studies are necessary to identify the causative role of adiponectin for PTSD as well as any possible covariates. PMID: 28662456

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HGNC: 13633

OMIM: 125853

KEGG: hsa:9370

STRING: 9606.ENSP00000320709

UniGene: Hs.80485