CLDN6 is located on chromosome 16p3.3 and has a molecular weight of about 20-40 kDa. The claudins have similar structures to each other, having four transmembrane structural domains, two extracellular loops, and two intracellular tail regions. CLDN6 possesses a C-terminal PDZ binding site allows tight junction proteins to interact with certain intracellular proteins, which is essential in cell junctions and epithelial tissue permeability
More and more studies have shown that abnormal expression of CLDN6 can participate in the occurrence and development of breast cancer, ovarian cancer, cervical cancer, gastric cancer, lung cancer, and other malignant tumors. CLDN6, as an important molecule in the formation of the cytoskeleton and the regulation of cell signaling pathways, can affect the growth process of cells, which provides a new direction for the diagnosis and intervention of tumors. At present, a variety of drugs targeting CLDN6 are in the clinical and preclinical stages and are used for the treatment of many tumors.
Recombinant Human Claudin-6(CLDN6)-VLPs (Active) (CSB-MP005508HU(A4))
Validated Data
The specifity was validated by western blot. CSB-MP005508HU(A4) is detected by Mouse anti-6*His monoclonal antibody.
Immobilized Human CLDN6 at 10 μg/ml can bind Anti-CLDN6/9 recombinant antibody (CSB-RA005508MA1HU), the EC50 is 1.501-2.035 ng/mL
The presence of VLP-like structures was confirmed by TEM
The following CLDN6 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CLDN6 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA207788 | Phospho-CLDN6 (Tyr219) Antibody |
Human,Mouse | ELISA,WB |
CSB-PA263732 | CLDN6 Antibody |
Human | ELISA,WB,IHC,IF |
CSB-PA001673 | CLDN6 Antibody |
Human | WB, IHC, IF, ELISA |
CSB-PA070220 | Phospho-CLDN6 (Y219) Antibody |
Human,Mouse | WB, IHC, ELISA |
CSB-PA070221 | CLDN6 Antibody |
Human,Mouse | IHC, ELISA |
CSB-PA005508LA01HU | CLDN6 Antibody |
Human | ELISA, IHC, IF |
CSB-PA005508LB01HU | CLDN6 Antibody, HRP conjugated |
Human | ELISA |
CSB-RA005508MA1HU | CLDN6/9 Monoclonal Antibody |
Human | ELISA,FC |
CLDN6 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF005508HU | Recombinant Human Claudin-6(CLDN6),partial |
in vitro E.coli expression system |
CSB-YP005508HU1 CSB-EP005508HU1 CSB-BP005508HU1 CSB-MP005508HU1 CSB-EP005508HU1-B |
Recombinant Human Claudin-6(CLDN6),partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-MP005508HU(A4) | Recombinant Human Claudin-6(CLDN6)-VLPs (Active) |
Mammalian cell |