MUC16 Antibody

Code CSB-PA10657A0Rb
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
  • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA10657A0Rb at dilution of 1:20

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA10657A0Rb at dilution of 1:20

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) MUC16 Polyclonal antibody
Uniprot No. Q8WXI7
Target Names MUC16
Alternative Names CA 125 antibody; CA-125 antibody; CA125 antibody; CA125 ovarian cancer antigen antibody; Cancer antigen 125 antibody; FLJ14303 antibody; MUC 16 antibody; MUC-16 antibody; MUC16 antibody; MUC16_HUMAN antibody; Mucin 16 antibody; Mucin 16 cell surface associated antibody; Mucin-16 antibody; Mucin16 antibody; Ovarian cancer related tumor marker CA125 antibody; Ovarian cancer-related tumor marker CA125 antibody; Ovarian carcinoma antigen CA125 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Mucin-16 protein (21712-21973AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:10-1:100
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
Gene References into Functions
  1. Studied levels of mucin 16 (CA125), adenosine deaminase and midkine as tumor markers in nonsmall cell lung cancer-associated malignant pleural effusion. PMID: 29797475
  2. The expression profile of studied Mucins MUC16 and MUC1 and truncated O-glycans was not associated with the site of origin of ovarian cancer (OVCA) cell lines PMID: 30011875
  3. Serum HE4 with its high specificity is useful in ruling out ovarian malignancy especially among the premenopausal women and Risk of Ovarian Malignancy Algorithm (ROMA)which is the combination of both serum CA 125 and HE4, appears to be an all-rounder with overall good sensitivity and specificity especially among the postmenopausal women. PMID: 30063463
  4. CA125 appears the most reliable biomarker for OC monitoring, whereas HE4 contributes additional information only in a minority of cases PMID: 30125544
  5. The level of HE4 in ovarian cancer ascites may reflect the therapeutic effect of ovarian cancer patients, and a high level of HE4 might predict chemoresistance and the possibility of ascites formation. The determination of the expression of HE4 alone or combined with CA125 levels in both serum and ascites in ovarian cancer patients with ascites may have important significance for guiding and improving the treatment PMID: 29903044
  6. Lower CA125 serum levels, negative vascular invasion, and wild-type BRAF status were significantly associated with improved 2-year DFS rates among patient with stage III disease who received adjuvant chemotherapy. PMID: 29562502
  7. We can infer from this study that increased maternal serum CA 125 levels are associated with the preeclampsia and its severity. PMID: 29718786
  8. Serum CA125 concentrations are correlated with coronary artery calcification score in the population without known coronary artery disease. PMID: 29731508
  9. High serum CA125 level is associated with epithelial ovarian cancer. PMID: 28444641
  10. Serum CA-125 was significantly different between infertile women with and without pelvic endometriosis. PMID: 29944231
  11. Use of HE4 instead of CA125 did not significantly improve diagnostic performance of risk of malignancy indices 1-4 in patients with an adnexal mass PMID: 29238719
  12. TP53 autoantibody levels provide a biomarker with clinically significant lead time over elevation of CA125 or an elevated ROCA value. Quantitative assessment of autoantibodies in combination with CA125 holds promise for earlier detection of invasive epithelial ovarian cancer PMID: 28637689
  13. CA-125 levels may be the most useful marker for predicting advanced-stage disease PMID: 25761476
  14. For screened women at familial/genetic ovarian cancer risk, risk of ovarian cancer algorithm had better early-stage sensitivity at high specificity, and low yet possibly acceptable positive predictive value compared with CA125 , warranting further larger cohort evaluation. PMID: 28143870
  15. Serum SCC-Ag, hs-CRP, and CA-125 were higher in recurrence cervical patients which could be potential biomarkers for predicting cervical cancer recurrence risk. PMID: 28901315
  16. The determination of CA125 before surgery may be helpful in the evaluation of the regional lymph nodes, and is a poor prognostic factor for overall survival and disease-free survival in endometrial cancer. PMID: 28624692
  17. High CA125 expression is associated with adnexal malignancy. PMID: 27116243
  18. The ratio between menstrual and midcycle phases had the worst performance. CA-125 may be useful for the diagnosis of deep endometriosis, especially when both are collected during menstruation and in midcycle. PMID: 28660213
  19. Architect CA 125 II and HE4 values in Chinese women presenting with a pelvic mass PMID: 28549533
  20. highly predictive of endometriosis in women with symptoms of pain and/or subfertility PMID: 27987404
