PLCG2 (Ab-1217) Antibody

Code CSB-PA834542
Size US$297 How to order?
  • Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using PLC-g2(Ab-1217) Antibody(left) or the same antibody preincubated with blocking peptide(right).
  • Immunofluorescence staining of methanol-fixed Hela cells using PLC-g2(Ab-1217) Antibody.
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) PLCG2 Polyclonal antibody
Uniprot No. P16885
Target Names PLCG2
Alternative Names 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 2 antibody; 1-phosphatidylinositol-4 antibody; 5-bisphosphate phosphodiesterase gamma-2 antibody; EC antibody; Phosphoinositide phospholipase C antibody; Phosphoinositide phospholipase C-gamma-2 antibody; Phospholipase C gamma 2 antibody; Phospholipase C, gamma 2 (phosphatidylinositol specific) antibody; Phospholipase C-gamma-2 antibody; Phospholipase C-IV antibody; PLC 2 antibody; PLC gamma 2 antibody; PLC IV antibody; PLC-gamma-2 antibody; PLC-IV antibody; Plcg2 antibody; PLCG2_HUMAN antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Peptide sequence around aa.1215~1219 (F-L-Y-D-T) derived from Human PLCg2.
Immunogen Species Homo sapiens (Human)
Clonality Polyclonal
Purification Method Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration It differs from different batches. Please contact us to confirm it.
Form Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications ELISA,IHC,IF
Recommended Dilution
Application Recommended Dilution
IHC 1:50-1:100
IF 1:100-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
Gene References into Functions
  1. finding that mutations or polymorphisms in two putative calcium-regulated domains of PLCG2 are associated with ibrutinib-resistant CLL adds to the evidence supporting complex regulatory shifts in the PLCG2 protein likely occurring during the development of resistance PMID: 28366935
  2. The results suggest a new mechanism of PLCgamma activation with unique thermodynamic features and assign a novel regulatory role to its spPH domain. PMID: 27196803
  3. Data show that protein-altering changes are in PLCG2, ABI3, and TREM2 genes highly expressed in microglia and highlight an immune-related protein-protein interaction network in Alzheimer's disease. PMID: 28714976
  4. Ocular manifestations of phospholipase-Cgamma2-associated antibody deficiency and immune dysregulation show mutations in the PLC[gamma]2 gene leading to aberrant function of immune cells and overproduction of interleukin-1 [beta] (IL-1[beta]). PMID: 27442322
  5. R665W and L845F be referred to as allomorphic rather than hypermorphic mutations of PLCG2 Rerouting of the transmembrane signals emanating from BCR and converging on PLCgamma2 through Rac in ibrutinib-resistant CLL cells may provide novel drug treatment strategies to overcome ibrutinib resistance mediated by PLCG2 mutations or to prevent its development in ibrutinib-treated CLL patients. PMID: 27542411
  6. Data show that phospholipase Cgamma2 (PLCgamma2) is strongly expressed in B cell non-Hodgkin lymphoma and especially in a large subset of Diffuse large B-cell lymphoma (DLBCL). PMID: 25012946
  7. Characterization of the effect of missense point-mutation at R665W in PLCG2 on signaling mechanisms of ibrutinib resistance in chronic lymphocytic leukemia cells. PMID: 25972157
  8. amarogentin prevents platelet activation through the inhibition of PLC gamma2-PKC cascade and MAPK pathway PMID: 24868545
  9. PLCG2 missense mutation is a risk factor in the development of steroid sensitive nephrotic syndrome in childhood. PMID: 25349203
  10. The autoinhibitory C-terminal SH2 domain of phospholipase C-gamma2 stabilizes B cell receptor signalosome assembly. PMID: 25227611
  11. The relationship between upstream tyrosine kinase SYK and its target, PLCgamma2, is maximally predictive and sufficient to distinguish chronic lymphocytic leukemia from healthy controls. PMID: 24489640
  12. Single-nucleotide polymorphisms in PLCG2 gene is associated with breast cancer risk after menopausal hormone replacement therapy. PMID: 24080446
