Phospho-CLDN6 (Tyr219) Antibody

Datasheet
Code CSB-PA207788
Product Type Polyclonal Antibody
Former Code(s) CSB-PA785527
Size US$360
Uniprot No. P56747
Image
  • Western blot analysis of extracts from RAW264.7 cells treated with UV using Claudin 6 (Phospho-Tyr219) Antibody.The lane on the right is treated with the antigen-specific peptide.
Immunogen Peptide sequence around phosphorylation site of tyrosine 219 (T-K-N-Y(p)-V) derived from Human Claudin 6.
Raised in Rabbit
Species Reactivity Human,Mouse
Specificity The antibody detects endogenous levels of Claudin 6 only when phosphorylated at tyrosine 219.
Tested Applications ELISA,WB;WB:1:500-1:1000
Relevance

Claudin 6 Plays a major role in tight junction-specific obliteration of the intercellular space. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO- 3.

Keen T.J., Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Troy T., Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
Clark H.F., Genome Res. 13:2265-2270(2003).

Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Clonality Polyclonal
Alias claudin 6; claudin-6; CLD6; Skullin 2;
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Target Names CLDN6
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Plays a major role in tight junction-specific obliteration of the intercellular space.
Subcellular Location Cell junction, tight junction, Cell membrane, Multi-pass membrane protein
Protein Families Claudin family
Tissue Specificity Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.
Database Links

HGNC: 2048

OMIM: 615798

KEGG: hsa:9074

STRING: 9606.ENSP00000328674

UniGene: Hs.533779

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