  21. HE4 seems to be superior to CA125 in the detection of recurrent disease. PMID: 29463191
  22. High CA125 expression is associated with breast, endometrial and ovarian cancers. PMID: 26918940
  23. knockdown of MUC16 significantly weakened the capabilities of cells for proliferation and migration PMID: 27167110
  24. In this platinum-resistant population, PD was typically detected earlier by imaging than by CA-125, irrespective of bevacizumab treatment. Disease status by CA-125 at the time of PD was not prognostic for overall survival. Regular radiologic assessment as well as symptom benefit assessment should be considered during PROC follow-up. PMID: 27407100
  25. Data characterized CA-125 kinetics and identified modeled kinetic parameters. PMID: 29187468
  26. these studies demonstrate that PPARgamma is an important modulator of MUC16 expression. PMID: 27292441
  27. These data point to a novel opportunity to enrich Abs at mucosal sites by targeting Abs to MUC16 through changes in Fc glycosylation, potentially blocking viral movement and sequestering the virus far from the epithelial border. PMID: 26960182
  28. Within this review, we highlight both the processes involved in the expression of aberrant glycan structures on mucins, as well as the potential downstream impacts on cellular signaling. PMID: 27483328
  29. In a cohort of patients with acute decompensated heart failure, cancer antigen 125 is independently associated with prolonged length of stay. PMID: 28265209
  30. The current study uncovers the contribution of oncogenic KRAS to serum marker CA125 production through a mechanism that involves the ERK/c-Myc axis. PMID: 28108627
  31. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. PMID: 28287406
  32. the loss of MUC16 and E-cadherin expression resulted in the formation of more compact spheroids. In addition, our data describe an unusual link between E-cadherin expression and less compact spheroids. Our data also emphasize the role of MUC16 and b1 integrin in Epithelial ovarian cancer (EOC) spheroid formation. PMID: 27612856
  33. Preoperative CA-125 can predict neither the progression-free nor overall survival for primary serous ovarian cancer patients. PMID: 28551658
  34. In pseudomyxoma peritonei CA125 was infrequently expressed by tumor cells, but in most of the cases adjacent nonneoplastic mesothelial cells. PMID: 27038681
  35. Differences in the apparent expression levels of CEA, CA153 and CA125 in patients with nipple discharge and healthy persons were validated. PMID: 27327081
  36. The endometrial expression of PR and Ki67 along with serum CA125 predicted the development of lymph node metastasis in endometrial cancer. PMID: 27163153
  37. a distinct role for N-glycans in promoting MUC16's binding affinity toward galectin-3 and in causing retention of the lectin on the epithelial cell surface. PMID: 28487369
  38. HE4 is elevated less frequently than CA125 in benign adnexal tumors, regardless of age or menopausal status PMID: 27752776
  39. rebamipide induces the differential upregulation of MUC16 in stratified cultures of human corneal epithelial cells, which may have implications to the proper restoration of barrier function in ocular surface disease. PMID: 27725198
  40. In postmenopausal women, CA-125 levels were significantly higher in those with epithelial ovarian cancer. PMID: 27855043
  41. When the value of CA125 is higher than 10 U/ml and continuously increased, need to be vigilant and should be combined with imaging examination (PET-CT), early detection of recurrent lesions and early retreatment, especially maybe have the opportunity for surgery, this result may improve the prognosis for recurrent patients. PMID: 28284216
  42. Pap test abnormalities are frequent in ECCC. Although it is less accurate in the diagnosis of ECCC than in the detection of malignancy, endometrial sampling is still the main procedure for the diagnosis of ECCC. Higher preoperative CA-125 concentrations imply the presence of advanced stage ECCC. PMID: 27173475
  43. levels before treatment and decreased speed of decline of serum CA125 after treatment were independent factors. There is a negative correlation between pre-treatment CA125 level and prognosis, the sooner decrease of CA125 levels post-treatment the better prognosis are. PMID: 27629537
  44. We found the high specificity of HE4 and CA125 while differentiating ovarian benign diseases from epithelial ovarian cancer in postmenopausal women and the high sensitivity of CA125 in detecting epithelial ovarian cancer in premenopausal patients PMID: 27436085
  45. Results collectively indicate unique links between dual-specificity phosphatase 28 (DUSP28) and mucins MUC5B/MUC16 and their roles in pancreatic cancer. PMID: 27230679
  46. that, in adenocarcinomas and borderline ovarian tumors, the major carriers of SLe(a) and SLe(x) are MUC16 and/or MUC1 (100 and 92 % for SLe(a) PMID: 27003157