  13. identified three distinct mutations in PLCgamma2 in two patients resistant to ibrutinib PMID: 24869598
  14. early Ca(2+) fluxing provides feed-forward signal amplification by promoting anchoring of the PLCgamma2 C2 domain to phospho-SLP65. PMID: 24166973
  15. BANK1 and BLK have roles in B-cell signaling through phospholipase C gamma 2 PMID: 23555801
  16. down-regulation of PLCgamma2-beta-catenin pathway occurs in mice and humans and leads to myeloid-derived suppressor cells-mediated tumor expansion. PMID: 24127488
  17. Associations between treatment response and Lyn, Syk, PLCgamma2 and ERK were not found. PMID: 23039362
  18. Overexpression of the altered p.Ser707Tyr protein and ex vivo experiments using affected individuals' leukocytes showed clearly enhanced PLCgamma2 activity. PMID: 23000145
  19. PLCgamma2 participates in T cell receptor (TCR) signal transduction and plays a role in T cell selection in a transgenic mouse model. PMID: 22837484
  20. Genomic deletions in PLCG2 cause gain of PLCgamma(2) function, leading to signaling abnormalities in multiple leukocyte subsets and a phenotype encompassing both excessive and deficient immune function. PMID: 22236196
  21. Data indicate a role for PLCgamma2 and Ca(2+) signaling through the modulation of MEK/ERK in IL3/GM-csf stimulated human hematopoietic stem/progenitor cells. PMID: 21506110
  22. Rac2 binding in the absence of lipid surfaces was not able to activate phospholipase C gamma 2. PMID: 21245382
  23. SYK, together with phospholipase Cgamma2, may serve as potential biomarkers to predict dasatinib therapeutic response in patients. PMID: 20068106
  24. Data show that bile acid reflux present in patients with BE may increase reactive oxygen species production and cell proliferation via activation of PI-PLCgamma2, ERK2 MAP kinase, and NADPH oxidase NOX5-S, thereby contributing to the development of EA. PMID: 20086178
  25. Data show that RTX treatment results in a time-dependent inhibition of the BCR-signaling cascade involving Lyn, Syk, PLC gamma 2, Akt, and ERK, and calcium mobilization. PMID: 19965664
  26. collagen receptor glycoprotein VI and alphaIIbbeta3 trigger distinct patterns of receptor signalling in platelets, leading to tyrosine phosphorylation of PLCgamma2 (integrin alphaiibbeta3) PMID: 12049640
  27. Two tyrosine residues in regulating the activity of PLCgamma2 PMID: 12181444
  28. full-length cDNA for human PLCgamma2 and expressed it in E. coli using the expression vector pT5T PMID: 12359094
  29. PLCG2 has a signaling role in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization PMID: 12813055
  30. in gastric cancer, protein translocation of PLCgamma2 and PKCalpha is critical event in the process of apoptosis induction. PMID: 14606067
  31. PLC-gamma2 is phosphorylated on Y753, Y759, and Y1217 in response to engagement of the B-cell receptor PMID: 15509800
  32. The PLCgamma2 is present in the majority of mediastinal B cell lymphomas. PMID: 15744341
  33. novel mechanism of PLCgamma(2) activation by Rac GTPases involving neither protein tyrosine phosphorylation nor PI3K-mediated generation of PtdInsP(3) PMID: 16172125
  34. intracellular mediators and pathways activated by leptin downstream of JAK2 were found to include phosphatidylinositol-3 kinase, phospholipase Cgamma2 and protein kinase C, as well as the p38 MAP kinase-phospholipase A(2) axis. PMID: 18000612
  35. Plasmacytoid dendritic cells express a signalosome consisting of Lyn, Syk, Btk, Slp65 (Blnk) and PLCgamma2. Triggering CD303 leads to tyrosine phosphorylation of Syk, Slp65, PLCgamma2 & cytoskeletal proteins. PMID: 18022864
  36. rac regulates its effector phospholipase Cgamma2 through interaction with a split pleckstrin homology domain PMID: 18728011

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Involvement in disease Familial cold autoinflammatory syndrome 3 (FCAS3); Autoinflammation, antibody deficiency, and immune dysregulation PLCG2-associated (APLAID)
Database Links

HGNC: 9066

OMIM: 600220

KEGG: hsa:5336

STRING: 9606.ENSP00000352336

UniGene: Hs.372303

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