Recombinant Human Creatine kinase B-type (CKB)

1. The data revealed a varying but significant increase of CK activity in CKBE individuals as compared to controls, reaching an almost 800-fold increase in two CKBE individuals which also had increased erythrocyte creatine. PMID: 28364583
2. Association and oligomerization of Prx II could take part in recovery and protection of the CK BB enzyme activity from inactivation during heat-induced stress. PMID: 29227081
3. membrane localization of BCK seems to be an important and regulated feature for the fueling of membrane-located, ATP-dependent processes, stressing again the importance of local rather than global ATP concentrations. PMID: 27318991
4. These findings support increased CK activity as protection against ischaemia-reperfusion injury, in particular, protection via CKMT2 in a cardiac-relevant cell line, which merits further investigation in vivo. PMID: 28806770
5. SRC, LYN and CKB expression or DNA methylation could be useful markers for predicting tumor progression. PMID: 26460485
6. CK-MB levels were higher after ERCP in non-ischemic patients compared with a myocardial ischemia group. Creatine phosphokinase levels did not differ significantly between groups. PMID: 25141318
7. CK-B catalytic activity also helps in the formation of protrusive ruffle structures which are actin-dependent and abundant on the surface of both unstimulated and LPS-activated macrophages. PMID: 25538032
8. increased serum Ckbb reflects failure of osteoclasts or suppression of osteoclasts in children with osteogenesis imperfecta during neridronate treatment PMID: 24518563
9. Estimation of CK and its CK isoenzyme fractions can aid in quick and accurate diagnosis of tubal ectopic pregnancy. PMID: 23876027
10. effects of osmolytes on human brain-type creatine kinase folding PMID: 22885020
11. We found that most patients with macular telangiectasia-2 possess retinal autoantibodies, the most prevalent of which were directed against AGL, RBP3, and CK-B. PMID: 23882694
12. analysis of SNPs and their effect on creatine kinase structure and function PMID: 23049898
13. study found promoter SNPs of CKB and TPI1 were weakly associated with schizophrenia;in addition, IFNG polymorphisms were associated with schizophrenia; results suggest that IFNG and proteins affected by IFNG may play a role in the pathogenesis of schizophrenia PMID: 22623148
14. de-methylated CKB gene is inherited that leads to high CKB expression levels in myeloic precursor cells in the bone marrow PMID: 22088263
15. His103 and Phe107 in hASB9-2 are essential for binding to CKB. PMID: 22418839
16. Cigarette smoke induced carbonylation and subsequent degradation of creatine kinase B are involved in the regulation of senescence in bronchial epithelial cells. PMID: 21980054
17. The results suggested that the intra- and inter-subunit domain interactions modified the behavior of kinetic refolding. PMID: 21931810
18. Data demonstrate that the downregulation of CKB may play an important role in colon cancer progression by promoting EMT. PMID: 21308735
19. CKB was up-regulated in women older than 38 years, and its expression in cumulus cells was associated with embryo quality PMID: 20721618
20. These observations suggested that the ability to generate the oxidized form could protect BBCK against the intracellular oxidative stress. PMID: 20923681
21. Report the effects of prior calcium channel blocker therapy on creatine kinase-MB (myocardial form) levels after percutaneous coronary interventions. PMID: 19337554
22. A single troponin I value at 3 days from symptom onset is a better predictor of infarct size compared to peak values and CK-MB. PMID: 20588136
23. Phosphocreatine metabolism in the normal appearing white matter in multiple sclerosis is impaired due to decreased CK-B levels. PMID: 20520825
24. The correlation of CK-BB as a disease biomarker in both CNS and peripheral tissues from Huntington's disease mice and patients may provide a powerful means to assess disease progression and prognosis. PMID: 20460152
25. 2D fingerprinting & mass spectrometry reveal specific targets of protein oxidation in Alzheimer's disease brain, including creatine kinase BB, suggesting involvement of oxidatively modified proteins in neurodegeneration. PMID: 12160938
26. Expression of CKB mRNA and CK-B sometimes occurred in blastic transformation of the hematopoietic system PMID: 15996648
27. CKB was expressed in 78% of colon tumors PMID: 16424007
28. GM130 and BB-CK co-localize specifically in a transient fashion during early prophase of mitosis, when GM130 plays an important role in Golgi fragmentation that starts also at early prophase. PMID: 17036164
29. The asymmetric unit contained two molecules of CKB, giving a crystal volume per protein mass (Vm) of 1.80 A3 Da-1 and a solvent content of 31.6%. PMID: 18309274
30. Autoantibodies to EsteD and BB-CK produced in experimental autoimmune uveoretinitis -induced mice were also detected in some endogenous uveitis patients, suggesting that these proteins might be autoantigens. PMID: 18552983
31. Using a yeast 2-hybrid it was discovered that the C-terminal domain of KCC3, that is lost in most hereditary motor and sensory neuropathy with agenesis of the corpus callosum-causing mutations, directly interacts with brain-specific creatine kinase. PMID: 18566107
32. The Tat-CK fusion protein markedly increased endogenous CK activity levels within PC12 cells. PMID: 18682038
33. Three structural aspects of human-brain-type-creatine-kinase were identified by X-ray crystallography: the ligand-free-form at 2.2A; the ADP-Mg2+, nitrate, and creatine complex (transition-state-analogue complex; TSAC); and the ADP-Mg2+-complex at 2.0A. PMID: 18977227
34. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. PMID: 19165527

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HGNC: 1991

OMIM: 123280

KEGG: hsa:1152

STRING: 9606.ENSP00000299198

UniGene: Hs.173724