  47. A statistically significant difference was observed between HE4 values at primary diagnosis and at recurrence, respectively, comparing recurrent and non-recurrent patients while CA125 values resulted not statistically significant at each time point. PMID: 26531723
  48. We assessed the diagnostic accuracy of a newly developed laboratory score-based on CA125, platelet count (PLT), C-reactive protein (CRP), and fibrinogen levels-in the preoperative diagnosis of adnexal mass PMID: 26499778
  49. High CA125 expression is associated with Ovarian Tumors. PMID: 27268637
  50. We evaluated the clinical performance of LOCItrade mark-based tumor marker assays CEA, CA19-9, CA15-3, CA125 and AFP in patients with gastrointestinal cancer and demonstrated their high diagnostic power PMID: 28011514
  51. High CA-125 levels are associated with Myometrial Invasion in Patients with Early-stage Endometrioid- type Endometrial Cancer. PMID: 26925634
  52. High Serum Levels of CA 125 is associated with Epithelial Ovarian Cancer. PMID: 27221870
  53. Serum CA 12-5 level and TNM status predict the long-term prognosis of resected primary adenosquamous carcinoma of the lung. PMID: 27002010
  54. Diagnostic values of serum CA125 combined with osteopontin for ovarian cancer [meta-analysis] PMID: 26458935
  55. CEA, NSE, CA125 and pro-GRP could serve as biomarkers for SCLC, and CEA and CYFRA21-1 could serve as biomarkers for NSCLC. Pro-GRP, CA125 and CEA were related to the clinical stages of lung cancer PMID: 26560853
  56. optimal cut-off values (HE4: 70pmol/l for all; CA125: 60U/ml for pre- and 35U/ml for postmenopausal women) could notably improve diagnostic performance in EOC detection in patients in southern China PMID: 26285075
  57. increased gene expression of MUC16 and MUC20 was found in patients with remission ulcerative colitis PMID: 26770020
  58. Data suggest that dual inhibition of vascular endothelial growth factor (VEGF) and CA125 protein might bring about a better outcome for patients with epithelial ovarian cancer (EOC). PMID: 26143638
  59. Data show that both mucin16 (MUC16) and podocalyxin (PODXL)-E-selectin-mediated interactions are mechanically stronger than like L-selectin interactions at the single-molecule level. PMID: 26329844
  60. Results demonstrate that MUC16 plays an important role in metabolic reprogramming of pancreatic cancer cells by increasing glycolysis and enhancing motility and invasiveness. PMID: 26046375
  61. the diagnostic value of serum cancer antigen (CA)125, CA19-9 and CA15-3 concentrations in endometriosis, was evaluated. PMID: 26246541
  62. Elevated CA125 seems to be associated with the presence of peritoneal implants of any type at initial diagnosis of serous Borderline Tumors of the Ovary. PMID: 25978292
  63. MAMs MUC1 and MUC16 contribute to the maintenance of immune homeostasis at the ocular surface by limiting TLR-mediated innate immune responses. PMID: 25563498
  64. Elevation of serum CA125 is associated with Non-small Cell Lung Cancer. PMID: 26163610
  65. An increased preoperative CA125 level is an independent predictor of worse clinical outcomes after off pump coronary artery bypass grafting during a 1-year follow-up. PMID: 25968305
  66. Serum CA125 levels that remain elevated after CHD onset could be helpful for predicting the short-term risk of heart failure events in CHD patients. PMID: 24831034
  67. The CA125, HE4, and ROMA values differed significantly depending on the presence of peritoneal dissemination (p < 0.0001). PMID: 26045023
  68. Data found LRG1 as a promising candidate marker for detection of epithelial ovarian cancer (EOC) and the combination of LRG1 and CA125 showed improved performance to distinguish EOC including early stage EOC from non-cases compared to CA125. PMID: 25799488
  69. MUC16-Cter mediated enrichment of CSCs is partly responsible for tumorigenic, metastatic and drug-resistant properties of pancreatic cancer cells. PMID: 25691062
  70. IL-6 was found to be strongly associated with advanced serous EOC and could be used in combination with serum CA125 to discriminate benign and epithelial ovarian carcinoma PMID: 26122176
  71. The measurement of the CA 19-9 antigen on individual proteins could improve performance over the standard CA 19-9 assay. PMID: 22220206
  72. the combination of RECAF and CA125 serum values provides the specificity and the sensitivity necessary to screen for ovarian cancer[RECAF] PMID: 21625941
  73. Integrating the dual-signal amplification strategy, a novel 3D origami electrochemical immunodevice for simultaneous detecting carcinoembryonic antigen (CEA) and cancer antigen 125 (CA125) PMID: 25048447
  74. Results show that the carboxy-terminal portion of the MUC16 protein is oncogenic in NIH/3T3 cells, increases invasive tumor properties, activates the AKT and ERK pathways, and contributes to the biologic properties of ovarian cancer. PMID: 25965947
