IL1B Antibody

Datasheet

Code	CSB-PA011614YA01SH
Size	US$166
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Image	Western blot All lanes: IL1B antibody at 2µg/ml + Recombinant Interleukin-1 beta protein 0.01µg Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 31 kDa Observed band size: 31 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Ovis aries (Sheep) IL1B Polyclonal antibody

Uniprot No.

P21621

Target Names

IL1B

Alternative Names

IL1BInterleukin-1 beta antibody; IL-1 beta antibody

Raised in

Rabbit

Species Reactivity

Sheep

Immunogen

Recombinant Sheep Interleukin-1 beta protein (114-266AA)

Immunogen Species

Ovis aries (Sheep)

Conjugate

Non-conjugated

The IL1B Antibody (Product code: CSB-PA011614YA01SH) is Non-conjugated. For IL1B Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA011614YB01SH	IL1B Antibody, HRP conjugated	ELISA
FITC	CSB-PA011614YC01SH	IL1B Antibody, FITC conjugated
Biotin	CSB-PA011614YD01SH	IL1B Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6.

Gene References into Functions

Intravenous injection of SB203580 successfully inhibited synthesis of IL-1beta and reduced the production of IL-6 in the hypothalamus. PMID: 24995301
Interleukin-1beta was increased only on the injured side of multifidus in disc disease. PMID: 24718080
Inactivation of RhoA due to lack of prenylation leads to Rac1 activation and subsequent priming for IL-1beta secretion. PMID: 25107911
RANTES-403 was significantly associated with the risk of developing diffuse-type gastric cancer in men and found a possible gene-gene interaction between RANTES and IL-1B polymorphisms in gastric cancer carcinogenesis. PMID: 24323564
In vitro studies with IL-1-beta and TNF-alpha challenges, both proinflammatory cytokines resulted in elevated levels of CCL5 in conditioned media (p<0.01) PMID: 24468005
These results showed that IL-1beta and IL-1 receptor types I and II were expressed in the ovine hypothalamus in response to lipopolysaccharide injection. PMID: 20345592
These data are consistent with the effects of LPS on GH secretion originating through peripheral cytokine presentation to the pituitary, as well as a potential to act directly on selective populations of pituitary cells via CD14. PMID: 15899940
plasma IL-1 beta, TNF-alpha and MCP-1 may potentially serve as markers to monitor prognosis of pregnancy toxaemia in ewes PMID: 17221363

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Subcellular Location

Cytoplasm, cytosol. Lysosome. Secreted, extracellular exosome. Secreted.

Protein Families

IL-1 family

Database Links

KEGG: oas:443539

UniGene: Oar.434

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Related pathways

MAPK signaling pathway Lipids and Inflammation in Atherogenesis NF-kappa B signaling pathway TNF signaling pathway Necroptosis Hematopoietic cell lineage IL-17 signaling pathway Inflammasome Signaling NOD-like receptor signaling pathway Osteoclast differentiation Th17 cell differentiation Toll-like receptor signaling pathway AGE-RAGE signaling pathway in diabetic complications Excitatory synapse pathway

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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