SAE1 Antibody

Datasheet

Code	CSB-PA794022
Size	US$297
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Image	Immunofluorescence analysis of HuvEc cells, using AOS1 antibody. Western blot analysis of extracts from 293 cells, using AOS1 antibody. Western blot analysis of extracts from Colo cells, HepG2 cells and 293 cells using AOS1 antibody. The lane on the left is treated with synthesized peptide.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SAE1 Polyclonal antibody

Uniprot No.

Q9UBE0

Target Names

SAE1

Alternative Names

Activator of SUMO1 antibody; AOS1 antibody; HSPC140 antibody; Sae1 antibody; SAE1_HUMAN antibody; Sentrin/SUMO activating protein AOS1 antibody; SUA1 antibody; SUMO 1 activating enzyme E1 N subunit antibody; SUMO 1 activating enzyme subunit 1 antibody; SUMO-activating enzyme subunit 1 antibody; Ubiquitin like protein SUMO1 activating enzyme antibody; Ubiquitin-like 1-activating enzyme E1A antibody; UBL E1A antibody; UBLE1A antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from Internal of Human AOS1.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB,IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000
IF	1:100-1:500

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

Gene References into Functions

the expression of SENP8, SAE1, PIAS1, PIAS2 and ZMIZ1 is deregulated in the majority of PTC tissues, likely contributing to the PTC phenotype. PMID: 26403403
as it has been shown by flow cytometry analysis, specific knockdown of SAE1 slowed down the cell population at G0/G1 phase and induced apoptosis of RKO cells. PMID: 25842831
SUMO-1 controls the protein stability and the biological function of phosducin. PMID: 16421094

Subcellular Location

Nucleus.

Protein Families

Ubiquitin-activating E1 family

Tissue Specificity

Expression level increases during S phase and drops in G2 phase (at protein level).

Database Links

HGNC: 30660

OMIM: 613294

KEGG: hsa:10055

STRING: 9606.ENSP00000270225

UniGene: Hs.515500

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

The Review of Post-translational Modifications Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Ubiquitin mediated proteolysis Target Therapy

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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