  75. Significant differences were shown between endometrioma versus teratoma groups for fibrinogen level (3.12 mg% vs. 2.57 mg%; p = 0.001) and CA-125 (36.50 U/mL vs. 15.08 U/mL; p = 0.001). PMID: 25951715
  76. Benign leiomyoma accompanied by pseudo-Meigs' syndrome and elevated serum CA125 can mimic a pelvic malignancy PMID: 25891047
  77. In patients with acute heart failure, Gal-3 was strongly associated with higher risk of long-term mortality and repeated rehospitalizations, but only in those patients exhibiting higher values of CA125 (above 67 U/ml). PMID: 25875367
  78. CA-125 level is associated with the development of AF in patients with hospitalized systolic HF. PMID: 25256054
  79. High expression of CA125 was found in patients with endometriosis that was curative with laparoscopy. PMID: 25967705
  80. proteolytic clearing of MUC16/CA-125, catalyzed by MT1-MMP, may then expose integrins for high-affinity cell binding to peritoneal tissues PMID: 25205731
  81. The significant difference was observed in patients with endometriosis/endometriomas in which HE4 was not elevated patients and CA125 was elevated in 53% (P<0.001). PMID: 25834501
  82. In the differential diagnosis of adenomyosis and myoma, cut-off values for CA125, particularly the cut-off value of 19 U/mL, provide improved diagnostic performance. PMID: 25577553
  83. Detection of glyco-mucin profiles improves specificity of MUC16 and MUC1 biomarkers in ovarian serous tumours. PMID: 25454345
  84. The combined detection of CYFRA21-1, CA125, SCC and CA153 is an effective way to distinguish benign and malignant SPN, and will find an important clinical application in the early diagnosis of SPN. PMID: 25531720
  85. Suggest preoperative serum level of CA19-1 may be more useful than CEA, CA72-4, AFP and CA125 levels as a prognostic factor in gastric cancer. PMID: 26176088
  86. A combined CEA and CA 125 approach may help segregate mucinous cystic neoplasms from intraductal papillary mucinous neoplasms PMID: 25458668
  87. High serum CA19-9 and CA125 is associated with cystic teratoma of the ovary. PMID: 25416055
  88. The elevation of CA125 before treatment predicts a poor prognosis in patients with multiple brain metastases from non-small cell lung cancer before and after treatment of whole-brain radiotherapy. PMID: 24913812
  89. High levels of neuron-specific enolase (NSE), carbohydrate antigen 125 (CA125) and squamous cell carcinoma antigen (SCC) were detected in 306 (63.6%), 89 (18.5%) and 125 (26.0%) non-small cell lung cancer patients, respectively. PMID: 23712355
  90. Elevated serum CA125 in patients with metastatic or recurrent gastric cancer was an independent negative predictor of prognosis. PMID: 25344872
  91. Immunohistochemical distinction of renal cell carcinoma from other carcinomas with clear-cell histomorphology: utility of CD10 and CA-125 in addition to PAX-2, PAX-8, RCCma, and adipophilin. PMID: 25279712
  92. Combinational analysis of CA125 with Trx1 for the detection of ovarian cancer suggests that the diagnostic capacity of CA125 alone for the early detection of ovarian cancer is significantly improved by its combination with Trx1. PMID: 25174623
  93. Measurement of combined HE4 and CA125 levels provides a more accurate method for epithelial ovarian cancer diagnosis. PMID: 25326813
  94. Both the serum CA125(meso) level and the ratio of the serum CA125(meso) to CA125 levels (CA125(meso) /CA125) were significantly higher in patients with EOC. PMID: 25197000
  95. MUC1, MUC4, and MUC16 expression does not vary significantly in normal endometrium during the menstrual cycle or in endometriosis relative to the epithelial marker, cytokeratin-18 (KRT18). PMID: 24939955
  96. An association between strong claudin-5 expression and higher serum levels of TATI (p=0.04) and CA125 (p=0.008) were found PMID: 25667483
  97. No prognostic benefit was found in measuring effuent CA125 in peritoneal dialysis patients with acute peritonitis. PMID: 25217152
  98. Serum HE4 and CA125 as predictors of response and outcome during neoadjuvant chemotherapy of advanced high-grade serous ovarian cancer. PMID: 25190018
  99. Disrupting the binding of miR-125b toward BMPR1B would increase protein expression, diminishing abnormal cell proliferation as well as serum and cellular CA125 levels PMID: 24339876
  100. role of MUC1 and MUC16 in epithelial barrier function PMID: 24968021

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Subcellular Location Cell membrane, Single-pass type I membrane protein, Secreted, extracellular space
Tissue Specificity Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas.
Database Links

HGNC: 15582

OMIM: 606154

KEGG: hsa:94025

STRING: 9606.ENSP00000381008

UniGene: Hs.432676

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