CXCL3 Antibody, FITC conjugated

Code CSB-PA08999C0Rb
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CXCL3 Polyclonal antibody
Uniprot No.
Target Names
CXCL3
Alternative Names
C-X-C motif chemokine 3 antibody; C-X-C motif chemokine ligand 3 antibody; Chemokine (C X C motif) ligand 3 antibody; Chemokine (CXC motif) ligand 3 antibody; Cinc 2 antibody; CINC 2b antibody; Cinc2 antibody; CINC2b antibody; CXCL 3 antibody; Cxcl3 antibody; CXCL3_HUMAN antibody; Cytokine induced neutrophil chemoattractant 2 antibody; Dcip1 antibody; Dendritic cell inflammatory protein 1 antibody; Gm1960 antibody; GRO protein gamma antibody; GRO-gamma antibody; GRO-gamma(1-73) antibody; GRO-gamma(5-73) antibody; GRO3 antibody; GRO3 oncogene antibody; GROG antibody; Growth regulated protein gamma antibody; Growth-regulated protein gamma antibody; Macrophage inflammatory protein 2 beta precursor antibody; Macrophage inflammatory protein 2-beta antibody; Melanoma growth stimulatory activity gamma antibody; Member 3 antibody; MGSA gamma antibody; MIP 2b antibody; MIP2-beta antibody; MIP2B antibody; SCYB3 antibody; Small inducible cytokine subfamily B antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human C-X-C motif chemokine 3 protein (35-107AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.
Gene References into Functions
  1. CXCL3 exerts its carcinogenic potential by directly and/or indirectly regulating the downstream signaling pathways and the expression of transcription factors in PCa. PMID: 29524043
  2. Exogenous CXCL3 induced Erk1/2 and ETS1 phosphorylation and promoted CD133 expression. PMID: 27255419
  3. Our findings suggest that CXCL3 and its receptor CXCR2 are overexpressed in prostate cancer cells, prostate epithelial cells and prostate cancer tissues, which may play multiple roles in prostate cancer progression and metastasis. PMID: 26837773
  4. results support a functional role of CXCL3 in breast cancer metastasis and as a viable target for cancer therapy PMID: 24605943
  5. CXCL3 displays antimicrobial activity against E. coli and S. aureus. PMID: 12949249
  6. secreted growth-regulated oncogene chemokines, specifically GRO-gamma, in human Mesenchymal stromal cell-conditioned media have an effect on the differentiation and the function of human monocyte-derived dendritic cells. PMID: 23589610
  7. Data show that mesenchymal stem cells (MSCs) directly regulate T cell proliferation by induction of CXCL3 chemokine and its receptor, CXCR2 on the surface in T cells. PMID: 23023221
  8. demonstrates, for the first time, that BIRC3 (anti-apoptotic protein), COL3A1 (matrix protein synthesis), and CXCL3 (chemokine) were up-regulated in the thrombin-stimulated human umbilical vein endothelial cells PMID: 16356540
  9. GRO-gamma is a promising candidate for Th2-associated glomerular permeability factor in minimal change disease. PMID: 17389786
  10. Inhibition of ERK phosphorylation decreased expression of GRO3. PMID: 17466952
  11. Report gonadotropin-releasing hormone-regulated CXCL3 expression in human placentation. PMID: 19369450
  12. propose that chemokines belonging to the CXC family could play an important role in the etiology of tendon xanthoma (TX), with CXCL3 being a possible biological marker of onset and development of TX PMID: 19448742
  13. overexpression of CXCL13 in the intestine during inflammatory conditions favors mobilization of B cells and of LTi and NK cells with immunomodulatory and reparative functions. PMID: 19741597

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Subcellular Location
Secreted.
Protein Families
Intercrine alpha (chemokine CxC) family
Database Links

HGNC: 4604

OMIM: 139111

KEGG: hsa:2921

STRING: 9606.ENSP00000296026

UniGene: Hs.89690

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