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| Code | CSB-PA061850 |
| Product Type | Polyclonal Antibody |
| Size | US$297 |
| Uniprot No. | P36897 |
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| Protocols | ELISA Protocol Western Blotting(WB) Protocol Immunofluorescence (IF) Protocol |
| Immunogen | Synthesized non-phosphopeptide derived from Human TGF β Receptor I around the phosphorylation site of serine 165 (D-P-S(p)-L-D). |
| Raised in | Rabbit |
| Species Reactivity | Human,Mouse |
| Specificity | The antibody detects endogenous levels of total TGF β Receptor I protein |
| Tested Applications | ELISA,WB,IF;WB:1:500-1:3000,IF:1:100-1:500 |
| Relevance | Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.Franzen P., Cell 75:681-692(1993).Vellucci V.F., Genomics 46:278-283(1997).Lynch M.A., Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases. |
| Form | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality | Polyclonal |
| Alias | ADRB2; ALK-5; Activin receptor-like kinase 5; EC 2.7.11.30; ESK2 |
| Immunogen Species | Homo sapiens (Human) |
| Target Names | TGFBR1 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| References | |
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| Function | Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation. |
| Involvement in disease | Loeys-Dietz syndrome 1 (LDS1); Multiple self-healing squamous epithelioma (MSSE) |
| Subcellular Location | Cell membrane, Single-pass type I membrane protein, Cell junction, tight junction, Cell surface, Membrane raft |
| Protein Families | Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily |
| Tissue Specificity | Found in all tissues examined, most abundant in placenta and least abundant in brain and heart. Expressed in a variety of cancer cell lines (PubMed:25893292). |
| Database Links |
HGNC: 11772 OMIM: 132800 KEGG: hsa:7046 STRING: 9606.ENSP00000364133 UniGene: Hs.494622 |
| Pathway |
Hippo signaling pathway
MAPK signaling pathway TGF-beta signaling pathway Adherens junction Cellular senescence Osteoclast differentiation Th17 cell differentiation AGE-RAGE signaling pathway in diabetic complications Apelin signaling pathway FoxO signaling pathway Endocytosis |
TGFBR1 Antibodies for
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA004276 | TGFBR1 Antibody | Human,Mouse,Rat | WB,IF,ELISA |
| CSB-PA050248 | Phospho-TGFBR1 (S165) Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
TGFBR1 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA699479 | TGFBR1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA206147 | TGFBR1 Antibody | Human,Mouse,Rat | ELISA,IHC |
TGFBR1 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA023451LA01HU | TGFBR1 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA023451LB01HU | TGFBR1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA023451LC01HU | TGFBR1 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA023451LD01HU | TGFBR1 Antibody, Biotin conjugated | Human | ELISA |
TGFBR1 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP023451HU1 CSB-EP023451HU1 CSB-BP023451HU1 CSB-MP023451HU1 |
Recombinant Human TGF-beta receptor type-1(TGFBR1),partial | Yeast E.coli Baculovirus Mammalian cell |
| CSB-CF023451HU | Recombinant Human TGF-beta receptor type-1(TGFBR1) | in vitro E.coli expression system |
TGFBR1 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-EL023451HU | Human TGF-beta receptor type-1(TGFBR1) ELISA kit | serum, plasma, tissue homogenates | 0.039 ng/ml |
2-hydroxyisobutyryl-HIST1H3A (K27) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H3A (K4) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
