Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CXCL3 Polyclonal antibody

Uniprot No.

P19876

Target Names

CXCL3

Alternative Names

C-X-C motif chemokine 3 antibody; C-X-C motif chemokine ligand 3 antibody; Chemokine (C X C motif) ligand 3 antibody; Chemokine (CXC motif) ligand 3 antibody; Cinc 2 antibody; CINC 2b antibody; Cinc2 antibody; CINC2b antibody; CXCL 3 antibody; Cxcl3 antibody; CXCL3_HUMAN antibody; Cytokine induced neutrophil chemoattractant 2 antibody; Dcip1 antibody; Dendritic cell inflammatory protein 1 antibody; Gm1960 antibody; GRO protein gamma antibody; GRO-gamma antibody; GRO-gamma(1-73) antibody; GRO-gamma(5-73) antibody; GRO3 antibody; GRO3 oncogene antibody; GROG antibody; Growth regulated protein gamma antibody; Growth-regulated protein gamma antibody; Macrophage inflammatory protein 2 beta precursor antibody; Macrophage inflammatory protein 2-beta antibody; Melanoma growth stimulatory activity gamma antibody; Member 3 antibody; MGSA gamma antibody; MIP 2b antibody; MIP2-beta antibody; MIP2B antibody; SCYB3 antibody; Small inducible cytokine subfamily B antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human C-X-C motif chemokine 3 protein (35-107AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function	Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.
Gene References into Functions	CXCL3 exerts its carcinogenic potential by directly and/or indirectly regulating the downstream signaling pathways and the expression of transcription factors in PCa. PMID: 29524043 Exogenous CXCL3 induced Erk1/2 and ETS1 phosphorylation and promoted CD133 expression. PMID: 27255419 Our findings suggest that CXCL3 and its receptor CXCR2 are overexpressed in prostate cancer cells, prostate epithelial cells and prostate cancer tissues, which may play multiple roles in prostate cancer progression and metastasis. PMID: 26837773 results support a functional role of CXCL3 in breast cancer metastasis and as a viable target for cancer therapy PMID: 24605943 CXCL3 displays antimicrobial activity against E. coli and S. aureus. PMID: 12949249 secreted growth-regulated oncogene chemokines, specifically GRO-gamma, in human Mesenchymal stromal cell-conditioned media have an effect on the differentiation and the function of human monocyte-derived dendritic cells. PMID: 23589610 Data show that mesenchymal stem cells (MSCs) directly regulate T cell proliferation by induction of CXCL3 chemokine and its receptor, CXCR2 on the surface in T cells. PMID: 23023221 demonstrates, for the first time, that BIRC3 (anti-apoptotic protein), COL3A1 (matrix protein synthesis), and CXCL3 (chemokine) were up-regulated in the thrombin-stimulated human umbilical vein endothelial cells PMID: 16356540 GRO-gamma is a promising candidate for Th2-associated glomerular permeability factor in minimal change disease. PMID: 17389786 Inhibition of ERK phosphorylation decreased expression of GRO3. PMID: 17466952 Report gonadotropin-releasing hormone-regulated CXCL3 expression in human placentation. PMID: 19369450 propose that chemokines belonging to the CXC family could play an important role in the etiology of tendon xanthoma (TX), with CXCL3 being a possible biological marker of onset and development of TX PMID: 19448742 overexpression of CXCL13 in the intestine during inflammatory conditions favors mobilization of B cells and of LTi and NK cells with immunomodulatory and reparative functions. PMID: 19741597 Show More Hide All
Subcellular Location	Secreted
Protein Families	Intercrine alpha (chemokine CxC) family
Database Links	HGNC: 4604 OMIM: 139111 KEGG: hsa:2921 STRING: 9606.ENSP00000296026 UniGene: Hs.89690

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Check Code：

Code	CSB-PA08999A0Rb
Size	US$299Purchase it in Cusabio online store (only available for customers from the US)
Image	Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA08999A0Rb at dilution of 1:100
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CXCL3 Antibody

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